Evaluation of Antidiabetic and Antihyperlipidemic Effect of Ethanolic Leaves Extract of Centratherum anthelminticum (L) Kuntze against STZ Induced Diabetic Rats
Abstract
Objective: To evaluate the Antidiabetic & Antihyperlipidemic effect of Centratherum Anthelminticum (L) Kuntze extract against STZ induced diabetic rats.
Methods: The present study examined the influence of Centratherum Anthelminticum extract (CASE), on blood glucose level and antioxidant enzymes level in STZ induced diabetic rats. The possible effects of chronic administration of the extract on the fasting serum glucose, insulin, and total cholesterol and triglycerides levels in STZ-induced diabetic rats were also evaluated.
Results: The extracts showed a marked Antidiabetic & Antihyperlipidemic effect. Centratherum anthelminticum ethanolic seeds extract is capable of exhibiting glycemic control through its inhibitory effect on glycogenolytic enzyme glycogen phosphorylase, gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bis phosphatase and stimulatory effect on hexokinase, which is the key enzyme in the glycolytic pathway.
Antihyperlipidemic activity of Centratherum anthelminticum ethanolic seeds extract proved by restoration of altered lipid profile
Conclusions: The results of the study indicate that the extract of Centratherum anthelminticum possesses strong antidiabetic & antihyperlipidemic activity. This study also describes therapeutic effect of Centratherum anthelminticum in diabetes which will give a new direction for the future scientific research.
Keywords: Diabetes, Centratherum anthelminticum, Pharmacological, Antidiabetic, Antihyperlipidemic
Keywords:
Diabetes, Centratherum anthelminticum, Pharmacological, Antidiabetic, AntihyperlipidemicDOI
https://doi.org/10.22270/jddt.v10i2-s.4014References
Badarinath AV, Rao KM, Chetty CMS, Ramkanth V, A review on in-vitro antioxidant methods: comparisons, correlations and considerations. Int. J. PharmTech Res, 2010; 2, 1276–1285.
Baker H, Frank O, De Angeles , Feinglod S, Plasma α-tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutrition Reports International, 1980; 21, 531-534.
Banerjee S K, Bonde CG. Total phenolic content and antioxidant activity of extracts of Bridelia retusa Spring Bark: Impact of dielectric constant and geographical location. J Med Plants Res, 2011; 5, 817-822.
Blokhina O, Virolainen E, Fagersted KV.Antioxidants, oxidative damage and oxygen deprivation stress: a review. Annals Bot 2003; 91, 2, 179-94.
Chakravarthy BK, Gupta S, Gambhir SS, Grode KD, Pancreatic beta cell regeneration. A novel anti-diadetic mechanism of Pterocarpus marsupium Rob. Indian journal of pharmacology, 1980; 12, 123-127.
Chance B, Grenstein DS, Roughton RJ, The mechanism of catalase action 1- steady state analysis. Arch Biochem Biophy, 1952; 301-339.
Chaouki S, Houria M, Mohammed El Amine Dib., Meriem Z, Boufeldja T, Anti-diabetic activity of aqueous root extract of Anacyclus pyrethrum L. in streptozotocin-induced diabetic rats. Journal of Medicinal Plants Research, 2012; 6, 16, 3193-3198.
Dorman HJD, Peltoketo A, Hiltunen R, Tikkane MJ, Characterisation of the antioxidant properties of deodourisation aqueous extracts from selected Lamiaceae Herbs. Food Chem, 2003; 83, 255-256.
Dukes, Phytochemical and Ethnobotanical Databases Phytochemical and Ethnobotanical Databases, 2003; www.ars-gov/cgi-bin/duke/.
Duh PD, Tu YY, Yen GC, Antioxidant activity of water extract of Harng Jyur. (Chyrsanthemum morifolium Ramat). LWT-Food Sci. Technol, 1999; 32, 269-277.
Duraipandiyan V, Al-Dhab NA, Irudayaraj SS, Christudas S, Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats. Revista Brasileira de Farmacognosia, 2016; 26, 89–93.
Abate N, Chandalia M, The impact of ethnicity on type 2 diabetes. Journal of diabetes and its Complications, 2003; 17, 39–58.
Abdallah IZ, Evaluation of Hypoglycemic Activity of Opuntia dillenii Haw Fruit Juice in Streptozotocin-Induced diabetic rats. The Egyptian Journal of Hospital Medicine, 2008; 33, 544–558.
Abdul J, Hussain AZ, Water Quality Index of Uyyakondan Channel of River Cauvery at Tiruchirappalli. IJEP,2005; 25, 10, 941 – 942.
Mannan A, Beauty AR, A Quick Review on Anti-diabetic Plants and Action of Phytochemicals. International Journal of Advanced Research, 2004;2, 5, 227-249.
