Effect of Exposure to Soot on Activities of Alanine Transaminase, Gamma Glutamyl Transferase and Lipase among Cooks in Nnewi
Abstract
Exposure to soot can lead to hepatic and pancreatic dysfunction. This study determined serum alanine transaminase (ALT), gamma-glutamyl transferase (GGT), and triacylglycerol lipase activities of cooks exposed to soot. Thirty (30) participants (cooks) were exposed to soot (test group), and thirty (30) participants not exposed to soot (control group) were recruited. Ethical approval was obtained from the Ethics committee of the Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, and informed consent from the participants was obtained. Alanine transaminase, gamma-glutamyl transferase, and triacylglycerol lipase activities were determined using the spectrophotometric method while the Body mass index (BMI) was calculated using weight (kg)/height2 (m2). An Independent t-test was used for statistical analysis. The results showed that the mean serum activities of alanine transaminase (14.69±1.84), of cooks exposed to soot, were significantly higher compared with the control(12.83±0.94)(p<0.05). The mean serum activities of gamma-glutamyl transferase (7.81±4.08), of cooks exposed to soot, were significantly higher when compared with the control (3.54±2.00)(p<0.05). The mean serum activities of triacylglycerol lipase of cooks exposed to soot were significantly low compared with the control (p<0.05), while there was no significant difference in the BMI, systolic pressure, and diastolic pressure levels respectively in the test group, compared to the control. This study observed higher serum activities of alanine transaminase, gamma-glutamyl transferase, and low serum activity of triacylglycerol lipase among cooks exposed to soot, this suggests a predisposition to hepatic and pancreatic dysfunction in the cooks
Keywords: Soot, alanine transaminase, gamma-glutamyl transferase, lipase enzymes
Keywords:
Soot, alanine transaminase, gamma-glutamyl transferase, lipase enzymesDOI
https://doi.org/10.22270/jddt.v13i4.5793References
Agarwal R, Awasthi A, Singh N, Mittal SK, Gupta PK, "Epidemiological study on healthy participants affected by agriculture crop-residue burning episodes and its relation with their pulmonary function tests" Int J Environ Res Public Health 2013; 23(4):281-295. https://doi.org/10.1080/09603123.2012.733933
Chuang HC, Jones TP, Lung SC, BéruBé KA, "Soot-driven reactive oxygen species formation from incense burning" Sci Total Environ 2011; 409(22):4781-4787. https://doi.org/10.1016/j.scitotenv.2011.07.041
Canagaratna MR, Onasch TB, Wood EC, Herndon SC, Jayne JT, Cross ES, Miake-Lye, R C, Kolb CE, Worsnop DR, "Evolution of vehicle exhaust particles in the atmosphere" J Air Waste Manag Assoc 2010; 60(10):1192-1203. https://doi.org/10.3155/1047-3289.60.10.1192
Glaser B, Dreyer A, Bock M, Fiedler S, Mehring M, Heitmann T, "Source Apportionment of Organic Pollutants of a Highway-Traffic-Influenced Urban Area in Bayreuth (Germany) Using Biomarker and Stable Carbon Isotope Signatures" Environ. Sci. Technol. 2005; 39(11):3911-3917. https://doi.org/10.1021/es050002p
Birky MM, Voorhees KJ, "The use of soot analysis as an investigative tool in aircraft fires" Aviat Space Environ Med. 1989; 60(10 Pt 2):B72-77.
