Research of the Causes and Risk Factors of Autism in the Western Region of Algeria

Authors

  • Hayet Mehida Laboratory of Molecular Microbiology, Proteomics and Health. Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria
  • Samira Meziani Biotoxicology Laboratory. Department of Biology Faculty of Natural and Life Sciences, Djillali Liabes University of Sidibel Abbes, Algeria
  • Wahiba Mehida Department of sociology, Faculty of human sciences, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Khalida Zemri Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria
  • Imene Bekhaled Biotoxicology Laboratory. Department of Biology. Faculty of Natural and Life Sciences. Djilali Liabès University, Sidi-Bel-Abbès. Algeria.
  • Malika Bendahmane Environments and Health Research Laboratory. University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Abstract

Introduction Autism is a neurodevelopmental disorder that manifests before 3 years old and affects many areas, communication, social interactions and behaviors. In Algeria, there has not yet been a regional or national epidemiological investigation concerning autism spectrum disorders.

Materials and methods: Our study was carried about 100 patients ( autistic children) in the western region of Algeria, in order to determine the differents risk factors involved in the onset of autism syndrome.

Results and discussion: The obtained results indicate a male predominance with a sex ratio of 4: 1 and the degree of reached is average in 44% of patients. 42% of the patients are youngsters. Parents' worry about their children begins  between 24 and 36 months. The parents' advanced age at conception, stress, presence of certain pathologies and drug intake by mothers, as well as fetal distress at birth and children's exposure to screens were the main risk factors. Repetitive movements, lack of social communication, language delay, and lack of visual fixation were the main clinical symptomatology.

Conclusion: This study allowed us to detect the main factors associated with the onset of autism. However, the results obtained cannot be generalized to the entire population.

Keywords: Autism, autism spectrum disorder, risk factors, clinical symptoms, western region of Algeria.

Keywords:

Autism, autism spectrum disorder, risk factors, clinical symptoms, western region of Algeria

DOI

https://doi.org/10.22270/jddt.v10i6.4563

Author Biographies

Hayet Mehida, Laboratory of Molecular Microbiology, Proteomics and Health. Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Laboratory of Molecular Microbiology, Proteomics and Health. Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Samira Meziani, Biotoxicology Laboratory. Department of Biology Faculty of Natural and Life Sciences, Djillali Liabes University of Sidibel Abbes, Algeria

Biotoxicology Laboratory. Department of Biology Faculty of Natural and Life Sciences, Djillali Liabes University of Sidibel Abbes, Algeria

Wahiba Mehida, Department of sociology, Faculty of human sciences, Djillali Liabes University of Sidi bel Abbes, Algeria

Department of sociology, Faculty of human sciences, Djillali Liabes University of Sidi bel Abbes, Algeria

Khalida Zemri, Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Department of biology. Faculty of Natural and Life Sciences University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Imene Bekhaled, Biotoxicology Laboratory. Department of Biology. Faculty of Natural and Life Sciences. Djilali Liabès University, Sidi-Bel-Abbès. Algeria.

Biotoxicology Laboratory. Department of Biology Faculty of Natural and Life Sciences, Djillali Liabes University of Sidibel Abbes, Algeria

Malika Bendahmane, Environments and Health Research Laboratory. University Djilali Liabes, Sidi-Bel-Abbes, Algeria

Environment and health research laboratory, faculty of medicine Djillali Liabes University of Sidi bel Abbes, Algeria

References

Werling, D.M., and Geschwind, D.H. Understanding sex bias in autism spectrumdisorder. Proc. Natl. Acad. Sci. U. S. A.; 2013; 110: 4868–4869.

Lord, C., Risi, S., Lambrecht, L., Cook, E.H., Leventhal, B.L., DiLavore, P.C., Pickles, A., et Rutter, M. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism DevDisord 2000; 30:205–223.

Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65:591–8.

Tordjman S, Cohen D, Coulon N. Ed. A, Danion-Grillat, C. Bursztejn, Research in autism. In " Child Psychiatry Lavoisier, 2011 ; p.210-225

Shelton, J.F.Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides : the CHARGE study. Environ Health Perspect,. 2014; 122(10):1103-09.

Rivet, T., and Matson, J. Review of gender differences in core symptomatology in autism spectrum disorders. Res. AutismSpectr. Disord, , 2011; 5:957–976.

United Nations Organizations (2008)., Resolution adopted by the General Assembly, 34/139 World Autism Awareness Day,

Myers, S.M., and Johnson, C.P. Management of children with autism spectrum disorders. Pediatrics 2007; 120:1162–1182.

Grafodatskaya D, Chung B, Szatmari P, et al (2010). Autism spectrum disorders andepigenetics. J Am Acad Child Adolesc Psychiatry; 49:794–809.

Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, et al. (2007)Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet;39:25–7.

Ross, J.L., Roeltgen, D.P., Kushner, H., Zinn, A.R., Reiss, A., Bardsley, M.Z., McCauley, E., and Tartaglia, N. (2012). Behavioral and social phenotypes in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome. Pediatrics129, 769–778.

Roy, M., Dillo, W., Emrich, H.M., and Ohlmeier, M.D. (4009). Asperger’s syndrome in adulthood. Dtsch. Ärztebl. Int. 106, 59–64.

Robins, D L, Fein, D., Barton, M. L., & Green, J. A. (2001). The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders. Journal of autism and developmentaldisorders, 31(2), 131- 144.

Sandin S, D Schendal, P Magnusson, et al (2015). Risk of autism associated with the age of the parents and the increasing age difference between the parents. Molecular Psychiatry.

Sato, D., Lionel, A.C., Leblond, C.S., Prasad, A., Pinto, D., Walker, S., O’Connor, I., Russell, C., Drmic, I.E., Hamdan, F.F., et al. (2012). SHANK1 Deletions in Males with Autism Spectrum Disorder. Am. J. Hum. Genet. 90, 879–887. Glasson et al., 2004;

Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., Cook, E.H., Leventhal, B.L., et Pickles, A. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. J Am Acad Child Adolesc Psychiatry 45, 1094– 1103.

Volkmar FR, Lord C, Bailey A, et al. (2004). Autism and pervasive developmental disorders. J Child Psychol Psychiatry;45(1):135—70. Turner et al., 2011

Pearson, D.A., Santos, C.W., Aman, M.G., Arnold, L.E., Casat, C.D., Mansour, R., Lane, D.M., Loveland, K.A., Bukstein, O.G., Jerger, S.W., et al. (2013). Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. J. Child Adolesc. Psychopharmacol. 23, 337–351.

American Psychiatric Association. (2003). DSM-IV-TR Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised text

Courchesne, E. et Pierce, K. (2005). Brain overgrowth in autism during a critical time in development: Implications for frontal pyramidal neuron and interneuron development and connectivity. International Journal of Developmental Neuroscience, 23, 153–170.

Geier, D.A., Kern, J.K., King, P.G., Sykes, L.K., and Geier, M.R. (2012). An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders. Acta Neurobiol. Exp. (Warsz.) 72, 1–17

Jahromi, L.B., Kasari, C.L., M c Cracken, J.T., Lee, L.S.-Y., Aman, M.G., McDougle, C.J., Scahill, L., Tierney, E., Arnold, L.E., Vitiello, B., et al. (2009). Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity. J. Autism Dev. Disord. 39,395–404. 23 Damkjær Maimburg

Kim, S.H., et Lord, C. (2012). New autism diagnostic interview-revised algorithms for toddlers and young preschoolers from 12 to 47 months of age. J AutismDevDisord42, 82– 93.

McLeod Frampton Gwynette, Shawn S. Sidhu, TolgaAtillaCeranoglu, (2018) Electronic Screen Media Use in Youth With Autism Spectrum Disorder. Child AdolescPsychiatric Clin N Am 27 203–219

Idring S, Lundberg M, Sturm H, Dalman C, Gumpert C, Rai D, Lee BK, Magnusson C. (2014).Changes in Prevalence of Autism Spectrum Disorders in 2001–2011: Findings from the Stockholm Youth Cohort. Journal of autism and developmental disorders, epub ahead of print. PMID: 25475364

Volkmar FR, Lord C, Bailey A, et al. (2004). Autism and pervasive developmental disorders. J Child Psychol Psychiatry;45(1):135-70.

Wolstenholme JT, Edwards M, Shetty SR, et al. (2012)Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology; 153:3828–38

Volk, H.E., et al. (2013). Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry,70(1): p. 71-7.

Shattuck, P. T., Grosse, S., Parish, S., & Bier, D. (2009). Utilization of a Medicaidfunded intervention for children with autism. Psychiatric services (Washington, D.C.), 60(4), 549- 552. doi:10.1176/appi.ps.60.4.549

Wong, L.M., Goodrich-Hunsaker, N.J., McLennan, Y., Tassone, F., Zhang, M., Rivera, S.M., et Simon, T.J. (2014). Eye Movements Reveal Impaired Inhibitory Control in Adult Male Fragile X Premutation Carriers Asymptomatic for FXTAS. Neuropsychology28, 571–584.

Vu, T.H., and Hoffman, A.R. (1997). Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain. Nature Genetics17, 12–13.

State, M.W., and Levitt, P. (2011). The Conundrums of Understanding Genetic Risks for Autism Spectrum Disorders. Nat. Neurosci. 14, 1499–1506.

Richards, C., Jones, C., Groves, L., Moss, J., et Oliver, C. (2015). Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and metaanalysis. Lancet Psychiatry2, 909–916

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., Baird, G., (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 47, 921–929

Sarachana T, Zhou R, Chen G, et al. (2010). Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Med;2:23

Published

15-11-2020
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How to Cite

1.
Mehida H, Meziani S, Mehida W, Zemri K, Bekhaled I, Bendahmane M. Research of the Causes and Risk Factors of Autism in the Western Region of Algeria. J. Drug Delivery Ther. [Internet]. 2020 Nov. 15 [cited 2025 Mar. 24];10(6):91-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4563

How to Cite

1.
Mehida H, Meziani S, Mehida W, Zemri K, Bekhaled I, Bendahmane M. Research of the Causes and Risk Factors of Autism in the Western Region of Algeria. J. Drug Delivery Ther. [Internet]. 2020 Nov. 15 [cited 2025 Mar. 24];10(6):91-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4563

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