Qualitative Phytochemical Investigation and Acute Oral Toxicity Study on Ethanolic Extract of Curcuma longa Leaves

Authors

  • Pratima Chourasiya PG Student, Swami Vivekanand College of Pharmacy, Indore (M. P.), India
  • Rekha Gour Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India
  • Anant K. Patel Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

Abstract

The study focused on evaluating the acute toxicity and phytochemical composition of Curcuma longa leaves using Swiss albino mice. The investigation involved a two-phase acute toxicity test, with doses up to 5000 mg/kg administered orally. The results indicated no toxicity at lower doses, while signs of weakness, salivation, and reduced movement were observed at 1600 mg/kg. Lethal effects were noted at 5000 mg/kg, establishing the LD50 at 2154.06 mg/kg. Phytochemical analysis revealed the presence of alkaloids, flavonoids, glycosides, tannins, and volatile oils in the ethanolic extract. The extract exhibited a 27.37% yield, characterized by a yellowish-orange color and a sticky consistency. This comprehensive investigation sheds light on both the acute toxicity profile and the diverse phytochemical components presents in Curcuma longa leaves.

Keywords: Curcuma longa, Phytoconstituent, Acute oral toxicity, Lokes method.

Keywords:

Curcuma longa, Phytoconstituent, Acute oral toxicity, Lokes method

DOI

https://doi.org/10.22270/jddt.v14i1.6244

Author Biographies

Pratima Chourasiya, PG Student, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

PG Student, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

Rekha Gour, Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

Anant K. Patel, Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

Professor, Swami Vivekanand College of Pharmacy, Indore (M. P.), India

References

Vijaya Chavan Lobo, Acute toxicity studies of Some Indian Medicinal plants, Journal of Pharmacognosy and Phytochemistry, 2010; 2. https://doi.org/10.1016/S0975-3575(10)80094-X

Heath DD, Khwaja F, Rock CL. Curcumin content of turmeric and curry powders. FASEB J. 2004; 18:A 125.

Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal, 1997; 15:1867-76. https://doi.org/10.1016/S0731-7085(96)02024-9

PMid:9278892

Gostry Aldica Dohude, Inhibitory test of turmeric leaves extract (Curcuma Longa. L) against the growth of Streptococcus mutans bacterial growth in vitro, Journal of Syiah Kuala Dentistry Society, 2022; 7(2):73-77. https://doi.org/10.24815/jds.v7i2.30229

C.K. Kokate, A.P. Purohit, S.B. Gokhale. Pharmacognosy. Nirali Prakashan, 53rd edition, 2017; 7.1-7.46.

Dr. K.R. Khandelwal, Dr. Vrunda Sethi. Practical pharmacognosy techniques and experiments. Nirali Prakashan, 24th edition, 2014, 23.13-23.15, 25.1-25.9.

Erhirhie Earnest Oghenesuvwe, Ekene, Nwoke E. and Ajaghaku Daniel Lotanna, Guidelines on dosage calculation and stock solution preparation in experimental animals’ studies, 2014, 4(18):100-106.

Zakari Abdu, Acute Toxicity (LD50) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC50 and LC90) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC, Natural Products Chemistry & Research, 2016; 4(6). https://doi.org/10.4172/2329-6836.1000240

Published

15-01-2024
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How to Cite

1.
Chourasiya P, Gour R, Patel AK. Qualitative Phytochemical Investigation and Acute Oral Toxicity Study on Ethanolic Extract of Curcuma longa Leaves. J. Drug Delivery Ther. [Internet]. 2024 Jan. 15 [cited 2025 Feb. 12];14(1):73-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6244

How to Cite

1.
Chourasiya P, Gour R, Patel AK. Qualitative Phytochemical Investigation and Acute Oral Toxicity Study on Ethanolic Extract of Curcuma longa Leaves. J. Drug Delivery Ther. [Internet]. 2024 Jan. 15 [cited 2025 Feb. 12];14(1):73-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6244