• Suseela Lanka Department of Biotechnology Krishna University, Machilipatnam-521001, Andhra Pradesh, India


Aloe vera, a succulent plant that grows in arid and subtropical climates is best known for its medicinal properties and is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine. It has been in use for a long time by people of varied cultures and traditional uses include applications to reduce perspiration, oral dosing for diabetes and to get rid of a range of gastrointestinal ailments. It is also used to treat burn wounds, minor cuts, genital herpes, and seborrheic dermatitis. The leaves of this wonderful medicinal plant contain numerous vitamins, minerals, natural sugars, enzymes, amino acids, and as well rich in various bioactive compounds that exhibit emollient, purgative, anti-inflammatory, antioxidant, antimicrobial, anti-helmenthic, antifungal, aphrodisiac, antiseptic and cosmetic values. Many cosmetic industries widely use this plant owing to its healing and nourishing properties. 

Keywords: Aloe vera, Medicinal Uses, bioactive compounds, Cosmetic industries


Download data is not yet available.

Author Biography

Suseela Lanka, Department of Biotechnology Krishna University, Machilipatnam-521001, Andhra Pradesh, India

Department of Biotechnology Krishna University, Machilipatnam-521001, Andhra Pradesh, India


1. Mothana RA and Linclequist V. Antimicrobial Activity of Some Medicinal Plants of the Island Soqotra. Journal of Ethnopharmacology 2005; 96:177-181.
2. Santos PRV, Oliveria ACX, Tomassini TCB. Controls Microbiological Products Fitoterapices. Revista de Farmácia e Bioquímica 1995; 31:35-38.
3. Joshi SP. Chemical Constituents and Biological Activity of Aloe barbadensis—A Review. Journal of Medicinal and Aromatic Plant Science 1997; 20:768-773.
4. West DP and Zhu YF. Evaluation of Aloe vera Gel Gloves in the Treatment of Dry Skin Associated with Occupational Exposure. American Journal of Infection Control 2003; 31:40-42.
5. Yagi A, Kabash A, Mizuno K, Moustafa SM, Khalifa TI, Tsuji H. Radical Scavenging Glycoprotein Inhibiting Cyclooxygenase-2 and Thromboxane A2 Synthase from Aloe vera Gel. Planta Medica 2003; 69:269-271.
6. African Pharmacopoeia, Vol. 1, Organization of African Unity, Scientific, Technical & Research Commission, Lagos, 1985.
7. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes. Diabetes Care 2003; 26:1277-1294.
8. Marshall JM. Aloe vera gel: What is the evidence? Pharma Jr 1990; 24:360–2.
9. Davis RH. Aloe vera: A scientific approach. New York: Vantage Press Inc. 1997; 290-306.
10. Ghazanfer SA. Handbook of Arabian Medicinal Plants. Boca Raton, FL, CRC Press. 1994; 263pp.
11. Heber D. Physicians’ Desk Reference for Herbal Medicines. Thomson Health Care, Montvale. 4th Ed. 2007:515-518.
12. Atherton P. Aloe vera revisited. British Journal of Phytotherapy 1998; 4:76–83.
13. Shelton M. Aloe vera, its chemical and therapeutic properties. International Journal of Dermatology 1991; 30:679–83.
14. Atherton P. The essential Aloe vera: The actions and the evidence. 2nd ed. 1997.
15. Sato Y, Ohta S, Shinoda M. Studies on chemical protectors against radiation XXXI: Protective effects of Aloe arborescens on skin injury induced by x-irradiation. Yakugaku Zasshi 1990; 110:876–84.
16. Byeon S, Pelley R, Ullrich SE, Waller TA, Bucana CD, Strickland FM. Aloe barbadensis extracts reduces the production of Interleukin-10 after exposure to ultraviolet radiation. Journal of Investigative Dermatology 1988; 110:811–7.
17. Hutter JA, Salmon M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, et al. Anti-inflammatory C-glucosyl chromone from Aloe barbadensis. Journal of Natural Products 1996; 59:541–3.
18. Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Alimentary pharmacology & therapeutics 2004; 19:521-527.
19. Reuter J, Jocher A, Stump J, Grossjohann B, Franke G, Schempp CM. Investigation of the anti inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin pharmacology and physiology 2008; 21:106-110.
