Nanotechnology and Nanocapsule-Based Approaches for the Diagnosis and Therapeutics of Diabetes Mellitus: A Concise Survey
Abstract
A serious health concern of frightening proportions is diabetes mellitus, a common metabolic illness marked by increased blood sugar levels as a result of insufficient insulin production or response. Nanosensors and nanomaterials have recently shown tremendous promise for enhancing glucose detection for the treatment of diabetes. Significant improvements in glucose sensor sensitivity, specificity, and reversibility have been achieved through the incorporation of nanoscale carbon structures, nanocomposites, and other nanomaterials. The use of these tailored nanocarriers offers a viable technique to enhance patient compliance and diabetes management by addressing the difficulties associated with oral peptide medication delivery for the treatment of diabetes caused by adverse circumstances in the gastrointestinal system. Nanocapsules are a promising approach for effective medication transportation via biological barriers by protecting drug molecules from the biological environment. A workable solution to problems with oral peptide medicine distribution for treating diabetes, particularly when it comes to unfavorable gastrointestinal conditions, is the use of customized nanocarriers. These nanocarriers have a flexible design and special in vivo characteristics that make it possible to go beyond cellular and tissue absorption barriers while improving the stability and effectiveness of therapeutic peptides. The management of diabetes mellitus has a great deal of potential for targeted lipid-based nanoparticles, which operate as an efficient drug delivery technique for oral administration of therapeutic peptides. With these developments in nanotechnology and nanocapsule-based techniques, diabetes treatment might be improved, patient compliance could be increased, and drug administration frequency could be decreased, potentially changing the field. This article presents a comprehensive review of recent advances in nanotechnology for diabetes mellitus diagnosis and the utilization of nanocapsules in diabetes treatment
Keywords: Nanotechnology, Nanocapsules, Diabetes Mellitus, Nanocarriers, Nanomaterial, Nanotube
Keywords:
Nanotechnology, Nanocapsules, Diabetes Mellitus, Nanocarriers, Nanomaterial, Nanotube
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References
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33. Yue C, Yunru Y, Yuntian Z, Gang Z,* and Yuanjin Z*, Cold-Responsive Nanocapsules Enable the Sole-Cryoprotectant-Trehalose Cryopreservation of β Cell-Laden Hydrogels for Diabetes Treatment, Small. 2019 Dec; 15(50):e1906289. https://doi.org/10.1002/smll.201906289
34. Yining X, Dario C, Mireille A, Giulio G. M, Patrice D. Cani, Véronique P, and Ana P, Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells, Mol Pharm. 2018 Jan 2;15(1):108-115. https://doi.org/10.1021/acs.molpharmaceut.7b00742
35. Shamekhi F, Tamjid E, Khajeh K. Development of chitosan coated calcium-alginate nanocapsules for oral delivery of liraglutide to diabetic patients. Biomac. 2018. https://doi.org/10.1016/j.ijbiomac.2018.08.078
36. Dı'az A, David A, Pe' rez R, Gonza' lez ML, Ba'az A, Wark SE, Zhang P, Clearfield A, Colo'n JL. Nanoencapsulation of Insulin into Zirconium Phosphate for Oral Delivery Applications. Biomacromolecules. 2010. https://doi.org/10.1021/bm100659p
37. Kumara S, Bhanjanaa G, Vermaa RK, Dhingrab D, Dilbaghia N, Kimc KH. Metformin-loaded alginate nanoparticles as an effective antidiabetic agent for controlled drug release. Journal of Pharmacy and Pharmacology. 2016. https://doi.org/10.1111/jphp.12672
38. Thwala LN, Delgado DP, Leone K, Marigo I, Bennetti F, Chenlo M, Alvarez CV, Tovar S, Dieguez C, Csaba NS, Alonso MJ. Protamine nanocapsules as carriers for oral peptide delivery. Corel. 2018. https://doi.org/10.1016/j.jconrel.2018.10.022
39. Agazzi M, Herrera S, Cortez ML, Marmisollé W, Tagliazucchi M, Azzaroni O. Insulin-Delivery from Glucose-Responsive Self-Assembled Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy. Chem. Eur. J. 10.1002/chem.201905075.
