In silico anti-Alzheimer potential of bioactive compounds in fungi from the African Natural Products Database

Authors

  • Cicilien Quentin Nongni Piebeng Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon
  • Bruno Dupon Ambamba Akamba Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon
  • Fils Armand Ella Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon
  • Agwe Nicoline Injoh Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon
  • Dany Joël Ngassa Ngoumen Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon
  • Damaris Enyegue Mandob Department of Biological Sciences, Higher Teacher’s Training College, University of Yaounde 1
  • Judith Laure Ngondi Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Abstract

Download and view PDF for abstract

Keywords:

fungi compounds, ANPDB, in silico, AD, BBB

DOI

https://doi.org/10.22270/jddt.v14i1.6250

Author Biographies

Cicilien Quentin Nongni Piebeng, Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

Bruno Dupon Ambamba Akamba, Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

Fils Armand Ella, Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

Department of Pharmacology, Faculty of Health Sciences, School of Clinical Medicines, University of Fee State, P.O.Box 339 Bloemfontein 9300, South Africa

Agwe Nicoline Injoh, Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Dany Joël Ngassa Ngoumen, Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

Department of Pharmacology, Faculty of Health Sciences, School of Clinical Medicines, University of Fee State, P.O.Box 339 Bloemfontein 9300, South Africa

Damaris Enyegue Mandob, Department of Biological Sciences, Higher Teacher’s Training College, University of Yaounde 1

Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

Judith Laure Ngondi, Department of Biochemistry, Faculty of Science, the University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

Center of Nutrition and Functional Foods, P.O. box 8024 Yaounde, Cameroon

References

Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021;22(2):634. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826851/ https://doi.org/10.3390/ijms22020634 PMid:33435246 PMCid:PMC7826851

Bains A, Chawla P, Kaur S, Najda A, Fogarasi M, Fogarasi S. Bioactives from Mushroom: Health Attributes and Food Industry Applications. Materials (Basel). 2021 Dec 11;14(24):7640. https://doi.org/10.3390/ma14247640 PMid:34947237 PMCid:PMC8706457

Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. https://doi.org/10.3390/molecules28145393 PMid:37513265 PMCid:PMC10384337

Dasgupta A, Acharya K. Mushrooms: an emerging resource for therapeutic terpenoids. 3 Biotech. 2019 Oct;9(10):369. https://doi.org/10.1007/s13205-019-1906-2 PMid:31588393 PMCid:PMC6760460

Bhambri A, Srivastava M, Mahale VG, Mahale S, Karn SK. Mushrooms as Potential Sources of Active Metabolites and Medicines. Front Microbiol; 13:837266. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090473/ https://doi.org/10.3389/fmicb.2022.837266 PMid:35558110 PMCid:PMC9090473

Silva AM, Preto M, Grosso C, Vieira M, Delerue-Matos C, Vasconcelos V, et al. Tracing the Path between Mushrooms and Alzheimer's Disease-A Literature Review. Molecules. 2023;28(14):5614. Available from: https://www.mdpi.com/1420-3049/28/14/5614 https://doi.org/10.3390/molecules28145614 PMid:37513486 PMCid:PMC10384108

Peng Y, Jin H, Xue YH, Chen Q, Yao SY, Du MQ, et al. Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks. Front Aging Neurosci. 2023;15:1206572. https://doi.org/10.3389/fnagi.2023.1206572 PMid:37600514 PMCid:PMC10438465

Cummings J, Zhou Y, Lee G, Zhong K, Fonseca J, Cheng F. Alzheimer's disease drug development pipeline: 2023. Alzheimers Dement (N Y). 2023;9(2):e12385. https://doi.org/10.1002/trc2.12385 PMid:37251912 PMCid:PMC10210334

Rai SN, Mishra D, Singh P, Vamanu E, Singh MP. Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases. Biomed Pharmacother. 2021 May;137:111377. https://doi.org/10.1016/j.biopha.2021.111377 PMid:33601145

Cheong SL, Tiew JK, Fong YH, Leong HW, Chan YM, Chan ZL, et al. Current Pharmacotherapy and Multi-Target Approaches for Alzheimer's Disease. Pharmaceuticals. 2022;15(12):1560. Available from: https://www.mdpi.com/1424-8247/15/12/1560 https://doi.org/10.3390/ph15121560 PMid:36559010 PMCid:PMC9781592

Ntie-Kang F, Telukunta KK, Döring K, Simoben CV, A. Moumbock AF, Malange YI, et al. NANPDB: A Resource for Natural Products from Northern African Sources. J Nat Prod. 2017;80(7):2067-76. https://doi.org/10.1021/acs.jnatprod.7b00283 PMid:28641017

