Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review

Abstract

Hypertension elevates the risk of heart disease and stroke which are one of the most frequent causes of death. Fortunately, hypertension is manageable with the use of anti-hypertensives and a healthy lifestyle. However, patient non-adherence to the prescribed dosing regimen is the primary reason for uncontrolled blood pressure levels. Daily multiple doses of medication are one of the major reasons for patient non-compliance to the dosing regimen. Multiple doses of medication are a result of low solubility and high first-pass metabolism of anti-hypertensives. There are several approaches to improve the bioavailability of anti-hypertensives like polymeric and non-polymeric approaches to enhance solubility, avoiding first-pass metabolism through alternate routes of drug delivery and others. The objective of this review is to discuss different approaches to enhance the oral bioavailability of anti-hypertensive drugs.


Keywords: Solubility enhancements, solid lipid nanoparticles, hot melt extrusion, drug delivery, pharmacokinetics, poorly soluble, oral bioavailability.

Keywords: Solubility enhancements, solid lipid nanoparticles, hot melt extrusion, drug delivery, pharmacokinetics, poorly soluble, oral bioavailability

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Author Biographies

Radhika Dole, Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, 506005

Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, 506005

Daniel Kothapally, Chaitanya Deemed to be University, Hanamkonda, Warangal, Telangana, 506001

Chaitanya Deemed to be University, Hanamkonda, Warangal, Telangana, 506001

Sampoorna Chukkala, Talla Padmavathi Pharmacy College, Orus, Kareemabad, Warangal, Telangana, 506002

Talla Padmavathi Pharmacy College, Orus, Kareemabad, Warangal, Telangana, 506002

Ravi Chander Thatipelli, Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, 506005

Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, 506005

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Dole R, Kothapally D, Chukkala S, Thatipelli RC. Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review. JDDT [Internet]. 15May2023 [cited 18May2024];13(5):73-7. Available from: https://jddtonline.info/index.php/jddt/article/view/5814