Formulation of Hair Tonic from Ethanol Extract of Sea Hibiscus (Hibiscus tileaceus L.) Leaves in Promoting Hair Growth on Guinea Pig (Cavia porcellus)

  • Leny Leny Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia
  • Khairani Fitri Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia
  • Yudita Kharani Lase Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia
  • Ihsanul Hafiz Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia
  • Benni Iskandar Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau, Riau, Indonesia

Abstract

Hair loss is an unavoidable process, as the age increase, the rate of hair growth also slows down. Hair loss is caused by many factors and occur in different areas of body. Since hair become one of the major aspect for women beauty, hair loss will become a serious problem if it is not solved. Many plants or their extracts have been used to reduce hair loss. The leaves of sea hibiscus (Hibiscus tiliaceus L.) have been known empirically to promote hair growth and prevent hair loss. The leaves contain saponin, flavonoid, and also polyphenol compounds. The purpose of this study was to formulate sea hibiscus leaf extract into hair tonic preparations and evaluate the activity in triggering hair growth. In this research, tested animals were divided into 5 groups: F0 (blank) as a negative control, F1 (20%), FII (25%), FIII (30%) extract of sea hibiscus leaves and minoxidil as positive control.  All preparations made were kept in room temperature for 12 weeks and the pH value test was carried out in first, fourth, eighth and twelfth week. The hair growth activity was done by applying hair tonic to the guinea pig and hair was randomly plucked from test area measuring hair length using calliper on the 7th, 14th, 21st days. On the 21st day, hair tonic of 30% sea hibiscus leaf extract showed a great activity on the growth of hair length with an average of 17.2633 mm and weighed an average of 0.145g, with a significant difference compared to another formula (p < 0.05).


Keywords: Hair tonic, Hibiscus tiliaceus, Sea Hibiscus Leaves

Keywords: Hair tonic, Hibiscus tiliaceus, Sea Hibiscus Leaves

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Author Biographies

Leny Leny, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Khairani Fitri, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Yudita Kharani Lase, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Ihsanul Hafiz, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan 20124, Indonesia

Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia

Benni Iskandar, Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau, Riau, Indonesia

School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan

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Leny L, Fitri K, Lase YK, Hafiz I, Iskandar B. Formulation of Hair Tonic from Ethanol Extract of Sea Hibiscus (Hibiscus tileaceus L.) Leaves in Promoting Hair Growth on Guinea Pig (Cavia porcellus). JDDT [Internet]. 15Mar.2022 [cited 25Sep.2022];12(2):1-. Available from: https://jddtonline.info/index.php/jddt/article/view/5364