Coating Processes of Pharmaceutical Applicability: A Glimpse


  • Mahammed Athar Alli Saikh Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India, 764 005


Presentation of manuscript is aiming to furnish glimpse on coating processes. Coating is process of snugly covering substrate surface with coating materials (CoM). In due course coating process has gradually developed from sugar-coating to non-aqueous film-coating to aqueous film-coating to specialised-coating processes. In second half of past century sugar-coating was first choice for pharmaceutical industry. Lengthy and tedious processing along with issues of skilled-operator inherited to sugar-coating compelled them to spring-up and improve film-coating. From past five decades, volatile organic solvent (VOS) are preferred over water in film-coating. Momentum for using aqueous solvent in film-coating gets accelerated from past few decades. Nowadays these replacing the VOS based film-coating processes as later inherit issues relating toxicity; safety; worker hygiene & safety; environmental pollution; etc. During process of finding novelty of coating another exploited sphere is coating of particulate substrate surfaces with CoM is to confer them worthy functionalities and applications. In this area both wet- & dry-coating process finds applicability thru modifying and/or altering innate properties of substrate, physically and/or chemically. Dry-coating process basically comprises specialised and novel process & technologies. Nowadays there available numerous conventional, specialised, and novel coating processes. Amongst them state-of-art process are hot-melt coating (HMC) process, aqueous film-coating process, aerosolized coating process, Supercell® coating process, gas-/ vapour-phase process, photo curable coating process, electrical-electrostatic deposition process, Resonant acoustic coating process, thermal and mechanical process, thermo-mechanical process, fluidised-bed processes, etc. Herein conventional, specialised, and novel coating processes are briefed, to update professionals.

Keywords: Coating, film-coating, novel, process, specialised.

Keywords: Coating, film-coating, novel, process, specialised


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Author Biography

Mahammed Athar Alli Saikh, Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India, 764 005

Professor and HOD, Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India, 764 005



