Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone

Authors

  • Jagdish K Arun
  • Dharmajit Pattanayak
  • Ramesh Adepu
  • C.M Hossain
  • B. Shrivastava
  • Ramya Sri Sura

Abstract

In this present study, floating mucoadhesive tablets of Rosiglitazone were formulated to improve the gastric retention time and overall bioavailability. Different mucoadhesive polymers like HPMC K200 M, Na CMC, Carbopol 974P, Karaya gum, Chitosan and Xanthan gum were selected to formulate the tablets. Various formulations were prepared by using these polymers in different concentration. The pre-compression blend of Rosiglitazone mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio and all the results indicated that the blend was having good flow property and hence better compression properties. The swelling studies were performed for the formulations and the results depicted that all the formulations have a good swelling index. The drug release studies depicted that the formulations release the drug in first order. So based on the results, formulation RF13 was found to be an optimized formulation.

Keywords: Mucoadhesive tablets, Rosiglitazone, Bioadhesive polymers.

DOI

https://doi.org/10.22270/jddt.v9i4-s.3267

Published

15-08-2019
Statistics
Abstract Display: 756
PDF Downloads: 674

How to Cite

1.
Arun JK, Pattanayak D, Adepu R, Hossain C, Shrivastava B, Sura RS. Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 12];9(4-s):145-54. Available from: https://jddtonline.info/index.php/jddt/article/view/3267

How to Cite

1.
Arun JK, Pattanayak D, Adepu R, Hossain C, Shrivastava B, Sura RS. Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 12];9(4-s):145-54. Available from: https://jddtonline.info/index.php/jddt/article/view/3267