Review on Teneligliptin: A novel antihyperglycemic agent

  • V. D. Gorde
  • Punit R. Rachh


Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or insulin resistance or both. Dipeptidyl peptidase-4 (DPP-4) inhibitors have recently emerged as a new class of antidiabetic that show favorable results in improving glycemic control with a minimal risk of hypoglycemia and weight gain. Teneligliptin is a recently developed oral dipeptidyl peptidase 4 inhibitor indicated for the management of type 2 diabetes mellitus. Teneligliptin, characterized by a "J-shaped" structure formed by five consecutive rings which give unique binding characteristics, reflect in higher potency than other dipeptidyl peptidase 4 inhibitor. Teneligliptin is a novel antihyperglycemic agent with a preferable profile in terms of long-term efficacy and safety in patients with type 2 diabetes.

Keywords: Diabetes Mellitus, Dipeptidyl Peptidase 4 Inhibitor, Teneligliptin, Hypoglycemia,


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Author Biographies

V. D. Gorde

Research scholar, Department of pharmaceutical science, Bhagwant University, Ajmer, Rajasthan.

Punit R. Rachh


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How to Cite
Gorde VD, Rachh PR. Review on Teneligliptin: A novel antihyperglycemic agent. JDDT [Internet]. 22Aug.2019 [cited 18Jun.2021];9(4-s):742-7. Available from: