The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources

  • Radheshyam Samanta Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India
  • Asish Bhaumik Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India
  • Amit Kumar Nayak Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

Abstract

The main aim and objective of my present research work was to determine the various important mucoadhesive parameters such as mucoadhesive force, force of adhesion and bonding strength etc. Mucoadhesive properties of natural polymers were evaluated by formulating gels using Carbopol 940 P as a gelling agent. Mucoadhesive parameters of the prepared Carbopol 940 P gels containing natural polymers were determined by ex vivo followed by modified physical balance using excised cock intestinal mucosa. From the recent experimental data it was displayed that the mucoadhesive strength, force of adhesion and bonding strength of gel containing low methoxy pectin (1 % w/v) was found higher than other tested gels. The gel containing Moringa oleifera gum (1 % w/v) exhibited less mucoadhesion than other tested gels. The order of mucoadhesion of these plant-derived polymers was found as: low methoxy pectin > jackfruit seed starch > cashew gum/okra gum gum > pumpkin pectin > linseed mucilage > sago starch > gum Arabic > xanthan gum > fenugreek seed mucilage/black palm seed polysaccharide > Moringa oleifera gum.


Keywords: Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, and plant derived polymers etc.

Keywords: Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, plant derived polymer

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Author Biographies

Radheshyam Samanta, Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Asish Bhaumik, Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Amit Kumar Nayak, Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

References

[1] Chowdary KPR, Srinivas L. Mucoadhesive drug delivery systems: a status of current review. Indian Drugs 2000; 37: 400-406.
[2] Patil SB, Murthy RSR, Mahajan HS, Wagh RD, Gattani SG. Mucoadhesive polymers: Means of improving drug delivery. Pharma Times 2006; 38: 25-28.
[3] Pal D, Nayak AK. Development, optimization, and anti-diabetic activity of gliclazide-loaded alginate-methyl cellulose mucoadhesive microcapsules. AAPS PharmSciTech 2011; 12: 1431-1441.
[4] Pal D, Nayak AK. Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: In vitro-in vivo evaluation. Drug Deliv 2012; 19: 123-131.
[5] Chowdary KPR, Srinivas Rao S. Mucoadhesive microspheres and microcapsules: Current status. Indian J Pharm Sci 2005; 67: 141-150.
[6] Kibbe AH. Handbook of pharmaceutical excipients. Pharmaceutical Press: Washington, D.C. USA, 2000: pp. 102-109.
[7] Pal D, Nayak AK, Kalia S. Studies on Basella alba L. leaves mucilage: Evaluation of suspending properties. Int J Drug Discov Tech 2010; 1(1): 15-20.
[8] Nayak AK, Pal D, Pany DR, Mohanty B. Evaluation of Spinacia oleracea L. leaves mucilage as innovative suspending agent. J Appl Pharm Tech Res 2010; 1(3): 338-341.
[9] Jani GK, Shah DP, Prajapati VD, Jain V. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2009; 4(5): 309-323.
[10] Avachat AM, Dash RR, Shrotriya SN. Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Indian J Pharm Educ Res. 2011; 45(1): 86-99.
[11] Barbosa MA, Granja PL, Barrias CC, Amaral IF. Polysaccharides as scaffolds for bone regeneration. ITBM-RBM 2005; 26: 212-217.
[12] Patil SB, Murthy RSR, Mahajan HS, Wagh RD, Gattani SG. Mucoadhesive polymers: Means of improving drug delivery. Pharma Times 2006; 38(4): 25-28.
[13] Nayak AK, Hasnain MS, Beg S, Alam MI. Mucoadhesive beads of gliclazide: Design, development, and evaluation. Sci Asia 2010; 36: 319-325.
[14] Sharma VK, Bhattacharya A. Release of metformin hydrochloride from ispaghula-sodium alginate beads adhered on cock intestinal mucosa. Indian J Pharm Educ Res 2008; 42 (4): 365-372.
[15] Sachan NK, Bhattacharya A. Evaluation of Assam Bora rice starch as a possible natural mucoadhesive polymer in formulation of microparticulate controlled drug delivery systems. J Assam Sci Soc 2006; 47: 34-41.
[16] Basu S, Chakraborty S, Bandyopadhyay AK. Development and evaluation of a mucoadhesive nasal gel of midazolam prepared with Linum usitatissimum L. seed mucilage. Sci Pharm 2009; 77: 899-910.
[17] Gheraldi E, Tavanti A, Celandroni F, Lupetti A, Blandizzi C, Boldrini E, Campa M, Senesi S. Effect of novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits. J Antimicrob Chemother 2000; 46: 831-834.
[18] Ketousetuo K, Bandyopadhyay AK. Development of oxytocin nasal gel using natural mucoadhesive agent obtained from the fruits of Dellinia indica. L. Sci Asia 2007; 33: 57-60.
[19] Dutta R, Bandyopadhyay AK. Development of a new nasal drug delivery system of diazepam with natural mucoadhesive agent from Trigonella foenum-graecum L. J Sci Ind Res 2005; 64: 973-977.
[20] Chanda R, Nath LK, Mahapatra SK. Formulation development of oral mucoadhesive coated terbutaline sulphate tablets using some natural materials extracted from edible fruits available in India. Iranian J Pharm Res 2009; 5(1): 3-12.
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Samanta R, Bhaumik A, Nayak AK. The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources. JDDT [Internet]. 15Apr.2020 [cited 18Aug.2022];10(2-s):27-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3952