Formulation and Evaluation of Antifungal Herbal Gel Containing Ethanolic Extract of Senna Alata, Murraya Koenigii and Aloe Vera

Abstract

Herbal medicines is still the mainstay of about 75-80% of the world’s population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with human body and lesser side effects. Herbal medicines consist of plant or its part to treat injuries, disease or illnesses and are used to prevent and treat diseases and ailments or to promote health and healing. it is a drug or preparation made from a plant or plants and used for any to such purpose. The aim of present study was to prepare herbal gel formulation containing ethanolic extract ofantifungal herbal gel containing ethanolic extract of senna alata, murraya koenigi iand aloevera. Topical gel formulation was designed by using ethanolic extract antifungal herbal gel containing ethanolic extract of senna alata, murraya koenigii and aloevera in varied concentrations. The gel was prepared by using carbopol 940(1%w/v),ethanol,propylene glycol, methyl paraben, propyl paraben, edta disodium, tri-ethanolamine and required amount of distilled water. the prepared gels were evaluated for physical appearance, ph, spread ability, drug content, swelling index, diffusion study, viscosity, homogeneity and grittiness. it was inferred from results that gel formulations were good in appearance and homogeneity. Antifungal herbal gel containing ethanolic extract of senna alata, murraya koenigii and aloevera based gel proved to the formula of choice, since it showed the highest percentage of extrudability, good spreadability and rheological properties.

Keywords: Ethanolic extract, Optimization, Rheological properties, Anti fumgal activity.