Wound Healing Activity of Calotropis Procera Root Bark on Diabetic Rats

  • Rohit P. Mali Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India
  • Priya S. Rao Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India
  • D.N. Vikhe Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

Abstract

Herbal therapy and herbal medicine in traditional medicine as well as in alternative medicine practiced in the developed world. There is recent most of the harbal formulation are used to cure & improve the humal life. The present study Wound healing activity of Calotropis procera root bark on diabetic rats in that root bark is extracted from ethanolic extract using soxhlet method. The pharmacognostic study was done after that phytochemical characters should be studied. The root bark has alkaloids, Flavonoids, steroids and tannins active constituents.  Acute toxicity study carried out with three pharmacological models Incision model, Excision model, and Dead space model. All the extract show predominant activity against selected species. Extract shows beneficial effect on diabetic wound it heals in time with standard component. Overall results of this study reveals that this is an effective extract on diabetic wound.


Keywords: Traditional medicine, Calotropis procera, Wound Healing Activity

Keywords: Traditional medicine, Calotropis procera, Wound Healing Activity

Downloads

Download data is not yet available.

Author Biographies

Rohit P. Mali, Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

Priya S. Rao, Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

D.N. Vikhe, Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahata Dist-Ahmednagar, India

References

(1) Beyene, B.; Beyene, B.; Deribe, H. Review on Application and Management of Medicinal Plants for the Livelihood of the Local Community. J. Resour. Dev. Manag.2016; 22, 33–39.
(2) Khatri, A.; Garg, A.; Agrawal, S. S. Evaluation of Hepatoprotective Activity of Aerial Parts of Tephrosia Purpurea L. and Stem Bark of Tecomella Undulata. J. Ethnopharmacol.2009; 122 (1), 1–5. https://doi.org/10.1016/j.jep.2008.10.043.
(3) Kirtikar, K. R. Indian Medicinal Plants : By K.R. Kirtikar, B.D. Basu, and An I.C.S. In 4 Volumes.; Lalit Mohan Basu: Allahabad, 1935.
(4) Verma, S. PHARMACOLOGICAL PERSPECTIVES OF CALOTROPIS GIGANTEA (ASCLEPIADACEAE) Sunita Verma. Int. J. Pharmacogn.2016; 3 (9), 405–409. https://doi.org/10.13040/IJPSR.0975-8232.IJP.3(9).405-09.
(5) WATT, J. M.; BREYER-BRANDWIJK, M. G. The Medicinal and Poisonous Plants of Southern Africa: Being an Account of Their Medicinal Uses, Chemical Composition, Pharmacological Effects and Toxicology in Man and Animal; E. & S. Livingstone Ltd.: 16-17, Teviot Place, Edinburgh, 2008; Vol. 132. https://doi.org/10.1038/132336a0.
(6) Al-Qarawi, A. A.; Mahmoud, O. M.; Sobaih, M. A.; Haroun, E. M.; Adam, S. E. I. A Preliminary Study on the Anthelmintic Activity of Calotropis Procera Latex against Haemonchus Contortus Infection in Najdi Sheep. Vet. Res. Commun.2001; 25 (1), 61–70. https://doi.org/10.1023/A:1026762002947.
(7) Saxena, A.; Bhagat, M.; Arora, J. In Vitro Cytotoxicity of Extracts and Fractions of Calotropis Procera (Ait.) Roots against Human Cancer Cell Lines . Int. J. Green Pharm.2010, 4 (1), 36. https://doi.org/10.4103/0973-8258.62165.
(8) Waheed, N.; Jabeen, K.; Iqbal, S.; Javaid, A. BIOPESTICIDAL ACTIVITY OF Calotropis Procera L. AGAINST Macrophomina Phaseolina. African J. Tradit. Complement. Altern. Med. AJTCAM2016, 13 (6), 163–167. https://doi.org/10.21010/ajtcam.v13i6.23.
(9) Kumar, V. L.; Basu, N. Anti-Inflammatory Activity of the Latex of Calotropis Procera. J. Ethnopharmacol.1994, 44 (2), 123–125. https://doi.org/https://doi.org/10.1016/0378-8741(94)90078-7.
(10) Deshmukh, P. T.; Gupta, V. B. Embelin Accelerates Cutaneous Wound Healing in Diabetic Rats. J. Asian Nat. Prod. Res.2013, 15 (2), 158–165. https://doi.org/10.1080/10286020.2012.758634.
(11) Deshmukh, P. T.; Fernandes, J.; Atul, A.; Toppo, E. Wound Healing Activity of Calotropis Gigantea Root Bark in Rats. J. Ethnopharmacol.2009, 125 (1), 178–181. https://doi.org/10.1016/j.jep.2009.06.007.
(12) Rasik, A. M.; Raghubir, R.; Gupta, A.; Shukla, A.; Dubey, M. P.; Srivastava, S.; Jain, H. K.; Kulshrestha, D. K. Healing Potential of Calotropis Procera on Dermal Wounds in Guinea Pigs. J. Ethnopharmacol.1999, 68 (1–3), 261–266. https://doi.org/10.1016/S0378-8741(99)00118-X.
Statistics
421 Views | 431 Downloads
How to Cite
1.
Mali RP, Rao PS, Vikhe D. Wound Healing Activity of Calotropis Procera Root Bark on Diabetic Rats. JDDT [Internet]. 15Apr.2020 [cited 18Aug.2022];10(2-s):86-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3955