Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles

  • K. Venkata Ramana Reddy
  • Jaideep Gupta
  • Pathan Izharuddin

Abstract

Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques.


Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technology

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Author Biographies

K. Venkata Ramana Reddy

Research Scholar*, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India- 522 510

Jaideep Gupta

KVK College of Pharmacy, Surmaiguda, Ranga Reddy Dist, Telangana State-501512

Pathan Izharuddin

KVK College of Pharmacy, Surmaiguda, Ranga Reddy Dist, Telangana State-501512

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Ramana Reddy KV, Gupta J, Izharuddin P. Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles. JDDT [Internet]. 25Aug.2019 [cited 18Jun.2021];9(4-s):774-81. Available from: https://jddtonline.info/index.php/jddt/article/view/3413