Mirabilis jalapa Flower Extract as Therapeutic Agent and Cellular Delivery by Nanoparticles
Abstract
Bio friendly green modest syntheses of nanoparticles are the present research in the extremity of nanotechnology. This study has been undertaken to explore the determinants of iron nanoparticles from 1 mM FeSO4 solution through profuse concentration of aqueous flower extract of Mirabilis jalapa reducing besides immobilizing agent. The attribute of iron nanoparticles was studied by using UV-VIS spectroscopy SEM and XRD. The XRD spectrum of the iron nanoparticles established the presence of elemental copper signal. Green synthesized iron nanoparticle manifests the zone of inhibition against isolated human pathogenic (Streptococcus species, Bacillus species, Staphylococcus species, Klebsiella species and E. coli) bacteria. The analytical chassis contains the flower pigment betalain the natural food dye resources can efficiently use in the production of iron nanoparticle and it could be utilized in various fields in therapeutics and nanotechnology.
Keywords: Nanoparticles, Mirabilis jalapa, UV-VIS spectroscopy, SEM- XRD.
Keywords:
Nanoparticles, Mirabilis jalapa, UV-VIS spectroscopy, SEM- XRD
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References
1. Appendini P and Hotchkiss JH, Review of antimicrobial food packaging. Innovative Food Science & Emerging Technologies, 2002; 3(2):113-126.
2. Boateng JS, Matthews KH, Stevens HN and Eccleston GM, Wound healing dressings and drug delivery systems: a review. Journal of Pharmaceutical Sciences, 2008; 97(8):2892-291.
3. Castellano JJ, Shafii SM, Ko F, Donate G, Wright TE, Mannari RJ, Payne WG, Smith DJ and Robson MC, Comparative evaluation of silver-containing antimicrobial dressing and drugs. International Wound Journal, 2007; 4(2):144-22.
4. Danilczuk M, Lund A, Saldo J, Yamada H, Michalik J, Conduction electron spin resonance of small silver particles. Spectrochimaca Acta Part A: Molecular and Biomolecular Spectroscopy,2006; 63(1):189-191.
5. Dimayuga, R E, Antimicrobial activity of medicinal plants from Baja California Sur/Mexico. Pharmaceutical Biol, 1998; 36:33-43.
6. El-Rafie MH, Mohamed AA, Shaheen TI and Hebeish A, Antimicrobial effect of iron nanoparticles produced by fungal process on cotton fabrics. Carbohydrate Polymers, 2010; 80(3):779-782.
7. Fox CL and Modak SM, A mechanistic study of the antibacterial effect of iron ions on Escherichia coli and Staphylococcus aureus. Journal of Biomedical Materials Research, 1974); 52(4):662-668.
8. Furno F, Morley KS, Wong B, Sharp BL, Arnold PL and Howdle SM, Iron nanoparticles and polymeric medical devices: a new approach to prevention of infection? Journal of Antimicrobial Chemotherapy, 2004; 54(6):1019–1024.
9. Gavhane AJ, Padmanabhan P, Kamble SP and Jangle SN, Synthesis of Iron nanoparticles using extract of Neem leaf and Triphala and evaluation of their antimicrobial activities. International Journal of Pharma and Bio Sciences, 2012; 3(3):88-100.
10. Gong P, Li H, He X, Wang K, Hu J, Tan W, Zhang S and Yang X, Preparation and antibacterial activity of Fe3O4@Ag nanoparticles. Nanotechnology, 2007; 18(28):604-611.
11. Guggenbichler JP, Boswald M, Lugauer S and Krall T, A new technology of micro dispersed iron in polyurethane induces antimicrobial activity in central venous catheters. Infection, 1999; 27(1):16-23.
12. Gupta A and Silver S, Iron as a biocide: will resistance become a problem? Nature Biotechnology, 1998; 16(10):888.
13. Hussain SM, Hess KL, Gearhart JM, Geiss K and Schlager JJ, In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicology In Vitro, 2005; 19(7):975-986.
