Nanotechnology Based Approaches For Enhancements of Bioavailability of Sustain Release Formulation

  • Sandip Appasaheb Hapse SPPU, Pune
  • Punit R. Rachh Bhagwant University, Sikar Road, Ajmer, Rajasthan, India


In recent years drug bioavailability has become a subject of matter not only in drug development, additionally within the early stages of drug discovery. Bioavaibility is the major and important pharmacokinetic property of drug. This property of drug is used to describe the fraction of an administered dose of unchanged drug which can reaches to the systemic circulation. When a drug is administered intravenously, its bioavailability is 100%.and if the drug is administered through other routes like oral, its bioavailability decreases because of the incomplete absorption or first pass metabolism. So there is a need in the enhancement of the bioavaibility of sustained release dosage form.This is a consequence of the finding that the majority of candidate drugs that were unsuccessful in clinical trials did so because of problems with absorption, distribution, metabolism, excretion (ADME) and toxicology. Efforts are being created within the Pharmaceutical industry to improve success rates by taking into account the ADME and toxicology aspects in drug discovery. The efficacy of a drug further depends on the ability of the dosage to deliver the active drug to the site of action and at a rate and amount which is sufficient to show the desired pharmacological response. This property is also known as bioavaibility or biologic avaibility.


Download data is not yet available.

Author Biography

Punit R. Rachh, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Bhagwant University, Sikar Road, Ajmer, Rajasthan, India


1. Khan A, Singh L, Various techniques of Bioavailability enhancement: A Review. Journal of Drug Delivery & Therapeutics.2016; 6(3):34-41.
2. Ahmed N, Bioavailability-A Pharmaceutical Review, International Journal of Novel Drug Delivery Technology.2011; 1(1):77-93.
3. Patel J, A Review on Bioavailability And Bioequivalence Trials And Its Necessity. International journal of pharmacy and pharmaceutical science. 2010; 2(3): 1-8.
4. Ratnaparkhi M P Sustained Release Oral Drug Delivery System-An Overview. International Journal of Pharma Research & Review.2013; 2(3):11-21.
5. Srivastav A K, A Review Article on Bioavailability and Bioequivalence Studies. International journal of pharmatechnology.2013; 5(4):1711-1721.
6. Khan M G, Controlled Release Oral Dosage Forms: Some Recent Advances in Matrix Type Drug Delivery Systems. Journal of Medical Sciences. 2010; 1(5): 350-354.
7. Darandale A, Ghule P, Aher A, Narwate B M, Sustained Release Dosage Form- A Concise Review. International Journal of Pharmaceutics & Drug Analysis. 2017; 5(5):153–160
8. Mandhar P, Joshi G, Development of Sustained Release Drug Delivery System- A Review. Asian Pacific Journal of Health Science. 2015; 2(1):179-185.
9. Karvekar M, Khan AB, A Brief Review on Sustained Release Matrix Type Drug Delivery System. Journal of Pharmaceutical Research.2017;16(3):282-289
10. Mehta A, Jain N, Grobler A, Vandana B, Role of Novel Drug Delivery Systems in Bioavailability Enhancement- At A Glance. International Journal of Drug Delivery Technology. 2016; 6(1): 7-26
11. Megaji S, Thota A, Advancements in novel drug delivery systems and Opportunities for Indian Pharmaceutical companies- Research &Reviews. Journal of Pharmaceutics and Nanotechnology.2015; 4(1):2347-7849.
12. Eggleton J, Thomas K V, A review of factors affecting the release an bioavailability of contaminants during sediment disturbance events. International Environment.2004; 30(7):973-980
13. Chaudhary A, Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research. 2012; 2 (1):32-67.
14. Thakkar H, Patel B, Thakkar S A Review on Techniques for Oral Bioavailability Enhancement of Drugs. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4(3):203-223
15. Baig MR, Shahiwala A. Sensible Use of Technologies to Increase Solubility and Bioavailability in Formulation Development. Advancements in Bioequivalence & Bioavailability.2018; 1(1):1-4.
16. Akhtar A, Enhanced bioavaibility of drugs via intranasal drug delivery system. International research journal of Pharmacy. 2012: 3(7):68-74.
17. Mehta A, Jain N, Grobler A, Vandana B, Role of Novel Drug Delivery Systems in Bioavailability Enhancement- At A Glance. International Journal of Drug Delivery Technology. 2016; 6(1):7-26
18. Sharma M, Sharma R, Jain D K, Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs, Scientifica.2016; 2016:1-11
19. Nakarani M, Misra A K, Patel, Vaghani S S, Itraconazole Nano suspension for oral delivery-Formulation, characterization and in vitro comparison with marketed formulation.Drau.2010; 18:84-90.
20. Jadhav TR, Review on Lyophilization technique. World journal of pharmacy and pharmaceutical sciences.2015; 4(05): 1906-1928.
21. Jain MS, Spray Drying in Pharmaceutical Industry-A Review. Research Journal of pharmaceutical dosage forms and technology .2011; 4(2): 74-79.
22. Pal S L, Jana U, Manna P K, Mohanta G P, Manavalan R, Nanoparticle- An overview of preparation and characterization. Journal of Applied Pharmaceutical Science. 2011;1(6):228-234
23. Kamboj S, Saini V, Maggon N, Bala S, Jhawat VC, Novel Vesicular Drug Carriers for Bioavailability Enhancement. International journal of pharmacy. 2013; 22:92-97
24. Gupta S, Kesarla R, Omri A, Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics, 2013; 2013:1-16.
25. Makkar D, Solid lipid nanoparticles: a comprehensive review. Journal of Chemical and Pharmaceutical Research.2016; 8(8):102-114.
26. Eldhose, Transfersomes – A Review. International journal of pharmacy and pharmaceutical Research. 2016; 6(4):1-17.
27. Heera P, Nanoparticle Characterization and Application: An Overview. International Journal of current microbiology and applied Science.2015; 4(8):379-386.
137 Views | 181 Downloads
How to Cite
Hapse S, Rachh PR. Nanotechnology Based Approaches For Enhancements of Bioavailability of Sustain Release Formulation. JDDT [Internet]. 15May2019 [cited 18May2021];9(3):617-25. Available from: