Formulation and evaluation of Antiurolithiatic herbal tablet
Phytomedicine based on principles of Ayurveda are need of the hour and is more feasible than allopathic drugs which is not only more expensive in terms of “leads” but is also associated with many unwanted effects. Ethnopharmacological usage and the literature review revealed that the Abutilon indicum, Zea mays, Tribulus terrestris, Phyllanthus niruri have significant antiurolithiatic activity. After the detailed study of powder of ethanolic extract of seeds of abutilon indicum, tassel of zea mays,fruits of Tribulus terrestris and leaves of Phyllanthus niruri a formulation using the plant materials was prepared. The formulation was evaluated and standardized as per the Pharmacopoeial standards. The results of preformulation studies revealed that all the values were within acceptable limit. Formulation showed appreciable hardness characteristics (4.35 kg/cm2), which facilitates its fast disintegration. The friability (0.8%) of formulation indicated that the tablets were mechanically stable. As the average weight of tablets was 505 mg, the acceptable weight variation range is ±7%. Hence the entire formulated tablet passed the weight variation test. The disintegration time of formulations was more than 1 minute. Thus the claims made by the traditional Indian systems of medicine regarding the use of this plant in the treatment of antiurolithiatic activity confirmed. The final conclusion drawn from the above mentioned data is that the possible use of these economical and relatively nontoxic, non-hazardous natural remedies of plant origin may further be explored as they are devoid of major side effects associated with synthetic agents.
Keywords: Abutilon indicum, Zea mays , Tribulus terrestris, Phyllanthus niruri , Disintegration, Preformulation
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