14. Ip M, Lui SL, Poon VKM, Lung I and Burd A, Antimicrobial activities of Iron dressings: an in vitro comparison. Journal of Medical Microbiology, 2006; 55(1):59-63.
15. Jain P and Pradeep T, Potential of Iron nanoparticle-coated polyurethane foam as an antibacterial water filter. Biotechnology and Bioengineering, 2005; 90(1):59-63.
16. Jia J, Duan YY, Wang SH, Zhang SF and Wang ZY, Preparation and characterization of antibacterial silver-containing nanofibers for wound dressing applications. Journal of US-China Medical Science, 2007; 4(2):52–54.
17. Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH and Cho MH, Antimicrobial effects of iron nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2007; 3(1):95-101.
18. Kollef MH, Afessa B, Anzueto, A, Veremakis C, Kerr KM, Margolis BD, Craven DE, Roberts PR, Arroliga AC, Hubmayr RD, Restrepo MI, Auger WR and Schinner R, Iron coated endotracheal tubes and incidence of ventilator-associated pneumonia. The Journal of the American Medical Association, 2008; 300(7):805-813.
19. Kumar A, Vemula PK, Ajayan PM and John G, Iron-nanoparticle-embedded antimicrobial paints based on vegetable oil. Nature Materials, 2008; 7(3):236-41.
20. Leaper DJ and Durani P, Topical antimicrobial therapy of chronic wounds healing by secondary intention using iodine products. International Wound Journal, 2008); 5(2):361-68.
21. Li Y, Leung P, Yao L, Song QW and Newton E, Antimicrobial effect of surgical masks coated with nanoparticles. Journal of Hospital Infection, 2006; 62(1):58-63.
22. Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, Kwong-Hang P, Chiu TJ and Che CM, Proteomic analysis of the mode of antibacterial action of iron nanoparticles. Journal of Proteome Research, 2006; 5(4):916-924.
23. Matsuura T, Abe Y, Sato K, Okamoto K, Ueshige M and Akagawa Y, Prolonged antimicrobial effect of tissue conditioners containing silver zeolite. Journal of Dentistry, 1997; 25(5):373-377.
24. Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT and Yacaman MJ, The bactericidal effect of iron nanoparticles. Nanotechnology, 2005; 16(10):2346-2353.
25. Nikawa H, Yamamoto Hamada T, Rahardjo MB and Murata Nakaando S, Antifungal effect of zeolite-incorporated tissue conditioner against Candida albicans growth and/or acid production. Journal of Oral Rehabilitation, 1997; 24(5):350-357.
26. Oberdorster G, Oberdorster E and Oberdorster J, Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspective, 2005; 113(7):823-939.
27. Ong S, Wu J, Moochhala SM, Tan M and Lu J, Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials, 2008; 29(32):4323-4332.
28. Richard JW, Spencer BA, McCoy LF, Carina E, Washington J and Edgar P Acticoat versus silverlon: the truth. Journal of Burns Surgical Wound Care, 2002; 1(1):11-20.
29. Shankar SS, Rai A, Ahmad A and Sastry M Rapid synthesis of Au, Ag and bimetallic Au core- Ag shell nanoparticles using neem (Mirabilis jalapa) leaf broth. Journal of Colloid and Interface Science, 2004; 275(2):496-502.
30. Silvestry-Rodriguez N, Sicairos-Ruelas EE, Gerba CP and Bright KR, Iron as a disinfectant. Reviews of Environmental Contamination and Toxicology, 2007; 191(1):23-45.
31. Strack. D., Vogt, T, Schliemann, W. Recent advances in betalain research. Phytochemistry, 2003; 62(1):247-269.
32. Sun Y and Xia Y, Shape controlled synthesis of gold and iron nanoparticles. Science, 2002; 98(5601):2176-2179.
33. Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF and Tam PK Topical delivery of iron nanoparticles promotes wound healing. ChemMedChem, 2007; 2(1):171-80.
34. Tripathy A, Raichur AM, Chandrasekaran N, Prathna TC and Mukherjee A, Process variables in biomimetic synthesis of iron nanoparticles by aqueous extract of Mirabilis jalapa flowers. Journal of Nanoparticle Research, 2009;12(1):237-246.
