Therapeutic measures for COVID-19 and their clinical relevance of hERG channel translocation: A Pharmacodynamic approach

Authors

  • Trilochan Satapathy Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, Chhattisgarh, India https://orcid.org/0000-0001-6871-1288
  • Kunal Chandrakar University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India
  • Abinash Satapathy College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India
  • Neha Yadav College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India
  • Shivangee Singh University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India
  • Dheeraj Kumar University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

Abstract

The COVID-19 caused by SARS-CoV-2 poses a massive challenge to the medical system, especially the safe and effective COVID-19 treatment methods, forcing people to look for drugs that may have therapeutic effects as soon as possible. Some old drugs have shown clinical benefits after a few small clinical trials attracting significant attention. Clinically, however, many medications, including those currently shown to be effective against COVID-19, such as Chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir, may cause cardiotoxicity by acting on cardiac potassium channel, hERG channel due to their off-target effect. Blocking of hERG prolongs QT intervals on the electrocardiogram and thus might induce severe ventricular arrhythmias and even sudden cardiac death. Therefore, while focusing on the efficacy of COVID-19 drugs, the fact that they block hERG from causing arrhythmias cannot be ignored. To develop safe and effective drugs, it is necessary to understand the interactions between drugs and hERG channels and the molecular mechanism behind this high affinity. In this review, we focus on the biochemical and molecular mechanistic aspects of related drug blockade in the hERG, trying to provide insights into the QT interval prolongation caused by potential therapeutic drugs for COVID-19 and hope to weigh the risks and benefits when using related drugs.

Keywords: COVID-19; Therapeutic measures; hERG channel; Pharmacodynamic; Vaccines

Keywords:

COVID-19, Therapeutic measures, hERG channel, Pharmacodynamic, Vaccines

DOI

https://doi.org/10.22270/jddt.v13i11.6007

Author Biographies

Trilochan Satapathy, Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, Chhattisgarh, India

Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, Chhattisgarh, India

Kunal Chandrakar, University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

University College of  Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

Abinash Satapathy, College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India

College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India

Neha Yadav, College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India

College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, Chhattisgarh, India

Shivangee Singh, University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

University College of  Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

Dheeraj Kumar, University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

University College of  Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

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15-11-2023
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How to Cite

1.
Satapathy T, Chandrakar K, Satapathy A, Yadav N, Singh S, Kumar D. Therapeutic measures for COVID-19 and their clinical relevance of hERG channel translocation: A Pharmacodynamic approach. J. Drug Delivery Ther. [Internet]. 2023 Nov. 15 [cited 2025 Feb. 13];13(11):165-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6007

How to Cite

1.
Satapathy T, Chandrakar K, Satapathy A, Yadav N, Singh S, Kumar D. Therapeutic measures for COVID-19 and their clinical relevance of hERG channel translocation: A Pharmacodynamic approach. J. Drug Delivery Ther. [Internet]. 2023 Nov. 15 [cited 2025 Feb. 13];13(11):165-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6007

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