Bioactive Ethnomedicinal Plant Extracts for the Management of Urinary Tract Infection in Pregnancy Women Challenges in Pandemic Period
Abstract
Today urinary tract infection causing Escherichia coli is also serious problem among pregnant women especially during pandemic period. So the mid stream urine samples were collected from different clinics and Public Health Centre in from rural area of Salem city. Totally 25 E. coli was isolated from 25 mid stream urine samples and confirmed by biochemical test and growth parameters. In this study the optimum growth was recorded in pH 7 at 37ᵒC. To date the patterns of resistance to the antimicrobial agents may be due to indiscriminate, wide spread and lengthy use of antibiotics in the treatment of UTI particularly in pandemic situation 2022. So, the present research targeted to extract the therapeutic drug from the high medicinal value of ethano medicinal plant extract because it having anti-UTI compound to diagnose the UTI infection. In this research the antibacterial activity of Terminalia chebula, Allium sativum, Laurus nobilis, Hybamthus enneapermus, Cinnamomum tamala and Zingiber officinale was studied by agar well diffusion method. Four different concentrations (25μl, 50μl, 75μl and 100μl) were used against Escherichia coli. The maximum zone of inhibition were observed in plant extracts Terminalia chebula 11mm, 13mm, 16mm and 20mm in strain no. EC05 followed by minimum zone of inhibition was observed in the plant extract Hybamthus enneapermus 10mm in strain no. EC05 at 100μl concentration of crude plant extracts. The research proved the ethano medicinal plant extract to cleave the pathogenic cell wall of E. coli.
Keywords: E. coli, Urinary tract infection, Pregnancy Women, Medicinal Plant Extracts
Keywords:
E. coli, Urinary tract infection, Pregnancy Women, Medicinal Plant Extracts
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References
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22. Adriana Mirela Tache, Laura Dorina Dinu, Emanuel Vamanu. Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections Adriana Mirela Tache, Laura Dorina Dinu and Emanuel Vamanu. Applied science. 2022; 12(2635):1-17. https://doi.org/10.3390/app12052635
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24. Amit kumar, Neeraj jhadwal, Madan lal, Manjeet singh. Antibacterial activity of some Medicinal Plants used against UTI causing Pathogens. International Journal of Drug Development & Research, 2012; 4(2):278-283.
25. Biswas K, Sinha SN. Antibacterial activity of Tamarindus indica L. against bacteria causing urinary tract infection. Journal of Bio-Science, 2018; 23:47-55. https://doi.org/10.3329/jbs.v23i0.37467
26. Razan Salman Marouf, Joseph Arsene, Mbarga Andrey V, Ermolaev, Irina V, Podoprigora, Irina Smirnova P, Natalia Yashina V, Anna Zhigunova V, Aliya Martynenkova V. Antibacterial activity of medicinal plants against uropathogenic Escherichia coli, J Pharm Bioall Sci, 2022; 14(1):1-12. https://doi.org/10.4103/jpbs.jpbs_124_21
2. Tutuncu L, Ardic N. Urinary Tract Infection in Pregnancy, Prenat Diagn. 2005; 13(4):47.
3. Todar K. Bacteriology, Science Magazine, Vol. 304, pp. 1421, 2008.
4. Ramzan M, Bakhsh S, Salam A, Khan GM, Mustafa G. Risk factor in Urinary tract infection. Gomal J. Med. Sci. 2004; 2:50-53.
5. Russo TA, Johnson JR. Medical and economic impact of extra intestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes and Infection. 2003; 5(5):449-456. https://doi.org/10.1016/S1286-4579(03)00049-2
6. Uwaezuoke JC, Ogbulie JN. Antibiotic sensitivity pattern of urinary tract pathogens in port - Harcourt, Nigeria. J Appl Sci Environ Mgt. 2006; 10:103 - 107. https://doi.org/10.4314/jasem.v10i3.17328
7. Shankel S, Urinary Tract Infections Genitourinary Disorders, The Merck Manuals Online Medical Library, 2007. DOI: 10.12691/ajmr-4-4-3.
8. Raksha R, Srinivasa H, Macaden RS. Occurrence and characterization of uropathogenic Escherichia coli in urinary tract infections. Ind J Med Microbiol. 2003; 21(2):102-107. https://doi.org/10.4103/0974-2727.72152
9. Santo E, Salvador MM, Marin JM, et al. Multidrug resistant urinary tract isolates of Escherichia coli from ribeirao preto, Sao Paulo. Braz. J. Infect. Dis. 2007; 11(6):1-5. https://doi.org/10.1590/S1413-86702007000600010
10. Addisu Assefa, Daniel Asrat, Yimtubezinash Woldeamanuel, Yirgu Hiwot G, Ahmed Abdella Tadele Melesse. Original Article bacterial profile and drug susceptibility pattern of urinary tract infection in pregnant women at tikur anbessa specialized hospital Addis Ababa, Ethiopia. Ethiop Med J. 2008; 46 (3):227-235.
11. Fantahun B, Bayeh A. Antimicrobial resistance of bacterial isolates from urinary tract infection at Felge Hiwot Referral Hospital, Ethopia. Ethiopian Journal of Health Development. 2009; 23(3):236-238. https://doi.org/10.4314/ejhd.v23i3.53248
12. Piatti G, Mannini A, Balistreri M, Schito AM. Virulence factors in urinary Escherichia coli strains: phylogenetic background and quinolone and fluoroquinolone resistance. Journal of Clinical Microbiology. 2008; 46(2):480-487. https://doi.org/10.1128/JCM.01488-07
13. Vasquez Y, HW A. Antibiotic susceptibility patterns of community-acquired urinary
tract isolates from female patients on the US (Texas)-Mexico border. The Journal of Applied Research. 2004; 4: 321-326.
14. Gold HS, Moellering RC. Antimicrobial drug resistance. N Eng J Med. 1996; 335:1445-1453. https://doi.org/10.1056/NEJM199611073351907
15. Ludden C, Cormican M, Vellinga A, Johnson JR, Austin B, Morris D. Colonization with ESBL - producing and carbapenemase-producing Enterobacteriaceae, vancomycin-resistant Enterococci, and methicillin-resistant Staphylococcus aureus in a long-term care facility over one year. BMC Infect. Dis. 2015; 15:168. https://doi.org/10.1186/s12879-015-0880-5
16. Shriram V, Khare T, Bhagwat R, Shukla R and Kumar V. Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance," Front. Microbiol. 2018; 9: 2990. https://doi.org/10.3389/fmicb.2018.02990
17. Frost I, Van Boeckel TP, Pires J, Craig J, Laxminarayan R. Global geographic trends in antimicrobial resistance: the role of international travel. J Travel Med. 2019; 25(8):1-13. https://doi.org/10.1093/jtm/taz036
18. Prestinaci F, Pezzotti P. Antimicrobial resistance: A global multifaceted phenomenon. Pathogens and global health, Pathog Glob Health, 2015; 109(7):309-318, 2015. https://doi.org/10.1179/2047773215Y.0000000030
19. Porooshat Dadgostar. Antimicrobial Resistance: Implications and Costs. Infect Drug Resist. 2019; 12: 3903-3910. https://doi.org/10.2147/IDR.S234610
20. Brown ED, Wright GD. Antibacterial drug discovery in the resistance era. Nature. 2016; 529:336-343. https://doi.org/10.1038/nature17042
21. WHO, Resistance: a global multifaceted phenomenon, Pathogens and global health, 2019; 109(7):309-318. https://doi.org/10.1179/2047773215Y.0000000030
22. Adriana Mirela Tache, Laura Dorina Dinu, Emanuel Vamanu. Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections Adriana Mirela Tache, Laura Dorina Dinu and Emanuel Vamanu. Applied science. 2022; 12(2635):1-17. https://doi.org/10.3390/app12052635
23. Ziad Daoud. Escherichia coli isolated from urinary tract infections of Lebanese patients between 2000 and 2009: epidemiology and profiles of resistance, Chemotherapy research and practice, 2011: 1-7. https://doi.org/10.1155/2011/218431
24. Amit kumar, Neeraj jhadwal, Madan lal, Manjeet singh. Antibacterial activity of some Medicinal Plants used against UTI causing Pathogens. International Journal of Drug Development & Research, 2012; 4(2):278-283.
25. Biswas K, Sinha SN. Antibacterial activity of Tamarindus indica L. against bacteria causing urinary tract infection. Journal of Bio-Science, 2018; 23:47-55. https://doi.org/10.3329/jbs.v23i0.37467
26. Razan Salman Marouf, Joseph Arsene, Mbarga Andrey V, Ermolaev, Irina V, Podoprigora, Irina Smirnova P, Natalia Yashina V, Anna Zhigunova V, Aliya Martynenkova V. Antibacterial activity of medicinal plants against uropathogenic Escherichia coli, J Pharm Bioall Sci, 2022; 14(1):1-12. https://doi.org/10.4103/jpbs.jpbs_124_21
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Vijayalakshmi S, Mohankumar A. Bioactive Ethnomedicinal Plant Extracts for the Management of Urinary Tract Infection in Pregnancy Women Challenges in Pandemic Period. JDDT [Internet]. 15Mar.2023 [cited 22Mar.2023];13(3):30-6. Available from: https://jddtonline.info/index.php/jddt/article/view/5756
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