1. Saikh MAA. Pharmaceutical’s Coating. Germany: LAP Lambert Academic Publishing; 2015.
2. Koner JS, Wyatt DA, Dahmash EZ., Mohammed A. Dry particle coating—a unique solution for pharmaceutical formulation. Pharmaceutical Technology, 2018; 42(3):26–30.
3. Saikh MAA. Dry-coating of powder particles is current trend in pharmaceutical field. Journal of Drug Delivery and Therapeutics, 2021; 11(5):145-157. DOI:
4. Nakamura S, Sakamoto T, Ito T, Kabasawa K, Yuasa H. Preparation of controlled-release fine particles using a dry coating method. AAPS PharmSciTech, 2016; 17:1393–1403.
5. Saikh MAA, Aqueous film coating the current trend. Journal of Drug Delivery and Therapeutics, 2021; 11(4-s):212-224. DOI:
6. Ahmed SAN, Patil SR, Khan MKS, Khan MS. Tablet coating techniques: Concept and recent trends. International Journal of Pharmaceutical Sciences Review and Research, 2021; 66(1):43-53.
7. Arora R, Rathore KS, Bharkatiya M. An overview on tablet coating. Asian Journal of Pharmaceutical Research and Development, 2019; 7(4):89-92. DOI:
8. Zaid AN. A Comprehensive review on pharmaceutical film coating: Past, present, and future. Drug Design Development and Therapy, 2020; 14:4613-4623.
9. Seo KS, Bajracharya R, Lee SH, Han HK. Pharmaceutical application of tablet film coating. Pharmaceutics, 2020; 12(9):853. DOI:
10. Saikh MAA. Film former in film coating. International Journal of Pharmaceutical Sciences and Research, 2022; 13(4): [In press]
11. Saikh MAA. A comprehensive review on coating pans. International Journal of Pharmaceutical Sciences and Research, 2022; 13(5): [In press]
12. Saikh MAA, Mohapatra P. Thermo-mechanical dry coating as dry coating process is for pharmaceutical. Journal of Drug Delivery and Therapeutics, 2021; 11(6):176-187. DOI:
13. Singhai NJ, Rawal A, Maurya R, Suman R. Design and characterization of dual drug loaded microspheres for colon drug targeting. Journal of Drug Delivery and Therapeutics, 2019; 9(3-s):12-22. DOI:
14. Gaware RU, Tambe ST, Dhobale SM, Jadhav SL. Formulation and in-vitro evaluation of theophylline sustained release tablet. Journal of Drug Delivery and Therapeutics, 2019; 9(1-s):48-51. DOI:
15. Saikh MAA. Dry coating of pharmaceutical powders. International Journal of Pharmaceutical Sciences and Research, 2022; 13(7): [In press]
16. Saikh MAA, Mohapatra P. Specialised coating processes finding pharmaceutical applicability. Journal of Drug Delivery and Therapeutics, 2021; 11(6):209-224. DOI:
17. Pundir K, Parashar B. The innovations in tablet coating: A review. International Educational Applied Research Journal, 2019; 3(6):18-23.
18. Yang Q, Yuan F, Xu L, Yan Q, Yang Y, Wu D, Guo F, Yang G. An update of moisture barrier coating for drug delivery. Pharmaceutics, 2019; 11(9):436. DOI:
19. Yang Q, Ma Y, Zhu J. Dry powder coated osmotic drug delivery system. European Journal of Pharmaceutical Sciences, 2018; 111:383-392. DOI:
20. Foppoli AA, Maroni A, Cerea M, Zema L, Gazzaniga A. Dry coating of solid dosage forms: An overview of processes and applications. Drug Development and Industrial Pharmacy, 2017; 43(12):1919-1931.
21. Bungert N, Kobler M, Scherließ R. In-depth comparison of dry particle coating processes used in dpi particle engineering. Pharmaceutics, 2021; 13(4):580. DOI:
22. Sharma R, Setia G. Mechanical dry particle coating on cohesive pharmaceutical powders for improving flowability - A review. Powder Technology, 2019; 356:458-479, DOI:
23. Zhang R, Hoffmann T, Tsotsas E. Novel technique for coating of fine particles using fluidized bed and aerosol atomizer. Processes, 2020; 8:1525. DOI:
24. Bannow J, Koren L, Salar-Behzadi S, Löbmann K, Zimmer A, Rades T. Hot melt coating of amorphous Carvedilol. Pharmaceutics, 2020; 12(6):519. DOI:
25. Salar-Behzadi S, Corzo C, Gomes Lopes D, Meindl C, Lochmann D, Reyer S. Novel approach for overcoming the stability challenges of lipid-based excipients. Part 2: Application of polyglycerol esters of fatty acids as hot melt coating excipients. European Journal of Pharmaceutics and Biopharmaceutics, 2020; 148:107-117. DOI:
26. Salar-Behzadi S, Corzo C, Schaden L, Laggner P, Zimmer A. Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules. International Journal of Pharmaceutics, 2019; 565:569-578. DOI:
27. Stocker E, Becker K, Hate S, Hohl R, Schiemenz W, Sacher S, Zimmer A, Salar-Behzadi S. Application of ICH Q9 quality risk management tools for advanced development of hot melt coated multiparticulate systems. Journal of Pharmaceutical Sciences, 2017; 106(1):278-290. DOI:
28. Zier KI, Schultze W, Leopold CS. Combination of a hot-melt subcoating and an enteric coating for moisture protection of hygroscopic Sennae fructus tablets. Pharmaceutical Development and Technology, 2019; 24(10):1210-1217. DOI:
