EFFECT OF DURUM WHEAT BRAN ON GLUCOSE AND LIPID METABOLISM IN DIABETIC RATS.
Abstract
Introduction: Durum wheat bran is obtained from wheat milling, it’s considered as an excellent source of insoluble dietary fibre. Objective. The aim of this paper was to evaluate the effect of wheat bran (WB) on glucose and lipid metabolism in normal and diabetic rats. Materials and Methods. Twenty-four female rats of "Wistar" were divided into four groups each containing six rats. The first group (NCR) was fed by a control diet while the second group (NCRE) was fed by the experimental diet based on durum wheat bran. For the third and fourth group after streptozotocin (STZ) injection, they were fed by a control diet (DCR) and experimental diet (DRE) respectively. The Blood Glucose (g/L) and weight (g) of these groups was measured at the end of each week for a period of four weeks, the serum lipid parameters in the fasting condition, such as TC, TG, LDL-C and HDL-C were evaluated at the end of the experience. Results. WB was high in dietary fibre (41%). The results show a significant decrease in blood glucose ( p<0.04) and body weight ( p<0.05 ) in DRE group compared to DCR group and non-diabetic groups. No significant difference was observed for cholesterol and triglyceride levels, a difference of p<0.05 for HDL-C was observed between the diabetic experimental diet group and the non-diabetic control diet group. For LDL-C, the difference was observed between the diabetic experimental group and the non-diabetic experimental group (p<0.001). Conclusion Our results indicated that WB exerting a glycemic and a serum lipid regulation effect in experimental diabetic rats.
Keywords:
Durum wheat bran, TC, TG, LDL-C and HDL-C, Blood Glucose, diabetic ratsDOI
https://doi.org/10.22270/jddt.v10i2-s.4000References
World Health Organization. World Health Statístcs 2012. Geneva: World Health Organization; 2012. http://www.who.int/gho/publications/world_health_statistics/EN_WHS2012_Full.pdf
Rodney A, Samaan, MD, MPH, Dietary fiber for the prevention of cardiovascular disease. Los Angeles, CA, United States: Elsevier, 2017; p. 1-172 isbn: 978-0-12-805130-6 2 pissn 1011-8934 eissn 1598-6357
Vincent R, Roberts A, Frier M, Perkins A C, Macdonald I A, and Spiller R C, Effect of bran particle size on gastric emptying and small bowel transit in humans: a scintigraphic study. 1995 Aug; 37(2): 216–219. doi: 10.1136/gut.37.2.216
Santosh K,Jha, Hare R, Singh, Pragya P, Dietary Fiber and Human Health: An Introductio. Dietary Fiber for the Prevention of Cardiovascular Disease http://dx.doi.org/10.1016/B978-0-12-805130-6.00001-X
Bocle JC, Champ M, Berta .JL, Les fibres alimentaires : déterminants physicochimiques, définition, aspects analytiques et physiologiques. CahNutr Diét 2005 ; 40(1):15-21
Aymard P, Amélioration nutritionnelle des produits céréaliers par les fibres ; un challenge technologique : Cah Nutr Diét 2010; 45:246-254
Prasad KN, Bondy SC, Dietary fibers their fermented short –chain fatty acids in prevention of human diseases: Bioactive carbohydrates and dietary fibre 2018; 1-21
Garcia-conesa MT, Wilson PD, Plumb GW, Ralph j and Williamson G, Antioxidant properties of 4,40-dihydroxy- 3,30-dimethoxy-beta,beta0-bicinnamic acid (8-8-diferulic acid, non-cyclic form): journal of the science of food and agriculture 1999; 79, 379e384
Moayyedi P, Eamonn M, Quigley M, et al. The Effect of Fiber Supplementation on Irritable Bowel Syndrome: A Systematic Review and Meta-analysis. Am J Gastroenterol 2014;109(9):1367–74
Chalamacharla R B, Harsha k, Sheik k B and Viswanatha c k, wheat bran-composition and nutritional quality: a review. Adv Biotech & Micro 9(1): AIBM.MS.ID. 2018; 555754.
Dagfinn A, Nana k, Edward G, Lars t fadnes, et al. whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies. Intended for healthcare professionals. bmj 2016;353:i2716. (published 14 june 2016)
AFNOR, Aliments des animaux, méthodes d’analyses françaises et communautaires, recueil de normes françaises, 2ième édition, 1985 :131‐134.
