Effect of Exposure to Soot on Activities of Alanine Transaminase, Gamma Glutamyl Transferase and Lipase among Cooks in Nnewi

Authors

Abstract

Exposure to soot can lead to hepatic and pancreatic dysfunction. This study determined serum alanine transaminase (ALT), gamma-glutamyl transferase (GGT), and triacylglycerol lipase activities of cooks exposed to soot. Thirty (30) participants (cooks) were exposed to soot (test group), and thirty (30) participants not exposed to soot (control group) were recruited. Ethical approval was obtained from the Ethics committee of the Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, and informed consent from the participants was obtained. Alanine transaminase, gamma-glutamyl transferase, and triacylglycerol lipase activities were determined using the spectrophotometric method while the Body mass index (BMI) was calculated using weight (kg)/height2 (m2). An Independent t-test was used for statistical analysis. The results showed that the mean serum activities of alanine transaminase (14.69±1.84), of cooks exposed to soot, were significantly higher compared with the control(12.83±0.94)(p<0.05). The mean serum activities of gamma-glutamyl transferase (7.81±4.08), of cooks exposed to soot, were significantly higher when compared with the control (3.54±2.00)(p<0.05). The mean serum activities of triacylglycerol lipase of cooks exposed to soot were significantly low compared with the control (p<0.05),  while there was no significant difference in the BMI, systolic pressure, and diastolic pressure levels respectively in the test group, compared to the control.  This study observed higher serum activities of alanine transaminase, gamma-glutamyl transferase, and low serum activity of triacylglycerol lipase among cooks exposed to soot, this suggests a predisposition to hepatic and pancreatic dysfunction in the cooks

Keywords: Soot, alanine transaminase, gamma-glutamyl transferase, lipase enzymes

Keywords:

Soot, alanine transaminase, gamma-glutamyl transferase, lipase enzymes

DOI

https://doi.org/10.22270/jddt.v13i4.5793

Author Biographies

Augustine Chinedu Ihim, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Yusuf Habeeb, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Patrick Onochie Manafa, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Emmanuel Ikechukwu Nwobodo, Department of Medical Laboratory Science, Enugu State University, Nigeria

Department of Medical Laboratory Science, Enugu State University, Nigeria

Ukamaka Chima Edward, Department of medical Laboratory Science, Imo state University, Nigeria

Department of medical Laboratory Science, Imo state University, Nigeria

Patrick Chinedu Obi, Faculty of Medicine, Imo state University, Nigeria

Faculty of Medicine,  Imo state University, Nigeria

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Published

15-04-2023
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How to Cite

1.
Ihim AC, Habeeb Y, Manafa PO, Nwobodo EI, Edward UC, Obi PC. Effect of Exposure to Soot on Activities of Alanine Transaminase, Gamma Glutamyl Transferase and Lipase among Cooks in Nnewi. J. Drug Delivery Ther. [Internet]. 2023 Apr. 15 [cited 2025 Feb. 13];13(4):37-41. Available from: https://jddtonline.info/index.php/jddt/article/view/5793

How to Cite

1.
Ihim AC, Habeeb Y, Manafa PO, Nwobodo EI, Edward UC, Obi PC. Effect of Exposure to Soot on Activities of Alanine Transaminase, Gamma Glutamyl Transferase and Lipase among Cooks in Nnewi. J. Drug Delivery Ther. [Internet]. 2023 Apr. 15 [cited 2025 Feb. 13];13(4):37-41. Available from: https://jddtonline.info/index.php/jddt/article/view/5793

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