Phytochemical Screening and Anti-Diabetic and Anti-Hyperlipidemic Activity of Ethanolic Fruits Extract of Scindapsus Officinalis (Roxb)

  • Pawan Tiwari Department of Pharmaceutical Chemistry, Bhupal Nobel University, Udaipur, Rajasthan, India.
  • Anju Goyal Department of Pharmaceutical Chemistry, Bhupal Nobel University, Udaipur, Rajasthan, India.


The present research work emphasized on evaluates the Phytochemical & Pharmacological activities of the fruits of Scindapsus Officinalis (Roxb) (Araceae). The fruits of the plant were shade dried, reduced to coarse powder with the help of grinder was subjected to successive soxhlet extraction with Petroleum Ether and 90% v/v Ethanol (Emparta). The various extracts were then subjected to preliminary phytochemical screening which revealed the presence of flavonoids, saponins, tannins, phenols, carbohydrate, lipids, alkaloids & steroids. Selection of active extract for in vivo studies was based on preliminary phytochemical tests and in vitro glucose diffusion inhibition potential and accordingly, ethanolic extracts were chosen for further studies. The pharmacological screening included evaluation of the antidiabetic and hypolipidemic activity of ethanolic extracts (200mg/kg and 400mg/kg b.w) on Streptozotocin-induced diabetic rats. The ethanolic extract was found to be more effective and brought about significant antidiabetic & hypolipidemic potential. This was due to the presence of one or more phytoconstituents present in ethanol extract.

Keywords: Scindapsus Officinalis (Roxb); Antidiabetic; Anti-hyperlipidemic; Streptozotocin.


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1. Bergman, R.N. and Ader, M., 2000. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends in Endocrinology & Metabolism 11, 351-356.
2. Zhang, X., and Tan, B.K.H., 2002. Antihyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats. Clinical and Experimental Pharmacology and Physiology 27, 358-63.
3. Rang, H.P., Dale M.M., Ritter, J.M., Moore, P.K., 2003. Pharmacology, 5th edition. Churchill Livingstone, Actions of Insulin 382-384.
4. Tuomilehto, J., Lindstrom, J., Eriksson, J.G., 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. The New England Journal of Medicine 344, 1343–1350.
5. Atkinson, M.A., Maclaren, N.K., 1994. The pathogepesis of insulin dependent diabetes. The New England Journal of Medicine 331, 1428-1436.
6. Alberti, K.G., Zimmet, P.Z., 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Medicine 15, 539.
7. Kolterman, O.G., Gray, R.S., Griffin, J., Burstein, P., Insel, J., Scarlett, J.A., Olefsky, J.M., 1985. Receptor and postreceptor defects contribute to the insulin resistance in noninsulindependent diabetes mellitus. The Journal of Clinical Investigation 68, 957-969.
8. Abate, N., Chandalia, M., 2003. The impact of ethnicity on type 2 diabetes. Journal of diabetes and its Complications 17, 39–58.
9. Ward, W.K., Beard, J.C., Porte, D., 1986. Clinical aspects of islet β cell function in non-insulin dependent diabetes mellitus. Diabetes and metabolism review 2, 297–31.
10. Kuusisto, J., Mykknen, L., Pyorala, K., Laakso, M., 1994. NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes 43,960-967.
11. Engelgau, M.M., Herman, W.H., Smith, P.J., German, R.R., Aubert, R.E., 1988. The epidemiology of diabetes and pregnancy in the U.S. Diabetes Care 18, 1029- 1033.
12. Coustan, D.R., 1995. Gestational diabetes. In Diabetes in America. 2nd ed. Washington, DC, U.S. Govt. Printing Office, (NIH- pubi. no. 95-1468), 703-717.
13. Seshiah, V., Balaji, V., Balaji, M.S., 2009. Pregnancy and diabetes scenario around the world: India. International Journal of Gynecology and Obstetrics 104(1), S35-8.
14. American Diabetes Association, 2004. Gestational Diabetes Mellitus (Position Statement). Diabetes Care 27 (Suppl 2), S88-90.
15. Gruppuso, P.A., Gorden, P., Kahn, C.R., Cornblath, M., Zelle,r W.P., Schwartz, R., 1984. Familial hyperproinsu1inemia due to a proposed defect in conversion of pro insulin to insulin. The New England Journal of Medicine 311, 629-634.
16. Costa, A., et al. 2000. Genetic and Clinical Characterisation of Maturity-Onset Diabetes Of The Young In Spanish Families. European Journal of Endocrinology 142, 380–386. Yamagata, K., Faruta, H., Oda, N., 1996. Mutations in the hepatocyte nuclear factor-4 alpha gene in MODY 1. Nature 384, 458-60.
17. Yamagishi, S., Fujimori, H., Yonekura, H., Yamamoto, Y., Yamamoto, H., 1998. Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells. Diabetologia 41, 1435–1441.
18. Forrest, J.A, Menser, M.A., Burgess, J.A., 1971. High frequency of diabetes mellitus in young patients with congenital rubella. Lancet ii: 332-334.
19. Jones, O.A., Maguire, M.L., Griffin, J.L., 2008. Environmental pollution and diabetes: a neglected association. Lancet 371(9609), 287-288.
20. Hyman, M., 2007. Systems biology, toxins, obesity, and functional medicine. Alternative Therapies, Health and Medicine 13(2), S134-S139.
21. Navas-Acien, A., Silbergeld, E.K., Pastor-Barriuso, R., Guallar, E., 2008. Arsenic exposure and prevalence of type 2 diabetes in US adults. The Journal of the American Medical Association 300(7), 814-822.
22. Remillard, R.B., Bunce, N.J., 2002. Linking dioxins to diabetes: epidemiology and biologic plausbility. Environmental Health Perspective 110(9), 853-858.
23. Eizirik, D., Pipeleers, D., Ling, Z., Welsh, N., Hellerstrom, C., Andersson, A., 1994. Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proceedings of the National Academy of Sciences USA91, 9253-9256.
24. Hardt, P.D., Krauss, A., Bretz, L., Porsch-Ozcurume, M., Schnell-Kretschmer, H., Maser, E., 2000. Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus. Acta Diabetologica 37, 105-10.
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Tiwari P, Goyal A. Phytochemical Screening and Anti-Diabetic and Anti-Hyperlipidemic Activity of Ethanolic Fruits Extract of Scindapsus Officinalis (Roxb). JDDT [Internet]. 12Dec.2019 [cited 14Jun.2021];9(4-s):1072-86. Available from: