TNF-α: A Benificial or Harmful Pathogenic Cytokine in Cardiovascular System

  • Sunny Dhiman School of Pharmacy Abhilashi University Mandi H.P India
  • Inder Kumar School of Pharmacy Abhilashi University Mandi H.P India
  • Priyankul Palia School of Pharmacy Abhilashi University Mandi H.P India
  • Shalini Jamwal School of Pharmacy Abhilashi University Mandi H.P India
  • Pankaj Kumar School of Pharmacy Abhilashi University Mandi H.P India


Tumor necrosis factor (TNF- alpha) plays important role in pathophysiology of cardiovascular system and had been comprehensively studied over the last 20 years.  These studies demonstrate both Detrimental and potentially conflicting roles of TNF-α in pathophysiology of heart. Beneficial effects of TNF-α includes cardioprotective action against ischemia, myocarditis, pressure overload and preventive action against potential adverse effects including development of atherosclerosis, reperfusion injury, hypertrophy, and heart failure. However, TNF-α is still controversial for its beneficial or harmful effects for cardiovascular system. This review includes evaluation of possible role of TNF-α in cardiovascular system specifically in pathophysiology and morphology of cardiomyocytes. Further this article mainly emphases on the claimed role of TNF-α pathways with concerning essential cardiac cellular processes which may have unswerving adaptive effects in the heart with respect to future research directions. 

Keywords: Tumor Necrosis Factor, Hypertrophy, Pathophysiology, Cytokine, Pathology, Cardiovascular System.

Keywords: Tumor Necrosis Factor, Hypertrophy, Pathophysiology, Cytokine, Pathology, Cardiovascular System


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Author Biographies

Sunny Dhiman, School of Pharmacy Abhilashi University Mandi H.P India

School of Pharmacy Abhilashi University Mandi H.P India

Inder Kumar, School of Pharmacy Abhilashi University Mandi H.P India

School of Pharmacy Abhilashi University Mandi H.P India

Priyankul Palia, School of Pharmacy Abhilashi University Mandi H.P India

School of Pharmacy Abhilashi University Mandi H.P India

Shalini Jamwal, School of Pharmacy Abhilashi University Mandi H.P India

School of Pharmacy Abhilashi University Mandi H.P India

Pankaj Kumar, School of Pharmacy Abhilashi University Mandi H.P India

School of Pharmacy Abhilashi University Mandi H.P India


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Dhiman S, Kumar I, Palia P, Jamwal S, Kumar P. TNF-α: A Benificial or Harmful Pathogenic Cytokine in Cardiovascular System. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):114-20. Available from: