Formulation and Evaluation of Matrix tablets containing Chitosan Based Polyelectrolyte Complex with Natural Gum for Prolonged Release of Diltiazem HCl
The aim of the present study was to formulate and evaluate the matrix tablets containing chitosan based polyelectrolyte complex microsphers of natural gum to overcome the problem of dose dumping and prolonged release of Diltiazem HCl . Microspheres of diltiazem were prepared using emulsion–crosslinking technique. The prepared microsphers were converted into matrix tablets by direct compression method and evaluated. Interaction of drug with polymers was examined by FT-IR spectroscopy, results indicated absence of chemical interactions between drug and the polymer. Differential Scanning Calorimetry studies indicated amorphous dispersion of Diltiazem HCl particles into the polymer matrix. The %encapsulation efficiencies were found between 36.5% and 84.8%. The average particle size of the prepared microspheres ranged from 9.3 to 16.87 μm when observed under optical microscope using stage micrometer. In-vitro dissolution profiles of all formulations were carried in acidic buffer (pH 1.2) for initial two hours, followed by alkaline buffer (pH 7.4) for 10 h. The drug release was found to be dependent on %encapsulation efficiencies and the concentrations of chitosan and xanthan gum used. The drug release pattern was in accordance with Higuchi’s model for diffusion because, it showed the maximum correlation coefficient in most of the formulations. Further the pre-compression and post-compression parameters for the tablet blend and the compressed tablets were found to be well within the compendial limits and drug release study showed zero order release up to 12 hours.
Keywords: Microspheres, matrix tablets Diltiazem hydrochloride, Chitosan, Xanthan Gum, polyelectrolyte complex, crosslinking.
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