40. Xu Y, Keersmaecker HD, Braeckmans K, Smedt SD, Cani PD, Préat Vé, Beloqui A. Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment. Biomaterils. 2020. https://doi.org/10.1016/j.biomaterials.2020.120209
2. Khan RMM, Chua ZJY, Tan JC, Yang Y, Zhao ZL. Pre-diabetes to diabetes: Diagnosis, treatment and translational research. Medicina. 2019; 55:546. https://doi.org/10.3390/medicina55090546
3. American Diabetes Association. Diagnosis and classification of Diabetes mellitus. Diabetes Care. 2014 Jan; 37 Suppl 1:581-90. https://doi.org/10.2337/dc14-S081
4. DeFronzo R, Ferrannini E, Groop L, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015; 1:15019. https://doi.org/10.1038/nrdp.2015.19
5. Donald RC. Gestational diabetes mellitus. Clin Chem. 2013 Sep; 59(9):1310. https://doi.org/10.1373/clinchem.2013.203331
6. Chiefari E, Arcidiacono B, Foti D, et al. Gestational diabetes mellitus: an updated overview. J Endocrinol Invest. 2017; 40:899-909. https://doi.org/10.1007/s40618-016-0607-5
7. Kohei K. Pathophysiology of Type 2 diabetes and Its treatment policy. JMAJ. 2010; 53(1):41-46.
8. Nathaniel GC, Kathleen MF, SHIELD Study Group. Symptoms of Diabetes and their association with risk and presence of diabetes. Diabetes Care. 2007 Nov; 30(11):2868-73. https://doi.org/10.2337/dc07-0816
9. Tiwari P. Recent Trends in Therapeutic Approaches for Diabetes Management. A comprehensive Update. J Diabetes Res. 2015; 2015:340838. https://doi.org/10.1155/2015/340838
10. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov; 157:107843. https://doi.org/10.1016/j.diabres.2019.107843
11. Kothamasu P, Kanumur H, Ravur N, Maddu C, Parasuramrajam R, Thangavel S. Nanocapsules: the weapons for novel drug delivery systems. Bio Impacts. 2010; 2(12):71-81.
12. Nilewar G, Mute P. B, Talhan P. P, Thakre S. NANOCAPSULES: NANO NOVEL DRUG DELIVERY SYSTEM. Pharma Tutor. 2014; 5(6).
13. Kamble P, Rathod M, Mule J, Deshpande R. Nano capsules: Nano Novel Drug Delivery System. International Journal of Innovative Research in Technology. 2020; 6(12):2349-6002.
14. Pisal M, Barbade P, Dudhal S. Nanocapsule. International Jr Pharmacy Science Review and Research. 2020; 60(12): article no. 10.
15. Radhika P. R, Sasikanth, Sivakumar T. NANOCAPSULES: A NEW APPROACH IN DRUG DELIVERY. IJPSR. 2011; 2.
16. Bratlie KM, York RL, Invernale MA, Langer R, Anderson DG. Materials for diabetes therapeutics. Advanced Healthcare Materials. 2012; 1:267-284. https://doi.org/10.1002/adhm.201200037
17. Pickup JC, Zhi Z-L, Khan F, Saxl T, Birch DJS. Nanomedicine and its potential in diabetes research and practice. Diabetes/Metabolism Research and Reviews. 2008; 24:604-610. https://doi.org/10.1002/dmrr.893
18. Bahshi L, Freeman R, Gill R, Willner I. Optical Detection of Glucose by Means of Metal Nanoparticles or Semiconductor Quantum Dots. Small. 2009; 5:676-680. https://doi.org/10.1002/smll.200801403
19. Veetil JV, Jin S, Ye K. A glucose sensor protein for continuous glucose monitoring. Biosensors and Bioelectronics. 2010; 26:1650-1655. https://doi.org/10.1016/j.bios.2010.08.052
20. Gordijo CR, Shuhendler AJ, Wu XY. Glucose-Responsive Bioinorganic Nanohybrid Membrane for Self-Regulated Insulin Release. Advanced Functional Materials. 2010; 20:1404-1412. https://doi.org/10.1002/adfm.200901581
21. Yetisen, AK.; Montelongo, Y.; da Cruz Vasconcellos, F.; Martinez-Hurtado, JL.; Neupane, S.; Butt, H.; Qasim, MM.; Blyth, J.; Burling, K.; Carmody, JB., et al. Reusable, Robust, and Accurate Laser-Generated Photonic Nanosensor. Nano Letters. 2014. https://doi.org/10.1021/nl5012504
22. Chun AL. Nanosensors: Bring it on. Nature Nanotechnology. 2006:84. https://doi.org/10.1038/nnano.2006.84
23. Ravaine V, Ancla C, Catargi B. Chemically controlled closed-loop insulin delivery. Journal of Controlled Release. 2008; 132:2-11. https://doi.org/10.1016/j.jconrel.2008.08.009
24. Chertok B, Webber MJ, Succi MD, Langer R. Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies. Molecular Pharmaceutics. 2013; 10:3531-3543. https://doi.org/10.1021/mp4003283
