Formulation and Evaluation of Nanoemulgels for the Topical Drug Delivery of Posaconazole

  • Priyanka Priyadarshini Research Student, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India
  • Preeti Karwa Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India https://orcid.org/0000-0002-3367-5237
  • Ayesha Syed Assistant professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India https://orcid.org/0000-0003-3444-1739
  • A.N. Asha Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Abstract

Objective: Posaconazole(POS) is an antifungal drug widely used in treatment of fungal infections. However, the drug has very low oral bioavailability due to high first-pass metabolism, thereby limiting its therapeutic effectiveness. The present study is aimed to prepare nanoemulsion of posaconazole to increase its solubility and to develop posaconazole-loaded nanoemulsion based gel for single dose topical administration to sustain the release of the drug, improve patient compliance and avoid repeated administration.


Method:-FTIR-study was performed to determine compatibility of drug with excipients. Pseudoternary-phase diagram was constructed to optimize the Smix ratio. Optimization of nanoemulsion was done by Box-Behnken Design. The optimized formulation was evaluated for particle-size (nm), polydispersity index (PDI), (%) drug content and in-vitro drug release. POS-nanoemulgel (FNG) was developed using carbopol-934P (1%), which was evaluated for homogeneity, pH, viscosity, spreadability, percentage-yield and in-vitro drug release. The anti-fungal activity of POS-nanoemulgel was evaluated against Candida Albicans.


Results: The FTIR-study confirmed that there was no interaction between drug and excipients. The optimized selected nanoemulsion (FN1) exhibited particle size 79.19nm, PDI 0.357, drug content 95.90% and in-vitro release of 79.40% at 24 hour. The prepared nanoemulgel was homogenous, opaque with good spreadability 13.91±1.19, viscosity 3760±0.014, pH 5.6±0.06 and the zeta-potential was -29mV, indicating good stability. The drug release at 24h was 72.01%. Further, the developed nanoemulgel formulation exhibited better antifungal activity in comparison to the pure drug gel.


Conclusion: Hence, it can be concluded that nanoemulgel of posaconazole can provide better antifungal activity and improve patient compliance.


Keywords: Nanoemulsion, Nanoemulgel, Posaconazole, Anti-fungal, Box-Behnken Design, Pseudoternary phase diagram.

Keywords: Nanoemulsion, Nanoemulgel, Posaconazole, Anti-fungal, Box-Behnken Design, Pseudoternary phase diagram

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Author Biographies

Priyanka Priyadarshini, Research Student, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Research Student, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Preeti Karwa, Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Ayesha Syed, Assistant professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Assistant professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

A.N. Asha, Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru-560027, Karnataka, India

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Priyadarshini P, Karwa P, Syed A, Asha A. Formulation and Evaluation of Nanoemulgels for the Topical Drug Delivery of Posaconazole. JDDT [Internet]. 15Jan.2023 [cited 27Jan.2023];13(1):33-. Available from: https://jddtonline.info/index.php/jddt/article/view/5896