29. Wang X, Wang P, Huang C, Lin X, Gong H, He H, Cai C. Hot-melt sub- and outer coating combined with enteric aqueous coating to improve the stability of aspirin tablets. Asian Journal of Pharmaceutical Sciences, 2017; 12(3):266-278. DOI:
30. Guimarães TF, Comelli ACC, Tacón LA, Cunha TA, Marreto RN, Freitas LAP. Fluidized bed hot melt granulation with hydrophilic materials improves Enalapril maleate stability. AAPS PharmSciTech, 2017; 18(4):1302-1310. DOI:
31. Schertel S, Salar-Behzadi S, Karrer J, Laggner P, Zimmer A. Impact of polysorbate 65 on tripalmitin crystal growth and release stability of hot melt coated multiparticulate systems. International Journal of Pharmaceutics, 2021; 607:120970. DOI:
32. Schertel S, Salar-Behzadi S, Zimmer A. Impact of surface properties of core material on the stability of hot melt-coated multiparticulate systems. Pharmaceutics, 2021; 13(3):366. DOI:
33. Lopes DG, Salar-Behzadi S, Zimmer A. Designing optimal formulations for hot-melt coating. International Journal of Pharmaceutics, 2017; 533(2):357-363. DOI:
34. Jedinger N, Schrank S, Fischer JM, Breinhälter K, Khinast J, Roblegg E. Development of an abuse- and alcohol-resistant formulation based on hot-melt extrusion and film coating. AAPS PharmSciTech, 2016; 17(1):68-77. DOI:
35. Yang Y, Shen L, Li J, Shan WG. Preparation and evaluation of Metoprolol tartrate sustained-release pellets using hot melt extrusion combined with hot melt coating. Drug Development and Industrial Pharmacy, 2017; 43(6):939-946. DOI:
36. Milanovic A, Aleksic I, Ibric S, Parojcic J, Cvijic S. Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets. European Journal of Pharmaceutical Sciences, 2020; 142:105121. DOI:
37. Liu Y, Doddi J, Zheng Y, Ho V, Pheil M, Shi Y. Transmission raman spectroscopic quantification of active pharmaceutical ingredient in coated tablets of hot-melt extruded amorphous solid dispersion. Applied Spectroscopy, 2020; 74(1):108-115. DOI:
38. Huang H, Wu Z, Qi X, Zhang H, Chen Q, Xing J, Chen H, Rui Y. Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: In vitro and in vivo evaluation. International Journal of Pharmaceutics, 2013; 446(1-2):211-218. DOI:
39. Ozeki Y, Ando M, Watanabe Y, Danjo K. Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tablets. Journal of Controlled Release, 2004; 95(1):51-60. DOI:
40. Koskela J, Morton DAV, Stewart PJ, Juppo AM, Lakio S. The effect of mechanical dry coating with magnesium stearate on flowability and compactibility of plastically deforming microcrystalline cellulose powders. International Journal of Pharmaceutics 2018; 537(1-2):64-72.
41. Gera M, Saharan VA, Kataria M, Kukkar V. Mechanical methods for dry particle coating processes and their applications in drug delivery and development. Recent Patents on Drug Delivery & Formulation, 2010; 4(1):58-81.
42. Quinlan L, Morton DAV, Zhou Q. Particle engineering via mechanical dry coating in the design of pharmaceutical solid dosage forms. Current Pharmaceutical Design, 2015; Article Number 21(999). DOI:
43. Qu L, Stewart PJ, Hapgood KP, Lakio S, Morton DAV, Zhou QT. Single-step coprocessing of cohesive powder via mechanical dry coating for direct tablet compression. Journal of Pharmaceutical Sciences, 2017; 106(1):159-167. DOI:
44. Jeon IS, Lee MH, Choi HH, Lee S, Chon JW, Chung DJ, Park JH, Jho JY. Mechanical properties and bioactivity of Polyetheretherketone/Hydroxyapatite/Carbon fiber composite prepared by the mechanofusion process. Polymers (Basel), 2021; 13(12):1978. DOI:
45. Matsumoto A, Ono A, Murao S, Murakami M. Microparticles for sustained release of water-soluble drug based on a containment, dry coating technology. Drug Discoveries & Therapeutics, 2018; 12(6):347-354. DOI:
46. Li M, Zhang L, Davé RN, Bilgili E. An intensified vibratory milling process for enhancing the breakage kinetics during the preparation of drug nanosuspensions. AAPS PharmSciTech, 2016; 17(2):389-399. DOI:
47. Tanaka R, Osotprasit S, Peerapattana J, Ashizawa K, Hattori Y, Otsuka M. Complete cocrystal formation during resonant acoustic wet granulation: Effect of granulation liquids. Pharmaceutics. 2021; 13(1):56. DOI:
48. Buyukgoz GG, Castro JN, Atalla AE, Pentangelo JG, Tripathi S, Davé RN. Impact of mixing on content uniformity of thin polymer films containing drug micro-doses. Pharmaceutics, 2021; 13(6):812. DOI:
49. Zhang L, Alfano J, Race D, Davé RN. Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. European Journal of Pharmaceutical Sciences, 2018; 117:245-254. DOI:
50. Zhang L, Aloia M, Pielecha-Safira B, Lin H, Rajai PM, Kunnath K, Davé RN. Impact of superdisintegrants and film thickness on disintegration time of strip films loaded with poorly water-soluble drug microparticles. Journal of Pharmaceutical Sciences, 2018; 107(8):2107-2118. DOI:
51. Prasad LK, McGinity JW, Williams RO 3rd. Electrostatic powder coating: Principles and pharmaceutical applications. International Journal of Pharmaceutics, 2016; 505(1-2):289-302. DOI:
52. Yang Q, Ma Y, Zhu J. Applying a novel electrostatic dry powder coating technology to pellets. European Journal of Pharmaceutics and Biopharmaceutics, 2015; 97(PtA):118-124. DOI:
53. Yang Q, Ma Y, Zhu J. Sustained drug release from electrostatic powder coated tablets with ultrafine Ethylcellulose powders. Advanced Powder Technology, 2016; 27(5):2145–2152. DOI:
54. Yang Y, Shen L, Yuan F, Fu H, Shan W. Preparation of sustained release capsules by electrostatic dry powder coating, using traditional dip coating as reference. International Journal of Pharmaceutics, 2018; 543(1-2):345-351. DOI:
55. Soh SH, Lee LY. Microencapsulation and nanoencapsulation using supercritical fluid (SCF) techniques. Pharmaceutics, 2019; 11(1):21. DOI:
56. Trivedi V, Bhomia R, Mitchell JC. Myristic acid coated protein immobilised mesoporous silica particles as ph induced oral delivery system for the delivery of biomolecules. Pharmaceuticals (Basel), 2019; 12(4):153. DOI:
57. Chen LF, Xu PY, Fu CP, Kankala RK, Chen AZ, Wang SB. Fabrication of supercritical antisolvent (SAS) process-assisted Fisetin-encapsulated poly (vinyl pyrrolidone) (PVP) nanocomposites for improved anticancer therapy. Nanomaterials (Basel), 2020; 10(2):322. DOI:
58. Sheth P, Sandhu H, Singhal D, Malick W, Shah N, Kislalioglu MS. Nanoparticles in the pharmaceutical industry and the use of supercritical fluid technologies for nanoparticle production. Current Drug Delivery, 2012; 9(3):269-284. DOI:
59. Amania M, Saadati N, Navid A, Majda Y. Utilization of supercritical CO2 gas antisolvent (GAS) for production of Capecitabine nanoparticles as anti-cancer drug: Analysis and optimization of the process conditions. Journal of CO2 Utilization, 2021; 46:101465. DOI:
60. Silva JM, Akkache S, Araújo AC, Masmoudi Y, Reis RL, Badens E, Duarte ARC. Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes. Materials Science & Engineering. C, Materials for Biological Applications, 2019; 99:599-610. DOI:
61. Perinelli DR, Cespi M, Bonacucina G, Naylor A, Whitaker M, Lam JK, Howdle SM, Casettari L, Palmieri GF. PEGylated biodegradable polyesters for pgss microparticles formulation: Processability, physical and release properties. Current Drug Delivery, 2016; 13(5):673-681. DOI:
62. Perrotta A, Werzer O, Coclite AM. Strategies for drug encapsulation and controlled delivery based on vapor-phase deposited thin films. Advanced Engineering Materials, 2017; 20:1700639. DOI:,
63. Unger K, Coclite AM. Conformal coating of powder by initiated chemical vapor deposition on vibrating substrate. Pharmaceutics, 2020; 12(9):904.
64. Christian P, Ehmann HM, Coclite AM, Werzer O. Polymer encapsulation of an amorphous pharmaceutical by initiated chemical vapor deposition for enhanced stability. ACS Applied Materials & Interfaces, 2016; 8(33):21177-21184. DOI:
65. Christian P, Ehmann HM, Werzer O, Coclite AM. Wrinkle formation in a polymeric drug coating deposited via initiated chemical vapor deposition. Soft Matter, 2016; 12(47):9501-9508. DOI:
66. Tylinski M, Smith RS, Kay BD. Morphology of vapor-deposited acetonitrile films. Journal of Physical Chemistry A, 2020; 124(30):6237-6245. DOI:
67. Wack S, Lunca Popa P, Adjeroud N, Vergne C, Leturcq R. Two-Step approach for conformal chemical vapor-phase deposition of ultra-thin conductive silver films. ACS Applied Materials & Interfaces, 2020; 12(32):36329-36338. DOI:
68. Li H, Gao Y, Shao Y, Su Y, Wang X. Vapor-Phase atomic layer deposition of CO9S8 and its application for supercapacitors. Nano Letters, 2015; 15(10):6689-6695. DOI:
69. Santino LM, Hwang E, Diao Y, Lu Y, Wang H, Jiang Q, Singamaneni S, D'Arcy JM. Condensing vapor phase polymerization (cvpp) of electrochemically capacitive and stable polypyrrole microtubes. ACS Applied Materials & Interfaces, 2017; 9(47):41496-41504. DOI:
70. Geng C, Trussler S, Johnson MB, Zaker N, Scott B, Botton G, Dahn JR. A low-cost instrument for dry particle fusion coating of advanced electrode material particles at the laboratory scale. Journal of The Electrochemical Society, 2020; 167:110509.
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Saikh MAA. Coating Processes of Pharmaceutical Applicability: A Glimpse. JDDT [Internet]. 15Mar.2022 [cited 18May2024];12(2):126-38. Available from: