Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals
The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field.
Keywords: dry coating, equipment, particles, processes, thermo-mechanical.
2. Saikh MAA. Pharmaceutical’s Coating. Germany: LAP Lambert Academic Publishing; 2015.
3. Koner JS, Wyatt DA, Dahmash EZ., Mohammed A. Dry particle coating—a unique solution for pharmaceutical formulation. Pharmaceutical Technology, 2018, 42(3):26–30.
4. Nakamura S, Sakamoto T, Ito T, Kabasawa K, Yuasa H. Preparation of controlled-release fine particles using a dry coating method. AAPS PharmSciTech, 2016; 17:1393–1403.
5. Zhang R, Hoffmann T, Tsotsas E. Novel technique for coating of fine particles using fluidized bed and aerosol atomizer. Processes, 2020; 8:1525. DOI: https://dx.doi.org/10.3390/pr8121525.
6. Saikh MAA, Aqueous film coating the current trend. Journal of Drug Delivery and Therapeutics, 2021; 11(4-s):212-224. DOI: https://dx.doi.org/10.22270/jddt.v11i4-S.4911.
7. Saikh MAA. Film former in film coating. International Journal of Pharmaceutical Sciences and Research, 2022; 13(4): [In press]
8. Saikh MAA. A comprehensive review on coating pans. International Journal of Pharmaceutical Sciences and Research, 2022; 13(5): [In press]
9. Ahmed SAN, Patil SR, Khan MKS, Khan MS. Tablet coating techniques: Concept and recent trends. International Journal of Pharmaceutical Sciences Review and Research, 2021; 66(1):43-53.
10. Singhai NJ, Rawal A, Maurya R, Suman R. Design and characterization of dual drug loaded microspheres for colon drug targeting. Journal of Drug Delivery and Therapeutics, 2019; 9(3-s):12-22. DOI: https://dx.doi.org/10.22270/jddt.v9i3-s.2923.
11. Gaware RU, Tambe ST, Dhobale SM, Jadhav SL. Formulation and in-vitro evaluation of theophylline sustained release tablet. Journal of Drug Delivery and Therapeutics, 2019; 9(1-s):48-51. DOI: https://dx.doi.org/10.22270/jddt.v9i1-s.2252.
12. Divya B, Sreekanth J, Satyavati D. Development of extended release formulations of Ilaprazole tablets. Journal of Drug Delivery and Therapeutics, 2019; 9(3):8-12. DOI: https://dx.doi.org/10.22270/jddt.v9i3.2811.
13. Sharma R, Setia G. Mechanical dry particle coating on cohesive pharmaceutical powders for improving flowability - A review. Powder Technology, 2019; 356:458-479, DOI: https://dx.doi.org/10.1016/j.powtec.2019.08.009.
14. Christian P, Ehmann HM, Coclite AM, Werzer O. Polymer encapsulation of an amorphous pharmaceutical by initiated chemical vapor deposition for enhanced stability. ACS Applied Materials & Interfaces, 2016; 8(33):21177-21184. DOI: https://dx.doi.org/10.1021/acsami.6b06015.
15. Christian P, Ehmann HM, Werzer O, Coclite AM. Wrinkle formation in a polymeric drug coating deposited via initiated chemical vapor deposition. Soft Matter, 2016; 12(47):9501-9508. DOI: https://dx.doi.org/10.1039/c6sm01919f.
16. Perrotta A, Werzer O, Coclite AM. Strategies for drug encapsulation and controlled delivery based on vapor-phase deposited thin films. Advanced Engineering Materials, 2017; 20:1700639. DOI: https://dx.doi.org/10.1002/adem.201700639,
17. Tylinski M, Smith RS, Kay BD. Morphology of vapor-deposited acetonitrile films. Journal of Physical Chemistry A, 2020; 124(30):6237-6245. DOI: https://dx.doi.org/10.1021/acs.jpca.0c03650.
18. Wack S, Lunca Popa P, Adjeroud N, Vergne C, Leturcq R. Two-Step approach for conformal chemical vapor-phase deposition of ultra-thin conductive silver films. ACS Applied Materials & Interfaces, 2020; 12(32):36329-36338. DOI: https://dx.doi.org/10.1021/acsami.0c08606.
19. Soh SH, Lee LY. Microencapsulation and nanoencapsulation using supercritical fluid (SCF) techniques. Pharmaceutics, 2019; 11(1):21. DOI: https://dx.doi.org/10.3390/pharmaceutics11010021.
20. Trivedi V, Bhomia R, Mitchell JC. Myristic acid coated protein immobilised mesoporous silica particles as ph induced oral delivery system for the delivery of biomolecules. Pharmaceuticals (Basel), 2019; 12(4):153. DOI: https://dx.doi.org/10.3390/ph12040153.
21. Chen LF, Xu PY, Fu CP, Kankala RK, Chen AZ, Wang SB. Fabrication of supercritical antisolvent (SAS) process-assisted Fisetin-encapsulated poly (vinyl pyrrolidone) (PVP) nanocomposites for improved anticancer therapy. Nanomaterials (Basel), 2020; 10(2):322. DOI: https://dx.doi.org/10.3390/nano10020322.
22. Yang Q, Yuan F, Xu L, Yan Q, Yang Y, Wu D, Guo F, Yang G. An update of moisture barrier coating for drug delivery. Pharmaceutics, 2019; 11(9):436. DOI: https://dx.doi.org/10.3390/pharmaceutics11090436.
23. Prasad LK, McGinity JW, Williams RO 3rd. Electrostatic powder coating: Principles and pharmaceutical applications. International Journal of Pharmaceutics, 2016; 505(1-2):289-302. DOI: https://dx.doi.org/10.1016/j.ijpharm.2016.04.016.
24. Bannow J, Koren L, Salar-Behzadi S, Löbmann K, Zimmer A, Rades T. Hot melt coating of amorphous Carvedilol. Pharmaceutics, 2020; 12(6):519. DOI: https://dx.doi.org/10.3390/pharmaceutics12060519.
25. Salar-Behzadi S, Corzo C, Gomes Lopes D, Meindl C, Lochmann D, Reyer S. Novel approach for overcoming the stability challenges of lipid-based excipients. Part 2: Application of polyglycerol esters of fatty acids as hot melt coating excipients. European Journal of Pharmaceutics and Biopharmaceutics, 2020; 148:107-117. DOI: https://dx.doi.org/10.1016/j.ejpb.2020.01.009.
26. Salar-Behzadi S, Corzo C, Schaden L, Laggner P, Zimmer A. Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules. International Journal of Pharmaceutics, 2019; 565:569-578. DOI: https://dx.doi.org/10.1016/j.ijpharm.2019.05.036.
27. Stocker E, Becker K, Hate S, Hohl R, Schiemenz W, Sacher S, Zimmer A, Salar-Behzadi S. Application of ICH Q9 quality risk management tools for advanced development of hot melt coated multiparticulate systems. Journal of Pharmaceutical Sciences, 2017; 106(1):278-290. DOI: https://dx.doi.org/10.1016/j.xphs.2016.09.025.
28. Zier KI, Schultze W, Leopold CS. Combination of a hot-melt subcoating and an enteric coating for moisture protection of hygroscopic Sennae fructus tablets. Pharmaceutical Development and Technology, 2019; 24(10):1210-1217. DOI: https://dx.doi.org/10.1080/10837450.2019.1648509.
29. Wang X, Wang P, Huang C, Lin X, Gong H, He H, Cai C. Hot-melt sub- and outer coating combined with enteric aqueous coating to improve the stability of aspirin tablets. Asian Journal of Pharmaceutical Sciences, 2017; 12(3):266-278. DOI: https://dx.doi.org/10.1016/j.ajps.2016.11.003.
30. Bungert N, Kobler M, Scherließ R. In-depth comparison of dry particle coating processes used in dpi particle engineering. Pharmaceutics, 2021; 13(4):580. DOI: https://dx.doi.org/10.3390/pharmaceutics13040580.
31. Pundir K, Parashar B. The innovations in tablet coating: A review. International Educational Applied Research Journal, 2019; 3(6):18-23.
32. Jeon IS, Lee MH, Choi HH, Lee S, Chon JW, Chung DJ, Park JH, Jho JY. Mechanical properties and bioactivity of Polyetheretherketone/Hydroxyapatite/Carbon fiber composite prepared by the mechanofusion process. Polymers (Basel), 2021; 13(12):1978. DOI: https://dx.doi.org/10.3390/polym13121978.
33. Koskela J, Morton DAV, Stewart PJ, Juppo AM, Lakio S. The effect of mechanical dry coating with magnesium stearate on flowability and compactibility of plastically deforming microcrystalline cellulose powders. International Journal of Pharmaceutics, 2018; 537(1-2):64-72. DOI: https://dx.doi.org/10.1016/j.ijpharm.2017.11.068.
34. Matsumoto A, Ono A, Murao S, Murakami M. Microparticles for sustained release of water-soluble drug based on a containment, dry coating technology. Drug Discoveries & Therapeutics, 2018; 12(6):347-354. DOI: https://dx.doi.org/10.5582/ddt.2018.01082.
35. Qu L, Stewart PJ, Hapgood KP, Lakio S, Morton DAV, Zhou QT. Single-step coprocessing of cohesive powder via mechanical dry coating for direct tablet compression. Journal of Pharmaceutical Sciences, 2017; 106(1):159-167. DOI: https://dx.doi.org/10.1016/j.xphs.2016.07.017.
36. Watano S, Imada Y, Miyanami K, Wu C-Y, Dave RN, Pfeffer R, Yoshida T, Surface modification of food fiber by dry particle coating. Journal of Chemical Engineering of Japan, 2000; 33(6):848-854. DOI: https://dx.doi.org/10.1252/jcej.33.848.
37. Reynolds GK. Modelling of pharmaceutical granule size reduction in a conical screen mill. Chemical Engineering Journal, 2010; 164(2-3):383-392. DOI: https://dx.doi.org/10.1016/j.cej.2010.03.041.
38. Goh WP, Montoya Sanavia A, Ghadiri M. Effect of mixer type on particle coating by magnesium stearate for friction and adhesion modification. Pharmaceutics, 2021; 13:1211. DOI: https://dx.doi.org/10.3390/ 10.3390/pharmaceutics13081211.
39. Ouabbas Y, Dodds J, Galet L, Chamayou A, Baron M. Particle–particle coating in a cyclomix impact mixer. Powder Technology, 2009; 189(2):245-252. DOI: https://dx.doi.org/10.1016/j.powtec.2008.04.031.
40. Serris E, Sato A, Chamayou A, Galet L, Baron M, Grosseau P, Thomas G. Dry coating in a high shear mixer: Comparison of experimental results with DEM analysis of particle motions. AIP Conference Proceedings, 2013; 1542:779. DOI: https://dx.doi.org/10.1063/1.4812047.
41. Galet L, Ouabbas Y, Chamayou A, Grosseau P, Baron M, Thomas G. Surface analysis of silica gel particles after mechanical dry coating with magnesium stearate. Kona Powder and Particle Journal, 2010; 28:209-218. DOI: https://dx.doi.org/10.14356/kona.2010018.
42. Miyazaki Y, Miyawaki K, Uchino T, Kagawa Y. Dry powder coating using planetary centrifugal mixer. Journal of Pharmacy and Pharmaceutical Sciences, 2015; 18(3):460-473.
43. Teng S, Wang P, Zhu L, Young M-W, Gogos CG. Experimental and numerical analysis of a lab-scale fluid energy mill. Powder Technology, 2009; 195(1):31-39. DOI: https://dx.doi.org/10.1016/j.powtec.2009.05.013.
44. Zhang Q, Wang P, Teng S, Qian Z, Zhu L, Gogos CG. Simultaneous milling and coating of inorganic particulates with polymeric coating materials using a fluid energy mill. Polymer Engineering & Science, 2010; 50(12):2366-2374. DOI: https://dx.doi.org/10.1002/pen.21777.
45. Teng S, Wang P, Zhang Q, Gogos C. Analysis of fluid energy mill by gas-solid two-phase flow simulation. Powder Technology, 2011; 208(3):684-693. DOI: https://dx.doi.org/10.1016/j.powtec.2010.12.033.
46. Li M, Zhang L, Davé RN, Bilgili E. An intensified vibratory milling process for enhancing the breakage kinetics during the preparation of drug nanosuspensions. AAPS PharmSciTech, 2016; 17(2):389-99. DOI: https://dx.doi.org/10.1208/s12249-015-0364-3.
47. Tanaka R, Osotprasit S, Peerapattana J, Ashizawa K, Hattori Y, Otsuka M. Complete cocrystal formation during resonant acoustic wet granulation: Effect of granulation liquids. Pharmaceutics. 2021; 13(1):56. DOI: https://dx.doi.org/10.3390/pharmaceutics13010056.
48. Buyukgoz GG, Castro JN, Atalla AE, Pentangelo JG, Tripathi S, Davé RN. Impact of mixing on content uniformity of thin polymer films containing drug micro-doses. Pharmaceutics, 2021; 13(6):812. DOI: https://dx.doi.org/10.3390/pharmaceutics13060812.
49. Zhang L, Alfano J, Race D, Davé RN. Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. European Journal of Pharmaceutical Sciences, 2018; 117:245-254. DOI: https://dx.doi.org/10.1016/j.ejps.2018.02.029.
50. Zhang L, Aloia M, Pielecha-Safira B, Lin H, Rajai PM, Kunnath K, Davé RN. Impact of superdisintegrants and film thickness on disintegration time of strip films loaded with poorly water-soluble drug microparticles. Journal of Pharmaceutical Sciences, 2018; 107(8):2107-2118. DOI: https://dx.doi.org/10.1016/j.xphs.2018.04.006.
51. Jallo LJ, Ghoroi C, Gurumurthy L, Patel U, Davé RN. Improvement of flow and bulk density of pharmaceutical powders using surface modification. International Journal of Pharmaceutics, 2012; 423(2):213-225. DOI: https://dx.doi.org/10.1016/j.ijpharm.2011.12.012.
52. Jallo LJ, Dave RN. Explaining electrostatic charging and flow of surface-modified acetaminophen powders as a function of relative humidity through surface energetics. Journal of Pharmaceutical Sciences, 2015; 104(7):2225-2232. DOI: https://dx.doi.org/10.1002/jps.24479.
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