Preparation of Polymer Nanocomposites for Enhancement of Solubility and Dissolution Rate of BCS Class II Drug
Dissolution and diffusion through the gastrointestinal membrane are the mechanisms by which drugs get absorbed on oral administration. The major challenge in the case of most of the drugs is poor water solubility. Hence the main aim of the present study is to develop Nanocomposites by microwave-assisted technique to enhance solubility and dissolution of poorly water-soluble drug Fenofibrate. Synthetic polymers such as PVP K30 was selected for Nanocomposites preparation based on it's wetting and surface active agent property. Nanocomposites were prepared by Microwave-assisted technique and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. The solubility and dissolution enhancing the performance of Nanocomposites were assessed by In-vitro solubility and dissolution studies. It was demonstrated that the dissolution of Fenofibrate enhanced with an increase in polymer concentration. The optimized ratio of drug and polymer for the entire composite was found to be 1:9 Nanocomposites with PVP K30. The Microwave-assisted technique employed in this study as a green and cost-effective method for Nanocomposites formation. Enhancement in the solubility might be because of the generation of drug dispersion at nanoscale levels. So the development of Nanocomposites is a promising approach to increase solubility and dissolution of poorly water-soluble drugs.
Keywords: Nanocomposites, BCS class II drug Solubility, Polymers, Dissolution, Microwave assisted technique.
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