Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles
Abstract
Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques.
Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technology
DOI
https://doi.org/10.22270/jddt.v9i4-s.3413References
Sugiura S, Oda T, Izumida Y, Aoyagi Y, Satake M, Ochiai A, Ohkohchi N, Nakajima M., Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials. 2005; 26:3327-3331.
Serp D, Cantana E, Heinzen C, Von Stockar U, Marison I.W., Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol. Bioeng. 2000; 70:41–53.
Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210:493-499.
Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210: 493- 499.
Canaple L, Rehor A, Hunkeler D., Improving cell encapsulation through size control. J. Biomater. Sci. Polym. 2002; 13:783-796.
Robitaille R, Pariseau J.F, Leblond F.A, Lamoureux M, Lepage Y, Halle J.P., Studies on small l (<350´m) alginate-poly-L-lysine microcap sules. III. Biocompatibility of smaller versus standard microcapsules. J. Biomed. Mater. Res. 1999; 44:116-120.
Maria Raytchinova Kosseva., Immobilization of Microbial Cells in Food Fermentation Processes. Food Bioprocess Technol. 2011; 4:1089-1118.
Serp D, Cantana E, Heinzen C, Von Stockar U, Marison I., Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol. Bioeng. 2000; 70: 41-53
Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210: 493-499.
Yan Zhou , Shinichiro Kajiyama , Hiroshi Masuhara, Yoichiro Hosokawa, Takahiro Kaji, Kiichi Fukui., A new size and shape controlling method for producing calcium alginate beads with immobilized proteins. J. Biomedical Science and Engineering, 2009; 2:287-293.
Boyd J, Parkinson C, Sherman P., Factors affecting emulsion stability, and the HLB concept. J. Colloid Interface Sci. 1972; 4:359-370.
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