An Overview : Natural Bio-enhancer’s in Formulation Development
Abstract
Bioenhancers are chemical entities that are obtained from synthetic as well as natural sources. They are mainly used in formulation development to enhance the bioavailability of poorly solubilized drug molecule. The ideal characteristic of bioenhancers includes inertness, nontoxic, cost effective and decrease the dose of active constituents. There are lots of natural bioenhancers available such as piperine quercetin niaziridin, genistein, glycrrhyzin, curcumin. The review focus on plant based bioenhancers and their active principle that produces those effects. There is a need of extensive study on natural bioenhancers which can be utilized in formulation development.
Keywords: bioenhancer, bioavailability, piperine, curcumin
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References
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2. Chow SC. Bioavailability and Bioequivalence in Drug Development. Wiley Interdiscip Rev Comput Stat. 2014;6(4):304-12.
3. Savjani KT, Gajjar AK, Savjani JK. Drug solubility: importance and enhancement techniques. ISRN pharmaceutics. 2012;2012.
4. Lach J. Some factors affecting bioavailability of drug products. Journal of the Iowa Medical Society. 1972;62(8):441-2 passim.
5. Verma P, Thakur A, Deshmukh K, Jha A, Verma S. Routes of drug administration. International Journal of Pharmaceutical Studies and Research. 2010;1(1):54-9.
6. Atal N, Bedi K. Bioenhancers: Revolutionary concept to market. Journal of Ayurveda and integrative medicine. 2010;1(2):96.
7. Kesarwani K, Gupta R. Bioavailability enhancers of herbal origin: An overview. Asian Pacific journal of tropical biomedicine. 2013;3(4):253-66.
8. Tannergren C, Bergendal A, Lennernäs H, Abrahamsson B. Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment. Molecular pharmaceutics. 2009;6(1):60-73.
9. Hayton WL. Rate-limiting barriers to intestinal drug absorption: a review. Journal of pharmacokinetics and biopharmaceutics. 1980;8(4):321-34.
10. Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced drug delivery reviews. 2012;64:138-53.
11. Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet. 2001;40(3):159-68.
12. Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Advanced drug delivery reviews. 2001;46(1-3):89-102.
13. Dudhatra GB, Mody SK, Awale MM, Patel HB, Modi CM, Kumar A, et al. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. 2012;2012.
14. Prasad R, Singh A, Gupta N, Tarke C. Role of Bioenhancers in Tuberculosis. International journal of health sciences and research. 2016;3076.
15. Javed S, Ahsan W, Kohli KJJSL. The concept of bioenhancers in bioavailability enhancement of drugs–a patent review. 2016;1:143-65.
16. Tatiraju DV, Bagade VB, Karambelkar PJ, Jadhav VM, Kadam VJJPP. Natural bioenhancers: An overview. 2013;2(3):55-60.
17. Singh S, Tripathi J, Rai N. An appraisal of the bioavailability enhancers in Ayurveda in the light of recent pharmacological advances. 2016;37(1):3-10.
18. Shanmugam SJCPB. Natural Bioenhancers: Current Outlook. 2015;4:e116.
19. Randhawa GK, Jagdev Singh Kullar RJIjoa, research bm. Bioenhancers from mother nature and their applicability in modern medicine. 2011;1(1):5.
20. Singh R, Devi S, Patel J, Patel U, Bhavsar S, Thaker AJPR. Indian herbal bioenhancers: a review. 2009;3(5):90.
21. Chivte V, Tiwari S, Pratima A, Nikalge G. BIOENHANCERS: A BRIEF REVIEW. 2017.
22. Mukhopadhyay N, Khan S, Aswatha RHJJoGPT. Natural bio-enhancers: Scope for newer combinations-a short review. 2018;10(11):1-4.
23. Jain G, Patil UKJIJPSR. Strategies for enhancement of bioavailability of medicinal agents with natural products. 2015;6(12):5315-24.
24. Shukla M, Malik M, Jaiswal S, Sharma A, Tanpula D, Goyani R, et al. A mechanistic investigation of the bioavailability enhancing potential of lysergol, a novel bioenhancer, using curcumin. 2016;6(64):58933-42.
25. Ogita A, Fujita K-i, Tanaka TJPm. Enhancement of the fungicidal activity of amphotericin B by allicin: effects on intracellular ergosterol trafficking. 2009;75(03):222-6.
26. Yurdakok-Dikmen B, Turgut Y, Filazi AJFivs. Herbal Bioenhancers in Veterinary Phytomedicine. 2018;5.
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Verma C, Verma S, Ashawat MS, Pandit V. An Overview : Natural Bio-enhancer’s in Formulation Development. JDDT [Internet]. 15Nov.2019 [cited 2Oct.2023];9(6):201-5. Available from: https://jddtonline.info/index.php/jddt/article/view/3682
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