Sublingual route for systemic drug delivery
Abstract
Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in geriatric, pediatric and psychiatric patients with dysphagia. Sublingual drug delivery shows fast therapeutic action than orally ingested drugs with fewer side effects. This review highlights advantages, disadvantages, different sublingual Gland, sublingual formulation such as tablets, films drops, sprays etc, evaluation parameters.
Keywords: Sublingual delivery, dysphagia, sublingual gland, improved bioavailability, evaluations.
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References
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2. Singh B, Gupta S, Kumar A, Fabrication and evaluation of sublingual tablets of telmisartan using different superdisintegrants: formulation and evaluation, International Journal of Pharmacy and Pharmaceutical Research, 2015; 3(1):201-218.
3. Pawar PP, Gaikwad SS, Patil PB, Design and development of sublingual tablets of ondansetron hydrochloride: formulation and evaluation, World Journal of Pharmacy and Pharmaceutical Sciences, 2016; 5(12):733-745.
4. Shah S, Badola A, Kothiyal P, Sublingual tablets an overview: A pharmaceuitical review, Indian Journal of Pharmaceutical and Biological Research, 2016; 4(2):20-26.
5. Singh M, Chitranshi N, Singh AP, Arora V, Siddiqi AW, An overview on fast disintegrating sublingual tablets: A pharmaceuitical review International Journal of drug delivery, 2012; 4(4):407-417.
6. Narang N, Sharma J, Sublingual mucosa as a route for systemic drug delivery: A pharmaceuitical review, International Journal of Pharmacy and Pharmaceutical Sciences, 2011; 3(2):18-22.
7. Patel P, Makwana S, Jobanputra U et al, Sublingual route for systemic delivery of ondansetron: A pharmaceuitical review, International Journal of Drug Development and Research, 2011; 3(4):36-40.
8. Sarkhejiya NA, Patel VP, Pandya DJ, Sublingual delivery A promising approach to improve bioavailability: A pharmaceuitical review, Pharma Sciences an International Journal of Pharmaceutical Sciences, 2013; 4(2):3870-3889.
9. Kavitha K, Subramaniam K, Hui BJ, et al, Potential drug candidate for fast dissolving drug delivery: A pharmaceuitical review, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2013; 4(4):1510-1526.
10. Vilayat AS, Mohammad A, Considerations in developing sublingual tablets: A pharmaceuitical review, PharmTech Advancing Development and Manufacturing, 2014; 38(11).
11. Patel KN, Pancholi SS, Sublingual route for systemic drug delivery: A pharmaceuitical review, International Journal of Research in Pharmaceutical and biomedical Sciences, 2012; 3(2):913-923.
12. Arya A, Chandra A, Sharma V, Pathak K, Fast dissolving oral film an innovative drug delivery system and dosage form: A pharmaceuitical review, International Journal of ChemTech Research, 2010; 2(1):576-583.
13. Kapadia YD, Sodha HP, Patel VP, Formulation development and evaluation of sublingual film of asenapine maleate: formulation and evaluation, Pharma Science Monitor an international Journal of Pharmaceutical Science, 2013; 4(3):190-209.
14. Siddiqui N, Garg G, Sharma PK, A novel approach in oral fast dissolving drug delivery system and their patents: A pharmaceuitical review, Advances in Biological research, 2011; 5(6):291-303.
15. Lachman L, Liebermann HA, Kanig JL.The Theory and Practice of Industrial Pharmacy, 3rd ed. Mumbai: Varghese Publishing House1990. P. 479-488.
16. Indian Pharmacopoeia, Controller of publications, Govt. of India Ministry of health and family welfare, New Delhi, 1996. P. A-147.
17. United State Pharmacopoeia 30NF25, the official compendia of standards, Asian edition, United States Pharmacopoeial convection Inc. Rockville MD 2009. P. 276-383,617-658,806-807,817, 1764, 2492-2495.
18. Pethe AM, Salunkhe SP, Formulation and evaluation of mucoadhesive buccal tablet of simvastatin: formulation and evaluation, International Journal of Pharma and Bio Science, 2014, 5(3), 268-278.
19. Deshmukh G, Ruikar D, Seth AK et al, Formulation and development of lamotrigine fast disintegrating tablet: formulation and evaluation, Pharma Science Monitor an International Journal of Pharmaceutical Sciences, 2011; 2(2):S7-S15.
20. Nagar P, Singh K, Chauhan I et al, Orally disintegrating tablets: Formulation, preparation techniques and evaluation: A pharmaceutical review, Journal of Applied Pharamaceutical Science, 2011; 1(4):35-45.
21. Gaikwad SS, Jadhav AA, Chavan MK et al, Design and In-vitro evaluation of sublingual tablets of timolol maleate: formulation and evaluation, Bentham Science Applied clinical Research, Clinical Trials and Regulatory Affairs, 2016; 3(1):56-63.
22. Senthil A, Navinchandra CP, Jose J, Mahim MM, Ravajibhai SY. Preparation and evaluation of timolol maleate mucoadhesive buccal tablets: formulation and evaluation, International Research Journal of Pharmacy, 2012; 3(3):292-297.
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Pawar PP, Ghorpade HS, Kokane BA. Sublingual route for systemic drug delivery. JDDT [Internet]. 15Dec.2018 [cited 18Apr.2024];8(6-s):340-3. Available from: https://jddtonline.info/index.php/jddt/article/view/2097
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