Habb-e-Azaraqi, A Potent Unani Pharmacopoeial preparation used in Neurological disorder: A review
Unani medicine relies on drugs of natural origin for the treatment of various medical conditions. It is practised throughout Asia and particularly in India. The rich natural drug asset of Unani medicine includes both single and compound drugs. Habb-e-Azaraqi is a polyherbal Unani formulation used clinically since decades for the management of various neurological disorders like facial palsy, paralysis, gout and arthritis. The explicit nature of Habb-e-Azaraqi rationalizes its use in nervine disorders. The main ingredient of Habb-e-Azaraqi is Azaraqi mudabbar (detoxified Strychnos nux-vomica L.) which is known for its diverse medicinal uses. This review highlights the traditional uses of Habb-e-Azaraqi, phytochemistry and pharmacological properties of its ingredient.
Keyword: Habb-e-Azaraqi; Facial palsy; Paralysis; Strychnos nux-vomica; Unani medicine
2. Aleem M, Imran Khan M, Islam Usmani Q, Ahmad A. Review on Darunaj-aqrabi (Doronicum hookeri C.B. Clarke): an Unexplored Medicinal Plant of Unani System of Medicine. J AYUSH Ayurveda, Yoga, Unani, Siddha Homeopath [Internet]. 2020 Aug 2; 9(2):41-52. Available from: http://medicaljournals.stmjournals.in/index.php/JoAYUSH/article/view/2108 https://doi.org/10.37591/joayush.v9i2.2108
3. Rahman S, Jahan N, Makbul SAA, Ahmad M, Gani MA. Scientific appraisal of Unani concept of islah-e-advia (rectification/purification of drugs) and its importance. J Ethnopharmacol [Internet]. 2020 Aug https://doi.org/10.1016/j.jep.2020.112880
258(October 2019):112-880. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874119341170
4. Suhail S, Jamil SS, Jilani S, Jahangir U, Qamar MW. Habb-e-Suranjaan: A classical analgesic Unani formulation. Int J Adv Pharm Med Bioallied Sci. 2017; 2017:1-6.
5. Akhtar O, Rani S, Shamsi S. Need of Standardization of Habb: A Unani Medicine. J AYUSH Ayurveda, Yoga, Unani, Siddha Homeopath [Internet]. 2017 [cited 2021 Jan 10]; 6(2):37-44. Available from: www.stmjournals.com
6. Khan A. Qarabadeen E Azam (Urdu translation). New Delhi (India): Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Govt. of India; 1996.
7. Kabiruddin M. Bayaz-e-Kabeer, Part II. New Delhi: Idara Kitabu-us-Shifa; 2010.
8. Anonymous. Qarabadeen Majeedi. 9th ed. New Delhi (India): (Waqf Hamdard) All India Unani Tibbi Confrence; 1986.
9. Anonymous. National Formulary of Unani Medicine part 1. first. New Delhi (India): Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Govt. of India; 2006. 1-337 p.
10. Kabiruddin M. Al-Qarabadeen. New Delhi: CCRUM, Department of AYUSH. Ministry of Health and Family Welfare, Government of India; 2006.
11. Khan MS. Bayaz E Khas (Urdu Translation). New Delhi (India): Ejaz publishing house; 2006.
12. Anonymous. Physicochemical Standards of Unani Formulation, Part 2. New Delhi (India): Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Govt. of India; 1987.
13. Behera MC, Mohanty TL, Paramanik BK. Silvics , phytochemistry and ethnopharmacy of endangered poison nut tree ( Strychnos nux - vomica L . ) : A review. J Pharmacogn Phytochem. 2017; 6(5):1207-16.
14. Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M, Khan MA. Biological role of Piper nigrum L. (Black pepper): A review. Asian Pac J Trop Biomed. 2012; 2(3 SUPPL.):1-10. https://doi.org/10.1016/S2221-1691(12)60524-3
15. Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol [Internet]. 2020 Jan; 247:112255. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874119326443 https://doi.org/10.1016/j.jep.2019.112255
16. Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, et al. Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway. Toxicol Lett. 2013; https://doi.org/10.1016/j.toxlet.2013.07.024
17. Khan M, Siddiqui M. Antimicrobial activity of piper fruits. Indian J Nat Prod Resour. 2007;
18. AO C, AAP C, ATRD A, JRG D, KBF S, PIM C, et al. Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the Parkinson's disease model in rats. J Neurol Ther [Internet]. 2015 Nov 2; 1(1):1-8. Available from: http://nobleresearch.org/Doi/10.14312/2397-1304.2015-1 https://doi.org/10.14312/2397-1304.2015-1
19. Chaudhary SK, Mukherjee PK, Maiti N, De Kumar A, Bhadra S, Saha BP. Evaluation of angiotensin converting enzyme inhibition and anti-oxidant activity of Piper longum L. Indian J Tradit Knowl. 2013; 12(3):478-82.
20. Juvekar M, Kulkarni M, Juvekar A. Anti-stress, nootropic and anticonvulsant potential of fruit extracts of Piper longum L. Planta Med. 2008; 74(09). https://doi.org/10.1055/s-0028-1084242
21. Yaqub S, Aftab M, Asif M, Yousuf PY. QUALITY ASSESSMENT OF UNANI POLYHERBAL FORMULATION "HABB-E-AZARAQI" BY CONTEMPORARY SCIENTIFIC PARAMETERS. Int J Pharm Sci Res. 2013; 4(9):3569-74.
22. Khan A. Muheet-i Azam, Vol 1. New Delhi (India): Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Govt. of India; 2011.
23. Ghani M. Khazainul Advia (Urdu). New Delhi (India): Idara Kitab al Shifa; 2011.
24. Kabeeruddin M. Makhzanul Mufradat. New Delhi: Aijaz Publication; 2014. 392 p.
25. Khan A. Muheet-e-Azam, Vol 3. New Delhi (India): Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Govt. of India; 2014.
26. Haleem A. Mufradat Azizi. New Delhi (India): Central Council for Research in Unani Medicine (CCRUM); 2009.
27. Patel K, Laloo D, Singh GK, Gadewar M, Patel DK. A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report. Chin J Integr Med. 2017; (221005):1-13. https://doi.org/10.1007/s11655-016-2514-1
28. Prakash O, Kumar A, Kumar P, Ajeet A. Anticancer Potential of Plants and Natural Products: A Review. Am J Pharmacol Sci. 2013; https://doi.org/10.12691/ajps-1-6-1
29. Abirami A, Sinsinwar S, Rajalakshmi P, Brindha P, Rajesh YBRD, Vadivel V. Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model. Drug Chem Toxicol [Internet]. 2019 Oct 23; 1-11. Available from: https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1681445 https://doi.org/10.1080/01480545.2019.1681445
30. Parida N. K., Sahu M. R., Debata P.C., Panda PK. Analgesic and anticonvulsant effects of extracts from the leaves of strychnos nux vomica Linn. | | Virtual Health Sciences Library. Hamdard Med [Internet]. 2011 [cited 2021 Jan 10];54(3):9-18. Available from: https://vlibrary.emro.who.int/imemr/analgesic-and-anticonvulsant-effects-of-extracts-from-the-leaves-of-strychnos-nux-vomica-linn-2/
31. Duddukuri GR, Brahmam AN, Rao DN. Suppressive effect of strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice. Indian J Biochem Biophys. 2008;
32. Shoba FG, Thomas M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol. 2001; https://doi.org/10.1016/S0378-8741(00)00379-2
33. Eldahshan OA, Abdel-Daim MM. Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica. Cytotechnology. 2015; https://doi.org/10.1007/s10616-014-9723-2
34. Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. J Ethnopharmacol [Internet]. 2006 Apr; 105(1-2):154-60. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874105007440 https://doi.org/10.1016/j.jep.2005.10.028
35. Chitra V, Varma P VKRCH, Raju MVRK, Prakash KJ. Study of antidiabetic and free radical scavenging activity of the seed extract of Strychnos nuxvomica. Int J Pharm Pharm Sci. 2010;
36. Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Crit Rev Food Sci Nutr. 2019; 59:S210-43. https://doi.org/10.1080/10408398.2019.1565489
37. Damanhouri ZA. A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices. Med Aromat Plants. 2014; 03(03).
38. Ahmad N, Fazal H, Abbasi BH, Rashid M, Mahmood T, Fatima N. Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L. Plant Cell, Tissue Organ Cult [Internet]. 2010 Jul 6; 102(1):129-34. Available from: http://link.springer.com/10.1007/s11240-010-9712-x https://doi.org/10.1007/s11240-010-9712-x
39. Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, et al. Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells. Williams BO, editor. PLoS One [Internet]. 2013 Jun 18; 8(6):e65889. Available from: https://dx.plos.org/10.1371/journal.pone.0065889 https://doi.org/10.1371/journal.pone.0065889
40. Tasleem F, Azhar I, Ali SN, Perveen S, Mahmood ZA. Analgesic and anti-inflammatory activities of Piper nigrum L. Asian Pac J Trop Med. 2014; 7(S1):S461-8. https://doi.org/10.1016/S1995-7645(14)60275-3
41. Bukhari IA, Alhumayyd MS, Mahesar AL, Gilani AH. The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol. 2013; 64(6). https://doi.org/10.1096/fasebj.27.1_supplement.660.5
42. Jeena K, Liju VB, Umadevi NP, Kuttan R. Antioxidant, Anti-inflammatory and Antinociceptive Properties of Black Pepper Essential Oil ( Piper nigrum Linn). J Essent Oil Bear Plants [Internet]. 2014 Jan 2; 17(1):1-12. Available from: http://www.tandfonline.com/doi/abs/10.1080/0972060X.2013.831562 https://doi.org/10.1080/0972060X.2013.831562
43. Hritcu L, Noumedem JA, Cioanca O, Hancianu M, Postu P, Mihasan M. Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1-42) rat model of Alzheimer's disease. Behav Brain Funct [Internet]. 2015 Dec 29; 11(1):13. Available from: http://behavioralandbrainfunctions.biomedcentral.com/articles/10.1186/s12993-015-0059-7 https://doi.org/10.1186/s12993-015-0059-7
44. Kumar S, Kamboj J, Suman, Sharma S. Overview for Various Aspects of the Health Benefits of Piper Longum Linn. Fruit. JAMS J Acupunct Meridian Stud. 2011; 4(2):134-40. https://doi.org/10.1016/S2005-2901(11)60020-4
45. Vedhanayaki G, Shastri G V., Kuruvilla A. Analgesic activity of Piper longum Linn. root. Indian J Exp Biol. 2003; 41(6):649-51.
