The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources

Authors

  • Radheshyam Samanta Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India
  • Asish Bhaumik Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India
  • Amit Kumar Nayak Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

Abstract

The main aim and objective of my present research work was to determine the various important mucoadhesive parameters such as mucoadhesive force, force of adhesion and bonding strength etc. Mucoadhesive properties of natural polymers were evaluated by formulating gels using Carbopol 940 P as a gelling agent. Mucoadhesive parameters of the prepared Carbopol 940 P gels containing natural polymers were determined by ex vivo followed by modified physical balance using excised cock intestinal mucosa. From the recent experimental data it was displayed that the mucoadhesive strength, force of adhesion and bonding strength of gel containing low methoxy pectin (1 % w/v) was found higher than other tested gels. The gel containing Moringa oleifera gum (1 % w/v) exhibited less mucoadhesion than other tested gels. The order of mucoadhesion of these plant-derived polymers was found as: low methoxy pectin > jackfruit seed starch > cashew gum/okra gum gum > pumpkin pectin > linseed mucilage > sago starch > gum Arabic > xanthan gum > fenugreek seed mucilage/black palm seed polysaccharide > Moringa oleifera gum.

Keywords: Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, and plant derived polymers etc.

Keywords:

Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, plant derived polymer

DOI

https://doi.org/10.22270/jddt.v10i2-s.3952

Author Biographies

Radheshyam Samanta, Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Asish Bhaumik, Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India

Amit Kumar Nayak, Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India.

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Published

15-04-2020
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How to Cite

1.
Samanta R, Bhaumik A, Nayak AK. The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources. J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):27-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3952

How to Cite

1.
Samanta R, Bhaumik A, Nayak AK. The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources. J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):27-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3952