UNNATURAL AMINO ACIDS (UAA’S): A TRENDY SCAFFOLD FOR PHARMACEUTICAL RESEARCH

  • Ajay Singh Bisht Himalaya Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand, India
  • Divya Juyal Himalayan Institute of Pharmacy & Research, Rajawala, dehradun Uttaralhnad, India-248007

Abstract

Unnatural amino acids synthesis is a region of research that has gained a lot of interest in modern years. The accessibility of different synthetic routes for new unnatural amino acid derivatives and related compounds will be a critical point in the designning of novel molecules that impersonate the conformation of the natural, active peptides. These molecules (peptidomimetics) are specially designed to show the high receptor affinity and selectivity with enhanced bioavailability and metabolic stability of the drug molecule. Thus, this review focuses on detailed synthetic methods and analogues leading to synthesize variety of unnatural amino acids including various schemes that includes enantioselective synthesis and microwave-assisted synthesis also.

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Bisht A, Juyal D. UNNATURAL AMINO ACIDS (UAA’S): A TRENDY SCAFFOLD FOR PHARMACEUTICAL RESEARCH. JDDT [Internet]. 15Aug.2019 [cited 14Jun.2021];9(4-s):601-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3210