25. Veetil JV, Jin S, Ye K. Fluorescence lifetime imaging microscopy of intracellular glucose dynamics. Journal of Diabetes Science and Technology. 2012; 6:1276-1285. https://doi.org/10.1177/193229681200600606
26. Uehara H, Kakiage M, Sekiya M, Sakuma D, Yamonobe T, Takano N, Barraud A, Meurville E, Ryser P. Size-Selective Diffusion in Nanoporous but Flexible Membranes for Glucose Sensors. ACS Nano. 2009; 3:924-932. https://doi.org/10.1021/nn8008728
27. Shan C, Yang H, Han D, Zhang Q, Ivaska A, Niu L. Graphene/AuNPs/chitosan nanocomposites film for glucose biosensing. Biosensors and Bioelectronics. 2010; 25:1070-1074. https://doi.org/10.1016/j.bios.2009.09.024
28. Zeng X, Li X, Xing L, Liu X, Luo S, Wei W, Kong B, Li Y. Electrodeposition of chitosan-ionic liquid-glucose oxidase biocomposite onto nano-gold electrode for amperometric glucose sensing. Biosensors and Bioelectronics. 2009; 24:2898-2903. https://doi.org/10.1016/j.bios.2009.02.027
29. Wu Q, Wang L, Yu H, Wang J, Chen Z. Organization of glucose-responsive systems and their properties. Chemical reviews. 2011; 111:7855-7875. https://doi.org/10.1021/cr200027j
30. Sandhu A. Glucose sensing: Silicon's sweet spot. Nature Nanotechnology. 2007. https://doi.org/10.1038/nnano.2007.2
31. Wang G, Mantey K, Nayfeh MH, Yau S-T. Enhanced amperometric detection of glucose using Si29 particles. Applied Physics Letters. 2006; 89. https://doi.org/10.1063/1.2405384
32. Dong X-C, Xu H, Wang X-W, Huang Y-X, Chan-Park MB, Zhang H, Wang L-H, Huang W, Chen P. 3D Graphene-Cobalt Oxide Electrode for High-Performance Supercapacitor and Enzymeless Glucose Detection. ACS Nano. 2012; 6:3206-3213. https://doi.org/10.1021/nn300097q
33. Yue C, Yunru Y, Yuntian Z, Gang Z,* and Yuanjin Z*, Cold-Responsive Nanocapsules Enable the Sole-Cryoprotectant-Trehalose Cryopreservation of β Cell-Laden Hydrogels for Diabetes Treatment, Small. 2019 Dec; 15(50):e1906289. https://doi.org/10.1002/smll.201906289
34. Yining X, Dario C, Mireille A, Giulio G. M, Patrice D. Cani, Véronique P, and Ana P, Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells, Mol Pharm. 2018 Jan 2;15(1):108-115. https://doi.org/10.1021/acs.molpharmaceut.7b00742
35. Shamekhi F, Tamjid E, Khajeh K. Development of chitosan coated calcium-alginate nanocapsules for oral delivery of liraglutide to diabetic patients. Biomac. 2018. https://doi.org/10.1016/j.ijbiomac.2018.08.078
36. Dı'az A, David A, Pe' rez R, Gonza' lez ML, Ba'az A, Wark SE, Zhang P, Clearfield A, Colo'n JL. Nanoencapsulation of Insulin into Zirconium Phosphate for Oral Delivery Applications. Biomacromolecules. 2010. https://doi.org/10.1021/bm100659p
37. Kumara S, Bhanjanaa G, Vermaa RK, Dhingrab D, Dilbaghia N, Kimc KH. Metformin-loaded alginate nanoparticles as an effective antidiabetic agent for controlled drug release. Journal of Pharmacy and Pharmacology. 2016. https://doi.org/10.1111/jphp.12672
38. Thwala LN, Delgado DP, Leone K, Marigo I, Bennetti F, Chenlo M, Alvarez CV, Tovar S, Dieguez C, Csaba NS, Alonso MJ. Protamine nanocapsules as carriers for oral peptide delivery. Corel. 2018. https://doi.org/10.1016/j.jconrel.2018.10.022
39. Agazzi M, Herrera S, Cortez ML, Marmisollé W, Tagliazucchi M, Azzaroni O. Insulin-Delivery from Glucose-Responsive Self-Assembled Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy. Chem. Eur. J. 10.1002/chem.201905075.
40. Xu Y, Keersmaecker HD, Braeckmans K, Smedt SD, Cani PD, Préat Vé, Beloqui A. Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment. Biomaterils. 2020. https://doi.org/10.1016/j.biomaterials.2020.120209
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Terse P, Pawaskar P, Pawar PK, Samant SS, Teli A. Nanotechnology and Nanocapsule-Based Approaches for the Diagnosis and Therapeutics of Diabetes Mellitus: A Concise Survey. JDDT [Internet]. 15Sep.2023 [cited 2Oct.2023];13(9):151-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6197
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