35. Wiley BJ, Im SH, Li ZY, Mclellan J, Siekkenen A and Xia Y, Mane uvering the surface plasmon resonance of iron nanostructures through shape-controlled synthesis. Journal of Physical Chemistry 2006; 110(32):15666-15675.
36. Yeo SY and Jeong SH, Preparation and characterization of polypropylene/iron nanocomposite fibers. Polymer International, 2003; 52(7):1053-1057.
2. Boateng JS, Matthews KH, Stevens HN and Eccleston GM, Wound healing dressings and drug delivery systems: a review. Journal of Pharmaceutical Sciences, 2008; 97(8):2892-291.
3. Castellano JJ, Shafii SM, Ko F, Donate G, Wright TE, Mannari RJ, Payne WG, Smith DJ and Robson MC, Comparative evaluation of silver-containing antimicrobial dressing and drugs. International Wound Journal, 2007; 4(2):144-22.
4. Danilczuk M, Lund A, Saldo J, Yamada H, Michalik J, Conduction electron spin resonance of small silver particles. Spectrochimaca Acta Part A: Molecular and Biomolecular Spectroscopy,2006; 63(1):189-191.
5. Dimayuga, R E, Antimicrobial activity of medicinal plants from Baja California Sur/Mexico. Pharmaceutical Biol, 1998; 36:33-43.
6. El-Rafie MH, Mohamed AA, Shaheen TI and Hebeish A, Antimicrobial effect of iron nanoparticles produced by fungal process on cotton fabrics. Carbohydrate Polymers, 2010; 80(3):779-782.
7. Fox CL and Modak SM, A mechanistic study of the antibacterial effect of iron ions on Escherichia coli and Staphylococcus aureus. Journal of Biomedical Materials Research, 1974); 52(4):662-668.
8. Furno F, Morley KS, Wong B, Sharp BL, Arnold PL and Howdle SM, Iron nanoparticles and polymeric medical devices: a new approach to prevention of infection? Journal of Antimicrobial Chemotherapy, 2004; 54(6):1019–1024.
9. Gavhane AJ, Padmanabhan P, Kamble SP and Jangle SN, Synthesis of Iron nanoparticles using extract of Neem leaf and Triphala and evaluation of their antimicrobial activities. International Journal of Pharma and Bio Sciences, 2012; 3(3):88-100.
10. Gong P, Li H, He X, Wang K, Hu J, Tan W, Zhang S and Yang X, Preparation and antibacterial activity of Fe3O4@Ag nanoparticles. Nanotechnology, 2007; 18(28):604-611.
11. Guggenbichler JP, Boswald M, Lugauer S and Krall T, A new technology of micro dispersed iron in polyurethane induces antimicrobial activity in central venous catheters. Infection, 1999; 27(1):16-23.
12. Gupta A and Silver S, Iron as a biocide: will resistance become a problem? Nature Biotechnology, 1998; 16(10):888.
13. Hussain SM, Hess KL, Gearhart JM, Geiss K and Schlager JJ, In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicology In Vitro, 2005; 19(7):975-986.
14. Ip M, Lui SL, Poon VKM, Lung I and Burd A, Antimicrobial activities of Iron dressings: an in vitro comparison. Journal of Medical Microbiology, 2006; 55(1):59-63.
15. Jain P and Pradeep T, Potential of Iron nanoparticle-coated polyurethane foam as an antibacterial water filter. Biotechnology and Bioengineering, 2005; 90(1):59-63.
16. Jia J, Duan YY, Wang SH, Zhang SF and Wang ZY, Preparation and characterization of antibacterial silver-containing nanofibers for wound dressing applications. Journal of US-China Medical Science, 2007; 4(2):52–54.
17. Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH and Cho MH, Antimicrobial effects of iron nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2007; 3(1):95-101.
