Polyphenolic content, Antioxidant and Anti-inflammatory activities of Melon (Cucumis melo L. var. inodorus) Seeds

Authors

  • Amel Bouaziz Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria
  • Saliha Djidel Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria
  • Assia Bentaher Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria
  • Seddik Khennouf Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Abstract

The aim of this study was to estimate the content of polyphenols, flavonoids and tannins compounds and to evaluate the antioxidant activity and  the  in vitro anti-inflammatory  of    the ethanolic extract of  melon (Cucumis melo L.  var inodorus) seeds. The Folin-Ciocalteau and AlCl3 methods were applied in order to quantify the polyphenolic and flavonoids contents, respectively. However, DPPH and  β-carotene bleaching  method were applied  to evaluate the  in vitro antioxidant activity. The polyphenolic  and flavonoids contents  of    seeds  extract  were  found to be 37,10 ± 1,11 mg GAE/g of dry extract and 0,43 ± 0,27 mg QE/ g  of dry extract, respectively. Whereas the amount of tannins was  48, 30 ±  0,90 mg TAE/ g of dry extract. The scavenger effect of  seeds extract against DPPH radicals showed IC50 value of  4,13 ± 0,07 mg/ ml. The β-carotene bleaching assay indicated a strong inhibition percentage of the lipid peroxidation with value of 69,47 %. The in vitro anti-inflammatory activity was evaluated using the inhibition of   proteins denaturation revealed that the seeds extract had a moderate anti-inflammatory activity which is estimated at 49,09 % compared to the aspirin (97,73  %) at 1 mg/ ml.  Finally, melon seeds may be considered as a promising source of natural antioxidants which possess remarkable therapeutic action as inflammatory activity and may serve as food ingredients.

Keywords: Cucumis melo var. inodorus, Polyphenols, Flavonoids, Tannins, Oxidative stress,  Anti-inflammatory activity.

Keywords:

Cucumis melo var. inodorus, Polyphenols, Flavonoids, Tannins, Oxidative stress, Anti-inflammatory activity

DOI

https://doi.org/10.22270/jddt.v10i2-s.4022

Author Biographies

Amel Bouaziz, Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of  Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Saliha Djidel, Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of  Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Assia Bentaher, Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of  Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Seddik Khennouf, Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of  Nature and Life Sciences, University Ferhat Abbas Setif 1, 19000, Algeria

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Published

15-04-2020
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How to Cite

1.
Bouaziz A, Djidel S, Bentaher A, Khennouf S. Polyphenolic content, Antioxidant and Anti-inflammatory activities of Melon (Cucumis melo L. var. inodorus) Seeds. J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):22-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4022

How to Cite

1.
Bouaziz A, Djidel S, Bentaher A, Khennouf S. Polyphenolic content, Antioxidant and Anti-inflammatory activities of Melon (Cucumis melo L. var. inodorus) Seeds. J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):22-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4022

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