Antiinflammatory activity of Albizia lebbeck (L.) BENTH
Albizia lebbeck (L.) BENTH (Fabaceae), popularly known as Sirisha, is employed in Indian folk medicine for the treatment of boils, cough, pain, swelling and it is also used against diarrhea. The anti-inflammatory activity was assessed using acute and subacute models of inflammation in rats. These studies demonstrated that oral administration of ethyl acetate extract of Albizia lebbeck (EAL) (100, 200, 400 mg/kg) exhibited significant anti-inflammatory activity. In acute inflammation as produced by carrageenan 62.19% after 5h, by histamine 43.19%, by dextran 45.29%, by serotonin 68.84 while in subacute anti-inflammatory model using formaldehyde-induced hind paw edema (after 5 h) 31.5% and cotton pellets 13.48% protection from inflammation was observed at 400 mg/kg orally dose of EAL. EAL neither show ulcerogenic effect at different doses of EAL nor show any sign of toxicity and mortality up to a dose level of 5000 mg/kg, p.o. in rats & mice. These data indicate that EAL possesses significant anti- anti-inflammatory activity.
Keywords: Acute toxicity, Anti-inflammatory, Albizia lebbeck.
2. Anonymous, The Wealth of India: A Dictionary of Indian raw materials & industrial products, Raw Materials, Vol 10 (Sp-W). New Delhi: National Institute of Science Communication and Information Resources (CSIR); 1993. p. 195-200.
3. Envis Centre on Medicinal Plants. Encyclopedia on Indian Medicinal Plants. http://envis.frlht.org/plant_details.php?disp_id=642&parname=0. Accessed on: 05.03.18.
4. The Useful Plants of India. National Institute of Science Communication & Information Resources (CSIR), 5th ed. New Delhi, India; 2006. p. 141.
5. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Dehra Dun, India: Bishen Singh Mahendra Pal Singh; 1993. p. 549-559.
6. Gupta AK, Sharma Madhu. Reviews on Indian Medicinal Plants. Vol 7 (CI-Co). Medicinal Plant Unit. Indian Council of Medical Research. New Delhi, India; 2008. p. 561-562.
7. Asolkar LV, Kakkar KK, Charke OJ. Glossary of Indian medicinal plants with active principles, Part 1. New Delhi: National Institute of Science Communication And Information Resources (CSIR); 1992. p. 230-231.
8. Bobby N M. D., Wesely, E. G, Johnson, M. 2012; HPTLC studies on the flavonoids of albizia lebbeck benth, International Journal of Advances in Pharmaceutical Research,Research Paper Vol. 3 / Issue. 3 / 830 – 836.
9. Alam P; Ali M. Aeri, Vidhu. 2012; Isolation of a new keto steroid stigmast-4, 20(21), 23-trien-3-one and a new alcohol tricontan-10a-ol from the roots of Albizzia lebbeck Benth,Journal of Natural Product & Plant Resources; Vol. 2 Issue 2, pp 234.
10. Albizia lebbeck bark spectral analysis molecular conformation chemical constituents of plants chemical structure. Phytochemistry. v. 38 (5).
11. Chaddha Varun., Nayak S., Solanki Sarita., 2011; Preliminary Phytochemical Screening On Bark and Pods Of Albizzia Lebbeck Linn, International Journal Of Comprehensive Pharmacy, 11 (06).
12. Uma B., Prabhakar K., Rajendran S., Sarayu L.Y. 2009; Antimicrobial Activity of Albizzia Lebbeck Benth against Infectious Diarrhoea. The Internet Journal of Microbiology Vol 7 Number 1.
13. Steinrut L, Itharat A, Ruangnoo S. Free radical scavenging and lipid peroxidation of Thai medicinal plants used for diabetic treatment. J Med Assoc Thai 2011; 7: 178-82.
14. Aliyu AB, Musa AM, Ibrahim MA, Ibrahim H, Oyewale AO. Preliminary phytochemical screening and antioxidant activity of leave extract of Albizia chevalieri harms (leguminoseae-mimosoideae). Bajopas 2008; 2(1): 149-153.