Kamboures MA, Hu S, Yu Y, Sandoval J, Rieger P, Huang SM, Zhang S, Dzhema I, Huo D, Ayala A, Chang MCO, "Black carbon emissions in gasoline vehicle exhaust: a measurement and instrument comparison" J Air Waste Manag Assoc 2013; 63(8):886-901. https://doi.org/10.1080/10962247.2013.787130
Victor DG, Ramanathan V, Zaelke D,"Harmful soot spurs climate-policy action" Nat 2014; 517(7532):21-21. https://doi.org/10.1038/517021b
Wang R, Tao S, Shen H, Huang Y, Chen H, Balkanski Y, Boucher O, Ciais P, Shen G, Li W, Zhang Y, Chen Y, Lin N, Su S, Li B, Liu J, Liu W, "Trend in Global Black Carbon Emissions from 1960 to 2007" Environ. Sci. Technol. 2014; 48(12):6780-6787. https://doi.org/10.1021/es5021422
Kim, JW, Park S, Lim CW, Lee K, Kim B, "The Role of Air Pollutants in Initiating Liver Disease" Toxicol. Res. 2014; 30(2):65-70. https://doi.org/10.5487/TR.2014.30.2.065
Tan HH, Fiel MI, Sun Q, Guo, J, Gordon RE, Chen LC, Friedman SL, Odin JA, Allina J, "Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease" J. Immunotoxicol. 2009c; 6(4):266-275. https://doi.org/10.3109/15476910903241704
Pan WC, Wu CD, Chen M.J, Huang YT, Chen CJ, Su HJ, Yang HI, "Fine Particle Pollution, Alanine Transaminase, and Liver Cancer A Taiwanese Prospective Cohort Study (REVEAL-HBV)" J Natl Cancer Inst 2016; 108(3):1-4. https://doi.org/10.1093/jnci/djv341
Ghouri N, Preiss D, Sattar N, "Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease' A narrative review and clinical perspective of prospective data" Hepatol. 2010; 52(3):1156-1161. https://doi.org/10.1002/hep.23789
Center for American Progress. Center for American Progress; Center for American Progress. Charlton M. 2004, "Nonalcoholic fatty liver disease: A review of current understanding and future impact" Clin. Gastroenterol. Hepatol. 2012; 2(12):1048-1058. https://doi.org/10.1016/S1542-3565(04)00440-9
Ihim AC, Okeke O, Manafa PO, Ezejindu DN, Nnodim J, Obi PC," Effect of Exposure To Soot On Troponin I And Lipid Profile Levels" European j. Biomed. pharm. sci 2016;3(2):05-10.
Niranjan R, Thakur AK, "The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black, Focus on Oxidative Stress and Inflammatory Pathways" Front. Immunol. 2017; 1(1)1-3. https://doi.org/10.3389/fimmu.2017.00763
Reitman S, Frankel S, "A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases"Am J Clin Pathol 1957; 28(1):56-63. https://doi.org/10.1093/ajcp/28.1.56
Ihim AC, Iloesie SC, Ogbodo EC, Oguaka VN, Meludu SC, " Effects of regular exercise on the liver function tests of male subjects in the college of health sciences, Nnamdi Azikiwe University, Nnewi campus, Anambra state, Nigeria" Int. J. Curr. Res. Med. 2018; 4(3):73-79. 18. Tietz NW, Shuey DF, Astles JR, "Turbidimetric measurement of lipase activity--problems and some solutions" Clin. Chem.1987; 33(9):1624-1629. https://doi.org/10.1093/clinchem/33.9.1624
Tomao E, Baccolo TP, Sacchi L, Sio SD, Tomei F, "Harm to the liver among employees of the Municipal Police Force" Int J Environ Health Res, 2002;12(2):145-151. https://doi.org/10.1080/09603120220129300
Kim KN, Lee H, Kim JH, Jung K, Lim YH, Hong YC," Physical Activity- and Alcohol-dependent Association Between Air Pollution Exposure and Elevated Liver Enzyme Levels: An Elderly Panel Study" Int J Prev Med 2015; 48(3):151-169. https://doi.org/10.3961/jpmph.15.014
Markevych I, Wolf K, Hampel R, Breitner S, Schneider A, von Klot S, Cyrys J, Heinrich, J, Döring A, Beelen R, Koenig W, Peters A," Air Pollution and Liver Enzymes" Epidemiol. 2013; 24(6):934-935. https://doi.org/10.1097/EDE.0b013e3182a77600
Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R, "Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese pediatric population" Pediatr. Obes. 2017; 13(6):342-347. https://doi.org/10.1111/ijpo.12228
Meng Z, Zhang Q, "Effects of dust storm fine particles instillation on oxidative damage in hearts, livers, lungs of rats" J.Hyg. Res. 2006; 35(6):690-693.
Liu X, Meng Z," Effects of Airborne Fine Particulate Matter on Antioxidant Capacity and Lipid Peroxidation in Multiple Organs of Rats" Inhal Toxicol. 2005; 17(9):467-473. https://doi.org/10.1080/08958370590964467
Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Yasin J, Ali BH, "Pancreatic Effects of Diesel Exhaust Particles in Mice with Type 1 Diabetes Mellitus" Cell. Physiol. Biochem. 2014; 33(2):413-422. https://doi.org/10.1159/000356680
Yi L, Wei C, Fan W, Fine particulate matter (PM2.5), a risk factor of rat gestational diabetes with altered blood glucose and pancreatic GLUT2 expression. Gynecol. Endocrinol. 2017:1-6. https://doi.org/10.1080/09513590.2017.1318368
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