Szkudelski T, The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas. Minireview. physiol. res. 50: 536-546, 2001: issn 0862-8408.
Reeves PG, Nielsen FH, Fahey GC Jr, AIN-93 Purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993 Nov;123(11):1939-51.
Winer, B.J, Statistical Principles in Experimental Design. 3rd Edition, New York : McGraw-Hill c, 1991, p. 1-1057
Eun k k, Tae j o, Lee-kyung k, and Young m c, improving effect of the acute administration of dietary fiberenriched cereals on blood glucose levels and gut hormone secretion. Endocrinology, nutrition & metabolism. • j korean med sci, 2016; 31: 222-230 jkms.2016.31.2.222 http://dx.doi.org/10.3346/
Hamid A, Ilyas M,. Kalsoom S et bhatty N, Effects of wheat bran diet and maize bran diet on the random blood glucose and weight of alloxan induced diabetic rats. the journal of animal & plant sciences, 27(1): 2017, page: 325-330 issn: 1018-7081
Ali R, Staub H, Leveille G.A, Boyle PC, Dietary Fiber and Obesity. In: Vahouny G.V., Kritchevsky D. (eds) Dietary Fiber in Health and Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA 1982; DOI https://doi.org/10.1007/978-1-4615-6850-6_13
Rondini l, Peyrat-maillard Mn, Marsset-baglieri A, Fromentin G, Durand P, Tome D, et al. Bound ferulic acid from bran is more bioavailable than the free compound in rat. journal of agricultural and food chemistry, 2004: 52, 4338e
De VF, Mithieux G, Dietary fibers induce metabolic benefits via the activation of intestinal gluconeogenesis. Obésité. Springer-Verlag France. 2014: 1 DOI 10.1007/s11690-014-0451-8
Audrey M. Neyrinck a, Fabienne De Backer A, Patrice D, Cani A, Laure B. Bindels A , Aurore Stroobants B , Daniel Portetelle b , Nathalie M D, Immunomodulatory properties of two wheat bran fractions – aleurone-enriched and crude fractions – in obese mice fed a high fat diet audrey m. international immunopharmacology 2008; 8, 1423–1432
Giacco R, Parillo M, Rivellese AA, et al. Long-term dietary treatment with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients. diabetes care 2000; Oct;23(10):1461-6. DOI:10.2337/diacare.23.10.1461
Jinshan Ji,Chao Z, Xiaoqin L, Li W,Ruijuan Z, Zhenlin W, Daidi F,Haixia Y and Jianjun D, Effect of Stay-Green Wheat, a Novel Variety of Wheat in China, on Glucose and Lipid Metabolism in High-Fat Diet Induced Type 2 Diabetic Rats. Nutrients. 2015 Jul; 7(7): 5143–5155. DOI: 10.3390/nu7075143
Dipesh A, Latha S, Heena L, Neha C and Rajeev K, Whole grains and resistant starch rich, reduced-calorie biscuit diet as a hypoglycaemic, hypolipidaemic and insulin stimulator in streptozotocin-induced diabetic rats. International Journal of Food Science and Technology 2016 ; October DOI: 10.1111/ijfs.13269
Nadine N. Kok, Linda M. Morgan,Christine M. Williams, Marcel B. Roberfroid, Jean-Paul Thissen and Nathalie M, Insulin, Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Insulin-Like Growth Factor I as Putative Mediators of the Hypolipidemic Effect of Oligofructose in Rats. J. Nutr. 128: 1099–1103, 1998
Eva Q S A, Chacko E L, Chou M K and Simin L, Greater Whole-Grain Intake Is Associated with Lower Risk of Type 2 Diabetes, Cardiovascular Disease, and Weight Gain. The Journal of Nutrition, Volume 143, Issue 9, September 2013, Page 1524, https://doi.org/10.3945/jn.113.180281
Wu H, Dwyer Km, Fan Z, Shircore A, Fan J, Dwyer Jh. Dietary fiber and progression of atherosclerosis: the los angeles atherosclerosis study. am j clin nutr 2003; 78: 1085-9 DOI: 10.1093/ajcn/78.6.1085
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