Biochemical and Toxicological Evaluations of Aqueous Extract of Parquetina nigrescens (Afzel.) leaves on Mifepristone-induced Polycystic Ovarian Syndrome in Rats

  • Fehintoluwa Joy Femi-olabisi Biochemistry Unit, Department of Biological Sciences, Mountain Top University, Ogun, Nigeria
  • Opeyemi Faokunla Department of Biochemistry, Federal University Lokoja, Kogi State, Nigeria
  • Anthonia Oluyemi Agboola Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria
  • Imoleayo Moses Olorunyolemi Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria

Abstract

The biochemical and toxicological effects of aqueous extract of Parquetina nigrescens leaves (AEPNL) at the doses of 50, 100, and 200 mg/kg body weight on mifepristone-induced in Polycystic Ovarian Syndrome (PCOS) was investigated in female Wistar rats. Sixty female Wistar rats (190.00 ± 13.00 g) were assigned into 6 groups (A - F) of ten each: animals in group A received 0.5 ml of distilled water orally on daily basis for 30 days while the mifepristonized rats in groups B, C, D and E also received orally 0.5 ml of distilled water, 7.14mg/kg of metformin (reference drug) and same volume of the extract corresponding to 50, 100, and 200 mg/kg body weight of AEPNL respectively after which levels of some biochemical and toxicological indices were determined. AEPNL aggravated mifepristone-treatment related increases in albumin, total protein and liver aspartate aminotransferase activity and mitigated the increases in globulin, total bilirubin, urea, creatinine, liver and serum alkaline phosphatase and alanine aminotransferase activities, and no treatment-related histoarchitectural changes occurred in the liver, kidney and uterus of the female rats. Therefore, the aqueous extract of Parquetina nigrescens leaves attenuated and also aggravated some biochemical parameters in the serum, liver and kidney but with no histological changes in the liver, kidney and uterus of the mifepristonized female Wistar rats.


Keywords: Mifepristone, toxicology, Parquetina nigrescens, Polycystic Ovarian Syndrome, histology

Keywords: Mifepristone, toxicology, Parquetina nigrescens, Polycystic Ovarian Syndrome, histology

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Author Biographies

Fehintoluwa Joy Femi-olabisi, Biochemistry Unit, Department of Biological Sciences, Mountain Top University, Ogun, Nigeria

Biochemistry Unit, Department of Biological Sciences, Mountain Top University, Ogun, Nigeria

Opeyemi Faokunla, Department of Biochemistry, Federal University Lokoja, Kogi State, Nigeria

Department of Biochemistry, Federal University Lokoja, Kogi State, Nigeria

Anthonia Oluyemi Agboola, Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria

Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria

Imoleayo Moses Olorunyolemi, Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria

Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria

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Femi-olabisi FJ, Faokunla O, Agboola AO, Olorunyolemi IM. Biochemical and Toxicological Evaluations of Aqueous Extract of Parquetina nigrescens (Afzel.) leaves on Mifepristone-induced Polycystic Ovarian Syndrome in Rats. JDDT [Internet]. 15Apr.2020 [cited 16Aug.2022];10(2-s):94-01. Available from: https://jddtonline.info/index.php/jddt/article/view/3956