Simoben CV, Qaseem A, Moumbock AFA, Telukunta KK, Günther S, Sippl W, et al. Pharmacoinformatic Investigation of Medicinal Plants from East Africa. Molecular Informatics. 2020;39(11):2000163. https://doi.org/10.1002/minf.202000163 PMid:32964659 PMCid:PMC7685152

Kuppusamy A, Arumugam M, George S. Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer's disease. Int J Biol Macromol. 2017 Feb;95:199-203. https://doi.org/10.1016/j.ijbiomac.2016.11.062 PMid:27871793

Akamba BDA, Pieben CQN, Kenassi MBN, Ebouel FLE, Nanhah JVK, Ella FA, et al. In silico pharmacological study of lacourtianal, a new terpenoid isolated from the stem bark of Chrysophyllum lacourtianum De Wild (Sapotaceae) against Alzheimer's disease. Journal of Drug Delivery and Therapeutics. 2023;13(12):84-90. https://doi.org/10.22270/jddt.v13i12.6322

Konc J, Konc JT, Penca M, Janežič D. Binding-sites Prediction Assisting Protein-protein Docking. Acta Chim Slov. 2011 Sep;58(3):396-401.

Goodsell DS, Morris GM, Olson AJ. Automated docking of flexible ligands: Applications of AutoDock. Journal of molecular recognition : JMR. 1996;9(1):1-5. Available from: https://www.researchwithnj.com/en/publications/automated-docking-of-flexible-ligands-applications-of-autodock https://doi.org/10.1002/(SICI)1099-1352(199601)9:1<1::AID-JMR241>3.0.CO;2-6

Skaria AP. The economic and societal burden of Alzheimer disease: managed care considerations. Am J Manag Care. 2022 Sep;28(10 Suppl):S188-96. https://doi.org/10.37765/ajmc.2022.89236 PMid:36197132

Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and Drugability. Adv Drug Deliv Rev. 2016;101:89-98. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910824/ https://doi.org/10.1016/j.addr.2016.05.007 PMid:27182629 PMCid:PMC4910824

Obaid RJ, Naeem N, Mughal EU, Al-Rooqi MM, Sadiq A, Jassas RS, et al. Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase. RSC Adv. 2022;12(31):19764-855. Available from: https://pubs.rsc.org/en/content/articlelanding/2022/ra/d2ra03081k https://doi.org/10.1039/D2RA03081K PMid:35919585 PMCid:PMC9275557

Li S, Li AJ, Travers J, Xu T, Sakamuru S, Klumpp-Thomas C, et al. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS DISCOVERY: Advancing the Science of Drug Discovery. 2021;26(10):1355-64. https://doi.org/10.1177/24725552211030897 PMid:34269114 PMCid:PMC8637366

Huang LK, Kuan YC, Lin HW, Hu CJ. Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update. Journal of Biomedical Science [Internet]. 2023 Oct 2 [cited 2023 Nov 30];30(1):83. https://doi.org/10.1186/s12929-023-00976-6 PMid:37784171 PMCid:PMC10544555

Spronk SA, Carlson HA. The Role of Tyrosine 71 in Modulating the Flap Conformations of BACE1. Proteins. 2011;79(7):2247-59. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577374/ https://doi.org/10.1002/prot.23050 PMid:21590744 PMCid:PMC3577374

Chauhan N, Paliwal S, Jain S, Verma K, Paliwal S, Sharma S. GSK-3β and its Inhibitors in Alzheimer's Disease: A Recent Update. Mini Rev Med Chem. 2022;22(22):2881-95. https://doi.org/10.2174/1389557522666220420094317 PMid:35450523

Hashweh NN, Bartochowski Z, Khoury R, Grossberg GT. An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease. Expert Opinion on Pharmacotherapy. 2020; 21(6):619-27. https://doi.org/10.1080/14656566.2020.1719066 PMid:32037892

Published

15-01-2024
Statistics
Abstract Display: 285
PDF Downloads: 209
PDF Downloads: 159

How to Cite

1.
Piebeng CQN, Ambamba Akamba BD, Ella FA, Injoh AN, Ngoumen DJN, Mandob DE, et al. In silico anti-Alzheimer potential of bioactive compounds in fungi from the African Natural Products Database. J. Drug Delivery Ther. [Internet]. 2024 Jan. 15 [cited 2024 Dec. 6];14(1):103-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6250

Issue

Vol. 14 No. 1 (2024): Volume 14, Issue 1, Jan 2024

Section

Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Piebeng CQN, Ambamba Akamba BD, Ella FA, Injoh AN, Ngoumen DJN, Mandob DE, et al. In silico anti-Alzheimer potential of bioactive compounds in fungi from the African Natural Products Database. J. Drug Delivery Ther. [Internet]. 2024 Jan. 15 [cited 2024 Dec. 6];14(1):103-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6250
Crossref
Scopus
Google Scholar
Europe PMC