A New Spectrophotometric Method for the Determination of Itraconazole Based on the Oxidation Reaction
The solubility of Itraconazole (Itcz) in various solvents such as distilled water, hydrochloric acid and sulphuric acid in presence of cationic and anionic surfactant i.e. cetyl trimethyl ammonium bromide (CTAB) and sodium lauryl sulphate (SLS) was examined. It has been found that SLS greatly enhanced the solubility of Itraconazole by 13 fold. A simple spectrophotometric method has been proposed for the determination of Itraconazole in pure and pharmaceutical formulation by ammonium metavanadate in presence of SLS. The method is based on the formation of wine red colored species on treating Itcz with ammonium metavanadate at CMC of SLS i.e. 0.0008M. The wine red species (due to reduced V(v)) exhibiting maximum absorbance at 385 nm.
Keywords: Itraconazole, sodium lauryl sulphate, solubility
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