Research of the Causes and Risk Factors of Autism in the Western Region of Algeria
Abstract
Introduction Autism is a neurodevelopmental disorder that manifests before 3 years old and affects many areas, communication, social interactions and behaviors. In Algeria, there has not yet been a regional or national epidemiological investigation concerning autism spectrum disorders.
Materials and methods: Our study was carried about 100 patients ( autistic children) in the western region of Algeria, in order to determine the differents risk factors involved in the onset of autism syndrome.
Results and discussion: The obtained results indicate a male predominance with a sex ratio of 4: 1 and the degree of reached is average in 44% of patients. 42% of the patients are youngsters. Parents' worry about their children begins between 24 and 36 months. The parents' advanced age at conception, stress, presence of certain pathologies and drug intake by mothers, as well as fetal distress at birth and children's exposure to screens were the main risk factors. Repetitive movements, lack of social communication, language delay, and lack of visual fixation were the main clinical symptomatology.
Conclusion: This study allowed us to detect the main factors associated with the onset of autism. However, the results obtained cannot be generalized to the entire population.
Keywords: Autism, autism spectrum disorder, risk factors, clinical symptoms, western region of Algeria.
Keywords:
Autism, autism spectrum disorder, risk factors, clinical symptoms, western region of AlgeriaDOI
https://doi.org/10.22270/jddt.v10i6.4563References
Werling, D.M., and Geschwind, D.H. Understanding sex bias in autism spectrumdisorder. Proc. Natl. Acad. Sci. U. S. A.; 2013; 110: 4868–4869.
Lord, C., Risi, S., Lambrecht, L., Cook, E.H., Leventhal, B.L., DiLavore, P.C., Pickles, A., et Rutter, M. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism DevDisord 2000; 30:205–223.
Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65:591–8.
Tordjman S, Cohen D, Coulon N. Ed. A, Danion-Grillat, C. Bursztejn, Research in autism. In " Child Psychiatry Lavoisier, 2011 ; p.210-225
Shelton, J.F.Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides : the CHARGE study. Environ Health Perspect,. 2014; 122(10):1103-09.
Rivet, T., and Matson, J. Review of gender differences in core symptomatology in autism spectrum disorders. Res. AutismSpectr. Disord, , 2011; 5:957–976.
United Nations Organizations (2008)., Resolution adopted by the General Assembly, 34/139 World Autism Awareness Day,
Myers, S.M., and Johnson, C.P. Management of children with autism spectrum disorders. Pediatrics 2007; 120:1162–1182.
Grafodatskaya D, Chung B, Szatmari P, et al (2010). Autism spectrum disorders andepigenetics. J Am Acad Child Adolesc Psychiatry; 49:794–809.
Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, et al. (2007)Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet;39:25–7.
Ross, J.L., Roeltgen, D.P., Kushner, H., Zinn, A.R., Reiss, A., Bardsley, M.Z., McCauley, E., and Tartaglia, N. (2012). Behavioral and social phenotypes in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome. Pediatrics129, 769–778.
Roy, M., Dillo, W., Emrich, H.M., and Ohlmeier, M.D. (4009). Asperger’s syndrome in adulthood. Dtsch. Ärztebl. Int. 106, 59–64.
Robins, D L, Fein, D., Barton, M. L., & Green, J. A. (2001). The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders. Journal of autism and developmentaldisorders, 31(2), 131- 144.
Sandin S, D Schendal, P Magnusson, et al (2015). Risk of autism associated with the age of the parents and the increasing age difference between the parents. Molecular Psychiatry.
Sato, D., Lionel, A.C., Leblond, C.S., Prasad, A., Pinto, D., Walker, S., O’Connor, I., Russell, C., Drmic, I.E., Hamdan, F.F., et al. (2012). SHANK1 Deletions in Males with Autism Spectrum Disorder. Am. J. Hum. Genet. 90, 879–887. Glasson et al., 2004;
Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., Cook, E.H., Leventhal, B.L., et Pickles, A. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. J Am Acad Child Adolesc Psychiatry 45, 1094– 1103.
Volkmar FR, Lord C, Bailey A, et al. (2004). Autism and pervasive developmental disorders. J Child Psychol Psychiatry;45(1):135—70. Turner et al., 2011
Pearson, D.A., Santos, C.W., Aman, M.G., Arnold, L.E., Casat, C.D., Mansour, R., Lane, D.M., Loveland, K.A., Bukstein, O.G., Jerger, S.W., et al. (2013). Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. J. Child Adolesc. Psychopharmacol. 23, 337–351.
American Psychiatric Association. (2003). DSM-IV-TR Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised text
Courchesne, E. et Pierce, K. (2005). Brain overgrowth in autism during a critical time in development: Implications for frontal pyramidal neuron and interneuron development and connectivity. International Journal of Developmental Neuroscience, 23, 153–170.
Geier, D.A., Kern, J.K., King, P.G., Sykes, L.K., and Geier, M.R. (2012). An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders. Acta Neurobiol. Exp. (Warsz.) 72, 1–17
Jahromi, L.B., Kasari, C.L., M c Cracken, J.T., Lee, L.S.-Y., Aman, M.G., McDougle, C.J., Scahill, L., Tierney, E., Arnold, L.E., Vitiello, B., et al. (2009). Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity. J. Autism Dev. Disord. 39,395–404. 23 Damkjær Maimburg
Kim, S.H., et Lord, C. (2012). New autism diagnostic interview-revised algorithms for toddlers and young preschoolers from 12 to 47 months of age. J AutismDevDisord42, 82– 93.
McLeod Frampton Gwynette, Shawn S. Sidhu, TolgaAtillaCeranoglu, (2018) Electronic Screen Media Use in Youth With Autism Spectrum Disorder. Child AdolescPsychiatric Clin N Am 27 203–219
Idring S, Lundberg M, Sturm H, Dalman C, Gumpert C, Rai D, Lee BK, Magnusson C. (2014).Changes in Prevalence of Autism Spectrum Disorders in 2001–2011: Findings from the Stockholm Youth Cohort. Journal of autism and developmental disorders, epub ahead of print. PMID: 25475364
Volkmar FR, Lord C, Bailey A, et al. (2004). Autism and pervasive developmental disorders. J Child Psychol Psychiatry;45(1):135-70.
Wolstenholme JT, Edwards M, Shetty SR, et al. (2012)Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology; 153:3828–38
Volk, H.E., et al. (2013). Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry,70(1): p. 71-7.
Shattuck, P. T., Grosse, S., Parish, S., & Bier, D. (2009). Utilization of a Medicaidfunded intervention for children with autism. Psychiatric services (Washington, D.C.), 60(4), 549- 552. doi:10.1176/appi.ps.60.4.549
Wong, L.M., Goodrich-Hunsaker, N.J., McLennan, Y., Tassone, F., Zhang, M., Rivera, S.M., et Simon, T.J. (2014). Eye Movements Reveal Impaired Inhibitory Control in Adult Male Fragile X Premutation Carriers Asymptomatic for FXTAS. Neuropsychology28, 571–584.
Vu, T.H., and Hoffman, A.R. (1997). Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain. Nature Genetics17, 12–13.
State, M.W., and Levitt, P. (2011). The Conundrums of Understanding Genetic Risks for Autism Spectrum Disorders. Nat. Neurosci. 14, 1499–1506.
Richards, C., Jones, C., Groves, L., Moss, J., et Oliver, C. (2015). Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and metaanalysis. Lancet Psychiatry2, 909–916
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., Baird, G., (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 47, 921–929
Sarachana T, Zhou R, Chen G, et al. (2010). Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Med;2:23
Published


How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).