DESIGN, DEVELOPMENT AND CHARACTERIZATION OF KETOROLAC TROMETHAMINE NANOSUSPENSION LOADED IN SITU MUCOADHESIVE OCULAR GEL
Currently, a variety of ophthalmic products illustrate low bioavailability after topical administration because of anatomical and physiological barriers of eye. Ketorolac tromethamine (KT) is a BCS class I, potent anti-inflammatory drug. The rationale of present work was to design and develop KT nanosuspension loaded in situ gel with sustained effect and greater permeability for ocular drug delivery through increased ocular residence time of drug. KT nanosuspension loaded in situ gel was designed by using 32factorial design. Polymers and surfactant were optimized through trial batches exhibiting better drug content (%), In Vitro trans-corneal permeation (%) and corneal hydration (%).Optimized formulation was evaluated for clarity, pH, gelling capacity, rheological behavior, drug content (%), Ex-vivo trans-corneal permeation, corneal hydration, HET CAM assay and physical stability. The resultant formulations revealed optimum viscosity, pH and drug content; as well as higher trans-corneal permeability when compared to the marketed eye drop. Optimized formulation was found as nonirritant to eye with sustained effect and good stability. So, current system can be considered as an efficient ocular drug delivery system for the treatment of postoperative inflammation, which would improve patient compliance and ocular bioavailability.
Keywords: Ketorolac tromethamine, in situ gel, corneal hydration, mucoadhesive, trans-corneal permeability
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