Abdul Z, AO Salim, Assaf MH, Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J.Ethnopharmacol, 2005; 3, 101(1-3), 129-38.
Al-Sharmony L, Al-Khazraji SM, Twaji HA, Hypoglycemic effect of Artemisia herb alba II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethno Pharamacol, 1994; 43, 167-171.
Anandi C, Alaguraja D, Natarajan V, Ramanathan M, Subramaniam C S, Thulasiram, M. Bacteriology of diabetic foot lesions. Indian J Med Microbiology, 2004; 22,175-8.
Ananthan R, Latha M, Ramkumar KM, Pari L, Basker L, Narmatha Bai V. Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes. Nutrition, 2004; 6, 379 – 386.
Arathi G, Sachdanandam, Therapeutic effect of Semecarpus and Cardium Linn, nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats, J. Pharm and Pharmol,2003; 55, 1283-1290.
Arthika S, Shanthammal Y, Sheryl IN, Hepatoprotective Activity of the Ethanoilc Extract of Azima tetracantha against Paracetamol-Induced Hepatotoxicity in Wistar Albino Rats. Journal of Advances in Pharmacy and Healthcare Research, 2011;1, 2, 14-21.
Arumugam S, Gopal M, Gopalakrishnan S, Ravikanth P, Prakasam G, Anand M, Screening of antibacterial properties of Indian medicinal plants against multi drug resistant diabetic foot ulcer isolates. International Journal of Phytopharmacology, 2012; 3, 2, 139-146.
Atmani D, Chaher N, Berboucha M, Ayouni K, Lounis H, Boudaoud H, Debbache N, Atmani D. Antioxidant capacity and phenol content of selected Algerian medicinal plants. Food Chem, 2009; 112, 303-30.
Awoyinka OA, Balogun IO, Ogunnow AA. Phtochemical screening and in vitro bioactivity of Cnidoscolus aconitifolius (Euphorbiaceae). J. Med. Plant Res,2007; 1, 63-95.
Blytt HJ, Guscar TK, Butler LG, Antinutritional effects and ecological significance of dietary condensed tannins may not be due to binding and inhibiting digestive enzymes. Journal of Chemical Ecology, 1988; 14, 1455-1465.
Bolaffi JL, Nagamatsu S, Harris J, Grodsky GM, Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion. Endocrinology, 1987; 120, 2117-2122.
Bonting SL, Bilter EE, Membrane and ion transport, London Wiley Interscience, 1970;257.
Bopana KN, Kannan J, Sushma gangil, Blaraman R, Rathod SP, Antidiabetic and anti hyperlipedemic effect of Neem, Lipedemic effect of Neem seed kernel powder on alloxon diabetic rabbits. Ind. J. Pharmacology, 1977; 29, 162-167.
Bora KS, Sharma A. In-Vitro Antioxidant and Free Radical Scavenging Potential of Medicago sativa Linn. J. Pharma. Res, 2011; 3, 1206‐1210.
Brahmachari G. Six Bio-flavonoids with promising antidiabetic potentials: a critical survey, in Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry, 2011; 187–212.
Brandstrup N, Kirk JE, Brunic, The hexokinase method and phosphoglucoisomerase activities and aortic pulmonary artery in individuals of various ages, J Gerontol, 1957;12, 166.
Brownlee M, Cerami A, Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med, 1981; 318, 1315–1321.
Bruce A, Freeman D, James C, Biology of disease-free radicals and tissue injury. Lab Invest, 1982; 47, 412–26.
Caraway WT, Determination of uric acid in serum by carbonate method. Am J Clin Path, 1955; 25, 840-845.
Caroll NV, Longly RW, Roe JH, The determination of glycogen in liver and muscle by use of anthrone reagent, J. Biol Chem., 1956;220, 58.
CDER. (1994). Reviewer Guidance: Validation of Chromatographic Methods. FDA. CDER. (2004). Guidance for Industry Analytical Procedures and Methods Validation. FDA.
Chakrabarti R, Rajagopalan R, Diabetes and insulin resistance associated disorders. disease and the therapy. Current Science, 2002; 83, 12, 1533-8.
Chelladurai V, Millikizhangu- an unique folk medicinal plant from the adivasis (tribals) of point calimare, Tamilnadu. Bull Med Ethno Bot Res, 1983; 4, 4148-153.
Chen KK, Robert CA, McCowen MC, Harris PN, Pharmacological action of hypoglycin A & B. The J Phar Exp Pharmacol, 1957; 121, 272-285.
Cheng AY, Fantus IG, Oral antihyperglycemic therapy for type 2 diabetes Mellitus Can. Med. Assoc. J, 2005;17, 2, 213-26.
Pulok KM, Kuntal M, Kakali M, Peter JH, Leads from Indian medicinal plants with hypoglycemic potentials. Journal of ethnopharmacology, 2007; 106, 1–28.
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