46. Vaghasiya Y, Nair R, Chanda S. Investigation of Some Piper Species for Anti-Bacterial and Anti-Inflammatory Property. Int J Pharmacol [Internet]. 2007 Aug 15; 3(5):400-5. Available from: https://www.scialert.net/abstract/?doi=ijp.2007.400.405 https://doi.org/10.3923/ijp.2007.400.405
47. Yende SR, Vrushali D. Sannapuri, Niraj S. Vyawahare, Uday N. Harle. Anti-rheumatoid activity of aqueous extract of Piper longum on Freunds Adjuvant-induced arthritis in rats' Evaluation of Polyhebal formulation for Rheumatoid Arthritis View project. Int J Pharm Sci Res [Internet]. 2010 [cited 2021 Jan 10]; 1(9):129-33. Available from: www.ijpsr.com
48. Nabi SA, Kasetti RB, Sirasanagandla S, Tilak TK, Kumar MVJ, Rao CA. Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats. BMC Complement Altern Med. 2013; 13. https://doi.org/10.1186/1472-6882-13-37
49. Chaudhari GN, Kokate CK, Nimbkar AY. SEARCH FOR ANTHELMINTICS OF PLANT ORIGIN: ACTIVITIES OF VOLATILE PRINCIPLES OF ACORUS CALAMUS against ASCARIS LUMBRICOIDES. Anc Sci Life. 1981;
50. Sharma AK, Kumar S, Chashoo G, Saxena AK, Pandey AK. Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats. Indian J Geo-Marine Sci. 2014; 51(5):358-64.
51. Agrawal AK, Rao C V., Sairam K, Joshi VK, Goel RK. Effect of Piper longum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats. Indian J Exp Biol. 2000; 38(10):994-8.
52. Manoj P, Soniya E, Banerjee N, Ravichandran P. Recent studies on well-known spice, Piper longum Linn. Indian J Nat Prod Resour. 2004;
53. Lakshmi V, Kumar R, Agarwal SK, Dhar JD. Antifertility activity of Piper longum Linn. in female rats. Nat Prod Res. 2006; 20(3):235-9. https://doi.org/10.1080/14786410500045465
54. Bi Y, Qu PC, Wang QS, Zheng L, Liu HL, Luo R, et al. Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson's disease. Pharm Biol. 2015; 53(10):1516-24. https://doi.org/10.3109/13880209.2014.991835
55. Ovadje P, Ma D, Tremblay P, Roma A, Steckle M, Guerrero J-A, et al. Evaluation of the Efficacy & Biochemical Mechanism of Cell Death Induction by Piper longum Extract Selectively in In-Vitro and In-Vivo Models of Human Cancer Cells. Filleur S, editor. PLoS One [Internet]. 2014 Nov 17; 9(11):e113250. Available from: https://dx.plos.org/10.1371/journal.pone.0113250 https://doi.org/10.1371/journal.pone.0113250
56. Kumar S, Sharma S, Vasudeva N. Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism. Expert Opin Pharmacother [Internet]. 2013 Sep 23; 14(13):1723-36. Available from: http://www.tandfonline.com/doi/full/10.1517/14656566.2013.815725 https://doi.org/10.1517/14656566.2013.815725
57. Fathima N, Anwar M, Farooque M, Ahmed T. Evaluation of a Unani formulation, in diabetic peripheral neuropathy: A randomized single blind standard controlled study. Asian J Med Clin Sci. 2012; 1(3).
58. Ara SA, Viquar U, Zakir M, Urooj M, Kazmi MH, Husain GM. Preclinical toxicity evaluation of Habb‐e‐Azaraqi : A nux‐vomica‐based traditional Unani polyherbal formulation in rats . Tradit Kampo Med. 2020; 1-13. https://doi.org/10.1002/tkm2.1263
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