15. Zheng L, Zheng J, Zhao Y, Wang B, Lijun W, Liang H. Three anti-tumor saponins from Albizia julibrissin. Bioorg Med Chem Lett 2006; 16: 2765–2768.
16. Miyase T, Melek FR, Ghaly NS, Warashina T, El-Kady M, Nabil M. Echinocystic acid 3, 16-O-bisglycosides from Albizia procera. Phytochem 2010; 71(11-12): 375-80.
17. Sabrina K, Odile T, Thierry S, Richard W, Catherine L. Triterpenoid saponin anthranilates from Albizia grandibracteata leaves ingested by primates in Uganda. J of Nat Prod 2005; 68: 897–903.
18. Melek FR, Miyase T, Ghaly NS, Nabil M. Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera. Phytochem 2007; 68: 1261–1266.
19. Rui L, Shuanggang M, Shishan Y, Yuehu P, Sen Z, Xiaoguang C, Jianjun Z. Cytotoxic oleanane triterpene saponins from Albizia chinensis. J Nat Prod 2009; 72: 632–663.
20. Not OP, Offer AM, Miyamoto T, Paululat T, Mirjolet J, Duchamp O, Pegnyemb D, Dubois ML. Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. J Nat Prod 2009; 72: 1725–1730.
21. Zou, K, ZhaoYY, Zhang RY. A cytotoxic saponin from Albizia julibrissin. Chem Pharm Bull (Tokyo) 2006; 54(8): 1211-2.
22. Lau, CS, Carrier DJ, Beitle RR, Bransby DI, Howard LR, Lay JJ, Liyanage R, Clausen EC. Identification and quantification of glycoside flavonoids in the energy crop Albizia julibrissin. Bioresour Technol 2007; 98: 429-435.
23. Kang TH, Jeong SJ, Kim NY, Higuchi R, Kim YC. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin. J Ethnopharmacol 2000; 71: 321–323.
24. Yadava RN, Tripathi P. Chemical examination and anti-inflammatory action of the extract from the stem of Albizia procera. Res J Chem Environ 2000; 4: 57-60.
25. Correia da Silva AC, Paiva MQ, Costa A. Some aspects of the physiological actions of the alkaloids of Dioscorea dumetorum French and English summ. An Fac Farm Porto 1962; 22: 51-66.
26. Mar W, Tan GT, Cordell GA, Pezzuto JM, Jurcic K, Redl K, Steinke B, Wagner H. Biological activity of novel macrocyclic alkaloids (Budmunchiamines) from Albizia amara detected on the basis of interaction with DNA. J Nat Prod 1991; 54: 1531-1542.
27. OECD guidelines for the testing of chemicals (Acute oral toxicity – Fixed dose procedure). www.oecd.org. Assessed on: 11September 2017.
28. Winter CA, Risley EA, Nuss GW (1962). Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 111: 544-547.
29. Suleyman H, Demirezer LO, Kuruuzum A, Banoglu ZN, Gocer F, Ozbakir G, Gepdiremen A (1999). Anti-inflammatory effect of the aqueous extract from Rumex patientia L. roots. Journal of Ethnopharmacology 65: 141-148.
30. Winter CA, Porter CC (1957). Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities in hydrocortisone esters. Journal of the American Pharmaceutical Association 46: 515-519.
31. Mukherjee PK, Saha K, Das J, Pal M, Saha BP (1997). Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Medica 63: 367-369.
32. Brownlee G (1950). Effect of deoxycotone and ascorbic acid on formaldehyde induced arthritis in normal and adrenalectomized rats. The Lancet 255: 157-159.
33. Swingle KF, Shideman FE (1972). Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents. Journal of Pharmacology and Experimental Therapeutics 183: 226-234.
34. Yatzidis H (1977). An improved Biuret reagent. Clinical Chemistry 23: 908.
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