Formulation and Evaluation of Fusidic Acid Emulgel
Abstract
Emulgel have emerged as one of the most interesting topical delivery system as it has dual control release system i.e gel and emulsion. Topical applications of drug offers many advantages for delivering drug directly to the site of action and deliver the drug for extended period of time at effected site. The major objective behind this formulation is to enhance topical delivery of hydrophobic drug (Fusidic acid) by formulating Fusidic acid emulgel by using carbopol 934 as gelling agent. In addition light liquid paraffin as oil, span 20 as emulsifier and propylene glycol as co-surfactant were selected for the preparation of emulgel. Fusidic acid is steroidal bacteriostatic agent produced from Fusidium coccineum fungus belongs to class of steroids but has no corticosteroids effect and which is useful for the treatment of number of infections. Fusidic acid binds to protein and ribosomes and inhibits bacterial protein synthesis. The prepared emulgel were evaluated for their physical appearance, pH determination, viscosity, spreadability, in-vitro drug release, antimicrobial activity, skin irritation study and stability. All the prepared emulgel showed acceptable physical properties. The best formulation E9 shows better drug release when compared to all formulation.
Keywords: Emulgel, Carbopol 934, Topical formulation, Antimicrobial activity, optimization, Fusidic acid
Keywords:
Emulgel, Carbopol 934, Topical formulation, Antimicrobial activity, optimization, Fusidic acidDOI
https://doi.org/10.22270/jddt.v10i3-s.4119References
Single V, Saini S, Joshi B, Rana AC, “Emulgel: A new platform for topical drug delivery” International Journal of Pharma and Bio Sciences, 2012; 3(1):485-498.
Panwar AS, Upadhyay N, Bairagi M, Gujar S, Darwhekar GN, Jain DK, “Emulgel: A Review” Asian Journal of Pharmacy and Life Science, 2011; 1(3):333-343.
Kuller R, Saini S, Seth N, Rana AC, “Emulgel: A surrogate approach for topical used hydrophobic drugs” International Journal of Pharmaceutical Bio Science, 2011; 1(3):117-128.
Jain A, Gautam SP, Gupta, Jain S, “Development and characterization of ketoconazole emulgel for topical drug delivery” Der Pharmacia Sinica, 2010; 1(3):221-231.
Mohamed MI, “Optimization of chlorphenesin emulgel formulation” The AAPS Journal, 2004; 6(3):1-7.
Djordjevic J, Michniak B, Uhrich, Kathryn E, “AAPS Pharm Sci Tech, 2003; 5(4):1-12.
Buket NA, Yozgatl V, Okur ME, Aylad S, Yoltase A, Okur NU, “Preparation and evaluation of QbD based Fusidic acid loaded in situ gel formulation for burn wound treatment” Journal of Drug Delivery Science and Technology, 2019; 52:110-121.
Dobie D, Gray J, “Fusidic acid resistance in staphylococcus aureus” Arch Dis Child, 2004; 89:74-77.
Sanjay, Jain BD, Padsalg A, Patel K, Mokale V, “Formulation, development and evaluation of fluconazole gel in various polymer bases” Asian Journal of Pharmacy, 2007; 1:63-68.
Dev A, Chodankar R, Shelke O, “Emulgels: A novel topical drug delivery system” Pharmaceutical and biological evaluations, 2015; 2(4):64-75.
Kumar D, Singh J, Antil M, Kumar V, “Emulgel- Novel topical drug delivery system- A comprehensive review” International Journal of Pharmaceutical Sciences and Research, 2016; 7(12):4733-4742.
Navaneetha K, Asma B, Sumalatha P, Vinita D, Sravan J, Chinnala MK, “Formulation and in-vitro evaluation of capsaicin emulgel for topical delivery” Scholars Academic Journal of Pharmacy, 2017; 6(6):281-287.
OECD Guideline for testing of chemical 404 on acute dermal irritation/corrosion adopted at 28 july 2015.
Ranga PM, Sella KV, Natarajan R, Kumar MK, “Formulation and in-vitro evalution of ciprofloxacin loaded topical emulgel” International Journal of Pharmaceutical and Chemical Sciences, 2012; 1(1):237-242.
Mohite SV, Salunkhe AK, Sudke SG, “Emulgel: A novel approach for hydrophobic drugs” American Journal of Pharmtech Research, 2019; 9(2):209-224.
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