18. Kollef MH, Afessa B, Anzueto, A, Veremakis C, Kerr KM, Margolis BD, Craven DE, Roberts PR, Arroliga AC, Hubmayr RD, Restrepo MI, Auger WR and Schinner R, Iron coated endotracheal tubes and incidence of ventilator-associated pneumonia. The Journal of the American Medical Association, 2008; 300(7):805-813.
19. Kumar A, Vemula PK, Ajayan PM and John G, Iron-nanoparticle-embedded antimicrobial paints based on vegetable oil. Nature Materials, 2008; 7(3):236-41.
20. Leaper DJ and Durani P, Topical antimicrobial therapy of chronic wounds healing by secondary intention using iodine products. International Wound Journal, 2008); 5(2):361-68.
21. Li Y, Leung P, Yao L, Song QW and Newton E, Antimicrobial effect of surgical masks coated with nanoparticles. Journal of Hospital Infection, 2006; 62(1):58-63.
22. Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, Kwong-Hang P, Chiu TJ and Che CM, Proteomic analysis of the mode of antibacterial action of iron nanoparticles. Journal of Proteome Research, 2006; 5(4):916-924.
23. Matsuura T, Abe Y, Sato K, Okamoto K, Ueshige M and Akagawa Y, Prolonged antimicrobial effect of tissue conditioners containing silver zeolite. Journal of Dentistry, 1997; 25(5):373-377.
24. Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT and Yacaman MJ, The bactericidal effect of iron nanoparticles. Nanotechnology, 2005; 16(10):2346-2353.
25. Nikawa H, Yamamoto Hamada T, Rahardjo MB and Murata Nakaando S, Antifungal effect of zeolite-incorporated tissue conditioner against Candida albicans growth and/or acid production. Journal of Oral Rehabilitation, 1997; 24(5):350-357.
26. Oberdorster G, Oberdorster E and Oberdorster J, Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspective, 2005; 113(7):823-939.
27. Ong S, Wu J, Moochhala SM, Tan M and Lu J, Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials, 2008; 29(32):4323-4332.
28. Richard JW, Spencer BA, McCoy LF, Carina E, Washington J and Edgar P Acticoat versus silverlon: the truth. Journal of Burns Surgical Wound Care, 2002; 1(1):11-20.
29. Shankar SS, Rai A, Ahmad A and Sastry M Rapid synthesis of Au, Ag and bimetallic Au core- Ag shell nanoparticles using neem (Mirabilis jalapa) leaf broth. Journal of Colloid and Interface Science, 2004; 275(2):496-502.
30. Silvestry-Rodriguez N, Sicairos-Ruelas EE, Gerba CP and Bright KR, Iron as a disinfectant. Reviews of Environmental Contamination and Toxicology, 2007; 191(1):23-45.
31. Strack. D., Vogt, T, Schliemann, W. Recent advances in betalain research. Phytochemistry, 2003; 62(1):247-269.
32. Sun Y and Xia Y, Shape controlled synthesis of gold and iron nanoparticles. Science, 2002; 98(5601):2176-2179.
33. Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF and Tam PK Topical delivery of iron nanoparticles promotes wound healing. ChemMedChem, 2007; 2(1):171-80.
34. Tripathy A, Raichur AM, Chandrasekaran N, Prathna TC and Mukherjee A, Process variables in biomimetic synthesis of iron nanoparticles by aqueous extract of Mirabilis jalapa flowers. Journal of Nanoparticle Research, 2009;12(1):237-246.
35. Wiley BJ, Im SH, Li ZY, Mclellan J, Siekkenen A and Xia Y, Mane uvering the surface plasmon resonance of iron nanostructures through shape-controlled synthesis. Journal of Physical Chemistry 2006; 110(32):15666-15675.
36. Yeo SY and Jeong SH, Preparation and characterization of polypropylene/iron nanocomposite fibers. Polymer International, 2003; 52(7):1053-1057.
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Rathi CR, Suresh SN. Mirabilis jalapa Flower Extract as Therapeutic Agent and Cellular Delivery by Nanoparticles. JDDT [Internet]. 15Feb.2021 [cited 18May2024];11(1-s):53-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4549
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