Cytotoxic Anti-Cancer Activity of Certain Thermotropic Liquid Crystalline Poly (Ester-Amides) Containing 2, 6-Bis (Benzylidene)Cyclohexanone Moiety in the Main Chain

  • Kavitha Erra Kalappa
  • N. Ramalakshmi

Abstract

Five thermotropic liquid crystalline poly(ester-amides) were synthesized by polycondensation method. The poly(ester-amides) were synthesized from varying dicarboxylic acids with a common diamine namely 4,4'-diaminobenzene and a common diol namely 2,6-bis(4-hydroxybenzylidene))cyclohexanone. For qualitative characterization, viscosity measurements and solubility data were used for these synthesized poly(ester-amides). The spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR were performed to investigate the microstructural features of these synthesized poly(ester-amides). The thermal phase transition behavior of these poly(ester-amides) were studied by Differential Scanning Calorimetry (DSC) and Hot-stage Optical Polarized Microscopy (HOPM). The degree of crystallinity was assessed by X-ray diffraction (XRD) patterns. Scanning Electron Microscopic (SEM) technique was used to illustrate the morphology of these poly(ester-amides). The copolymer synthesized was subjected into in vitro anti-cancer activity studies against human breast cancer (MCF-7) cell line.


Keywords: Bisbenzylidenecyclohexanone; poly(ester-amides); polycondensation; thermotropic liquid crystalline properties; cytotoxicity, anticancer.

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Author Biographies

Kavitha Erra Kalappa

Post-Graduate and Research Department of Chemistry, Presidency College (Autonomous), Chennai – 600 005, Tamil Nadu, India

N. Ramalakshmi

Post-Graduate and Research Department of Chemistry, Presidency College (Autonomous), Chennai – 600 005, Tamil Nadu, India

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1.
Kalappa KE, Ramalakshmi N. Cytotoxic Anti-Cancer Activity of Certain Thermotropic Liquid Crystalline Poly (Ester-Amides) Containing 2, 6-Bis (Benzylidene)Cyclohexanone Moiety in the Main Chain. JDDT [Internet]. 15Aug.2019 [cited 18Jun.2021];9(4-s):210-23. Available from: https://jddtonline.info/index.php/jddt/article/view/3273