Antiproliferative Effect of Ethanolic Medicinal Fungus Extract of Agaricus bisporus on HEP2 Cancer cell lines

  • G Priya
  • Nasreen Najeeb
  • , Thenmozhi

Abstract

This study aims to determine the anti-proliferative effect of fungus Agaricus bisporus. Phytochemical analysis was performed and antiproliferative activity of Agaricus bisporus was analyzed by MTT assay The preliminary phytochemical screening of Agaricus bisporus revealed the presence of phenolics, carbohydrates alkaloids, flavonoids and tannins. The Antiproliferative potential of the ethanol extract was studied on Hep2 cell lines by MTT assay. The extract had an IC50 value of 100μg/mL which showed cell viability.  Thus, the study revealed that Agaricus bisporus could be considered as a significant source of phytochemicals and can act as antiproliferative agent.


Keywords: Phytochemical, antiproliferative, Agaricus bisporus, DPPH assay, Hep2 cell line.

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Priya G, Najeeb N, Thenmozhi ,. Antiproliferative Effect of Ethanolic Medicinal Fungus Extract of Agaricus bisporus on HEP2 Cancer cell lines. JDDT [Internet]. 14Aug.2019 [cited 18Jun.2021];9(4-s):382-5. Available from: https://jddtonline.info/index.php/jddt/article/view/3340