Synthesis and Anti-Oxidant Activity of Phenol and Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline
N, N’-diprotonation is very easier for pyrazine Synthesis of 2, 3-diphenylquinoxaline by phenylene-diamine in 16 ml of rectified spirit was added & combine solution was warm in water bath for 30 min. added water until slight colorless persist & allow to cool recrystallize the product in ethanol. Synthesis of 2, 3-diphenylquinoxaline 7-sulfonylchloride (R) using chlorosulfonic acid under ice-cold condition, thenSynthesis of 2-hydroxyphenyl-2,3-diphenylquinoxaline-7-sulphonate (R1) throughresorcinol with 3ml pyridine &sulphonyl chloride derivative, Synthesis of 2-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate (R7)obtained by reaction of salicylaldehyde with pyridine &sulphonyl chloride derivative then Synthesis of 3-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate (R9) obtained by heating on water bath mixture of 3-hydroxybenzaldehyde with pyridine &sulphonyl chloride, Synthesized quinoxaline derivatives were subjected to antioxidant activity.Hydrogen peroxide solution (40 mM) was prepared with standard phosphate buffer (pH 7.4). Different concentration of the compound stock solution and 4ml distilled water was added to 0.6 ml of hydrogen peroxide solution. Absorbance was determined at 230 nm after 10 min against a blank solution containing phosphate buffer without hydrogen peroxide. DPPH radical scavenging activity was measured using the method of Cotelleet al. with some modifications. 3 ml of reaction mixture containing 0.2 ml of DPPH (100 μM in methanol) 2.8 ml of test solution, at various concentrations (5, 10, 20, 40, 80, 160 320 μg/ml) of the extract fractions was incubated at 37°C for 30 min absorbance of the resulting solution was measured at 517 nm using Beckman model DU-40 spectrophotometer. Most of the derivatives have shown comparable antioxidant activity in relation to standard Ascorbic acid and DPPH
Keywords: DPPH,Quinoxaline, Antioxidant activity,Sulfonyl chloride quinoxaline.
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