Formulation of Hair Tonic from Ethanol Extract of Sea Hibiscus (Hibiscus tileaceus L.) Leaves in Promoting Hair Growth on Guinea Pig (Cavia porcellus)
Abstract
Hair loss is an unavoidable process, as the age increase, the rate of hair growth also slows down. Hair loss is caused by many factors and occur in different areas of body. Since hair become one of the major aspect for women beauty, hair loss will become a serious problem if it is not solved. Many plants or their extracts have been used to reduce hair loss. The leaves of sea hibiscus (Hibiscus tiliaceus L.) have been known empirically to promote hair growth and prevent hair loss. The leaves contain saponin, flavonoid, and also polyphenol compounds. The purpose of this study was to formulate sea hibiscus leaf extract into hair tonic preparations and evaluate the activity in triggering hair growth. In this research, tested animals were divided into 5 groups: F0 (blank) as a negative control, F1 (20%), FII (25%), FIII (30%) extract of sea hibiscus leaves and minoxidil as positive control. All preparations made were kept in room temperature for 12 weeks and the pH value test was carried out in first, fourth, eighth and twelfth week. The hair growth activity was done by applying hair tonic to the guinea pig and hair was randomly plucked from test area measuring hair length using calliper on the 7th, 14th, 21st days. On the 21st day, hair tonic of 30% sea hibiscus leaf extract showed a great activity on the growth of hair length with an average of 17.2633 mm and weighed an average of 0.145g, with a significant difference compared to another formula (p < 0.05).
Keywords: Hair tonic, Hibiscus tiliaceus, Sea Hibiscus Leaves
Downloads
References
2. Ambarwati NSS, Supiani T, Laksmi NA, Atmanto D, "Improvement of Welfare with The Utilization of Aloe vera for Scalp and Hair Care" JKKP, 2020; 7:117-129. https://doi.org/10.21009/JKKP.072.01
3. Qu X, Niu L, Kroon B, Foltis L. "Pollution Damage and Protection of Asian Hair" Cosmetics, 2018; 5:1-9. https://doi.org/10.3390/cosmetics5010017
4. Cosgrove D, Zallocchi M, "Usher protein functions in hair cells and photoreceptors" Int. J. Biochem Cell Biol, 2014; 46:80-89. https://doi.org/10.1016/j.biocel.2013.11.001
5. Randall VA, "Androgens and Hair Growth" Dermatol Ther, 2008; 21:314-328. https://doi.org/10.1111/j.1529-8019.2008.00214.x
6. Indrawati T, Simanjuntak L, Pratami DK, Hair Tonic Shampoo Formulation with Ambon Banana (Musa Acuminata COLLA) Corm Extract" Int. J. Appl. Pharm, 2020; 12:1-7. https://doi.org/10.22159/ijap.2020v12i5.37918
7. Wolfarm LJ, "Human Hair: A Unique Physicochemical" J. Am. Acad. Dermatol, 2003; 48:106-114. https://doi.org/10.1067/mjd.2003.276
8. Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR, "Hair as a Biomarker of Environmental Manganese Exposure" Environ. Sci. Technol, 2013; 47:1629-1637 https://doi.org/10.1021/es3035297
9. Bolduc C, Shapiro J, "Hair Care Products: Waving, Straightening, Conditioning, and Coloring. Clin. Dermatol" 2001; 19: 431-436. https://doi.org/10.1016/S0738-081X(01)00201-2
10. Awal SMA, Nazmir S, Nasrin S, Nurunnabi TR, Uddin SJ, "Evaluation of Pharmacological Activity of Hibiscus tiliaceus" Springerplus, 2016; 5:1209. https://doi.org/10.1186/s40064-016-2891-0
11. Melecchi MIS, Martinez MM, Abad FC, Zini PP, Alegre P, "Chemical Composition of Hibiscus tiliaceus L. flowers : A Study of Extraction Methods Microcolumn Separations" J. Sep. Sci, 2002; 25:86-9 https://doi.org/10.1002/1615-9314(20020101)25:1/2<86::AID-JSSC86>3.0.CO;2-7
12. Fitri K, Khairani T, Sianturi KT, Leny L, Hafiz I, "Anti-inflammatory Activity of Ethanol Extract of Lotus (Nelumbo nucifera G.) Seed Against White Male Rats Using Paw Edema Method" Journal of Drug Delivery and Therapeutics, 2021: 11(4):1-4. https://doi.org/10.22270/jddt.v11i4.4918
13. Leny, Fitri K, Marantina R, et al., "The Moisturizing Sheet Mask Formulation of Black Soybean (Glycine soja) Ethanolik Extract" International Journal of Advanced Science and Technology, 2020; 29(4):9045-9051.
14. Ginting P, Leny, Hafiz I, Hasibuan R, "Formulation of Anti Acne Sheet Mask from Bandotan Leaf Extract (Ageratum conyzoides L.) against Propionibacterium acnes" Journal of Drug Delivery and Therapeutics, 2021; 11(6-S):123-127, DOI: https://doi.org/10.22270/jddt.v11i6-S.5240
15. Leny, Karsono, Harahap U, "Comparison of Vitamin C (Magnesium Ascorbyl Phosphate) Formulation in Nanoemulsion Spray and Cream as Anti-aging" International Journal of PharmTech Research, 2016; 9(9):399-407.
16. Lodha G, "Formulation and Evaluation of Polyherbal Shampoo to Promote Hair Growth and Provide Antidandruff Action" J. Drug Deliv. Ther, 2019; 9:296-300 https://doi.org/10.22270/jddt.v9i4-A.3474
17. Chandra P, Reveny J, Nainggolan M, "Formulation and Evaluation of Hair Tonic Gel Preparation Resistace Water Fraction N-Hexan Fruit Curm (Phoenix dactylifera L.)" Asian J. Pharm. Res. Dev, 2020; 8:4-6.
18. Satheeshan KN, Seema BR, Manjusha AVM. Development and evaluation of VCO based herbal hair tonic. J. Pharmacogn. Phytochem, 2020; 9:485-493.
19. Wijaya WH, Munim A, Djajadisastra J, "Effectiveness Test of Fenugreek Seed (Trigonella foenum-graecum L.) Extract Hair Tonic in Hair Growth Activity" Int. J. Curr. Res, 2013; 5:3453-3460.
20. Lavy E, Goldberger D, Friedman M, Steinberg D, "pH Values and Mineral Content of Saliva in Different Breeds of Dogs" Isr. J. Vet. Med, 2012; 67:244-248.
21. Indriaty S, Indrawati T, Taurhesia S, "Formulation and test activities of hair tonic with a combination of the aqueous extracts of aloe vera (Aloe vera L.) and licorice (Glycyrrhiza glabra L.). Pharmaciana, 2018; 8:33-42. https://doi.org/10.12928/pharmaciana.v8i1.8877
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.