20. Lee YS, Ju HK, Kim YJ, Lim TG, Uddin MR, Kim YB, Baek JH, Kwon SW, Lee KW, Seo HS, Park SU. Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation. PloS one 2013; 8:e82479.
21. Borra SK, Lagisetty RK, Mallela GR. Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats. African Journal of Pharmacy and Pharmacology 2011; 5:1867-1871.
22. Ro JY, Lee B, Kim JY, Chung Y, Chung MH, Lee SK, et al. Inhibitory mechanism of aloe single component (Alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions. Journal of Pharmacology and Experimental Therapeutics 2000; 292:114–21.
23. Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D. Decreased mortality of Norman murine sarcoma in mice treated with the Immunomodulator, Acemannon. Molecular Biotherapy 1991; 3:79–87.
24. Hart LA, Nibbering PH, van den Barselaar MT, van Dijk H, van den Burg AJ, Labadie RP. Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils. International Journal of Immunopharmacology. 1990; 12:427–34.
25. Madan J, Sharma A, Inamdar N, Rao H, Singh R. Immunomodulatory properties of Aloe vera gel in mice. International journal of green Pharmacy. 2008; 2(3):152.
26. Im SA, Oh ST, Song S, Kim MR, Kim DS, Woo SS, Jo TH, Park YI, Lee CK. Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. International Journal of immunopharmacology 2005; 5(2):271-279.
27. Zhang XF, Wang HM, Song YL, Nie LH, Wang LF, Liu B, Shen PP, Liu Y. Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorganic & medicinal chemistry letters 2006; 16(4):949-53.
28. Ishii Y, Tanizawa H, Takino Y. Studies of Aloe. V: Mechanism of cathartic effect. Biological and Pharmaceutical Bulletin. 1994; 17:651–3.
29. Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN. Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrobial Agents and Chemotherapy 1991; 35:2463–6.
30. Kim HS, Lee BM. Inhibition of benzo [a] pyrene-DNA adduct formation by Aloe barbadensis Miller. Carcinogenesis 1997; 18:771–6.
31. Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum, and Coriolus vesicolor) Carcinogenesis 1999; 20:1637–40.
32. Saini MR, Goyal PK, Chaudhary G. Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice. Journal of Environmental Pathology, Toxicology and Oncology 2010; 29:127-35.
33. El-Shemy HA, Aboul-Soud MA,Nassr-Allah AA, Aboul-Enein KM, Kabash A, Yagi A. Antitumor properties and modulation of antioxidant enzymes activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction. Current medicinal chemistry 2010; 17:129-138.
34. Bajwa R, Shafique S, Shafique S. Appraisal of antifungal activity of Aloe vera. Mycopath 2007; 5:5-9.
35. Sitara U, Hassan N, Naseem J.Antifungal activity of Aloe vera gel against plant pathogenic fungi. Pakistan Journal of Botany 2011; 43:2231-2233.
36. Nidiry ES, Ganeshan G, Lokesha AN. Antifungal activity of some extractives and constituents of Aloe vera. Research Journal of Medicinal Plants 2011; 5:196-200.
37. Lawrence R, Tripathi P, Jeyakumar E. Isolation, purification and evaluation of antibacterial agents from Aloe vera. Brazilian Journal of Microbiology 2009 40:906-915.
38. Cock IE. Antimicrobial activity of Aloe barbadensis Miller leaf gel components. The Internet Journal of Microbiology 2008; 4(2):17.
39. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian Journal of Dermatology 2008; 53:163–6.
40. Chithra R Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Molecular and Cellular Biochemistry 1998; 181:71–6.
41. Heggers J, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, et al. Beneficial effect of Aloe on wound healing in an excisional wound model. Journal of Alternative and Complementary Medicine 1996; 2:271–7.
42. Chithra P, Sajithlal G, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. Journal of Ethnopharmacology 1998; 59:179–86.
43. Atiba A, Ueno H, Uzuka Y. The effect of Aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats. Journal of Veterinary Medical Science 2011; 73:583–589.
44. Seyyed Abbas Hashemi, Seyyed Abdollah Madani, and Saied Abediankenari. The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds. BioMed Research International 2015; (2015), Article ID 714216, 6 pages.
45. Rajput SS, Soni KK, Saxena RC. Pharmacology and phytochemistry of saponin isolated from Aloe vera for wound healing activity. Asian Journal of Chemistry 2009; 21:1029.
46. Roberts DB, Travis EL. Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice. International Journal of Radiation Oncology Biology Physics 1995; 32:1047–52.
47. Garnick JJ, Singh B, Winkley G. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous ulcers. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology. 1998; 86:550–6.
48. Hayes SM. Lichen planus—Report of successful treatment with Aloe vera. General Dentistry 1999; 47:268–72.
49. Mansourian A, Momen-Heravi F, Saheb-Jamee M. Comparison of treatment efficacy of daily use of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: A randomized double-blinded clinical trial. The American Journal of the Medical Sciences 2011; 342:447–51.
50. Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. The efficacy of Aloe vera gel in the treatment of oral lichen planus: A randomized controlled trial. British Journal of Dermatology 2008; 158:573–7.
51. Salazar-Sanchez N, Lopez-Jornet P, Camacho-Alonso F, Sanchez-Siles M. Efficacy of topical Aloe vera in patients with oral lichen planus: A randomized double-blind study. Journal of Oral Pathology and Medicine 2010; 39:735–40.
52. PDR for herbal medicines. Montvale NJ. Medical Economics Company; 1st ed. 1998; p. 631.
53. Krinsky DL, Hawkins EB, Pelton R, Willis NA, La-valle JB. Natural therapeutics pocket guide. 2nd ed. Cleveland: Lexi-Comp, Inc; 2003; p. 379.
54. George D, Bhat SS, Antony B. Comparative evaluation of the antimicrobial efficacy of Aloe vera tooth gel and two popular commercial toothpastes: An in vitro study. General Dentistry 2009; 57:238–41.
55. Wynn RL. Aloe vera gel: Update for dentistry. General Dentistry 2005; 53(1): 6-9.
56. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. Journal of Medicinal food. 2004; 7:61-66.
57. Beppu H, Shimpo K, Chihara T, Kaneko T, Tamai I, Yamaji S, Ozaki S, Kuzuya H, Sonoda S. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple lowdose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. Journal of ethnopharmacology 2006; 103:468-477.
58. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clinical and Experimental Pharmacology and Physiology 2006; 33:232-237.
59. Lee KY, Weintraub ST, Yu BP. Isolation and identification of a phenolic antioxidant from Aloe barbadensis. Free radical biology and medicine 2000; 28:261-5.
60. Ahlawat KS, Khatkar BS. Processing, food applications and safety of Aloe vera products: a review. Journal of food science and technology 2011; 48:525-33.
61. Eshun K, He Q. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries—a review. Critical reviews in food science and nutrition 2004; 44:91-96.
62. Sanghi SB. Aloe vera: A medicinal herb. International Journal of Re¬search-Granthaalayah. 2015; 3(11):32‒34.
63. Shireen F, Manipal S, Prabu D. Anti-fungal activity of Aloe vera: In vitro study. SRM Journal of Research in Dental Science. 2015; 6:92-95.
64. Amit P, Shweta S. Aloe Vera: A Systematic Review of its Industrial and Ethno-Medicinal Efficacy. International Journal of Pharmaceutical Research & Allied Sciences. 2016; 5(1):21-33.
65. Sushen U, Unnithan CR, Swamy Rajan, Rajan Chouhan, Sushma Chouhan, Fasi Uddin and Kowsalya R. Aloe vera: a potential herb used as traditional medicine by tribal people of Kondagatu and Purudu of Karimnagar District, Telangana state, India. and their preparative methods. European Journal of Pharmaceutical and Medical Research 2017; 4(7):820-831.
66. Tsegaye M, Moges S, Misretaw G. Review on Therapeutic Uses of Aloe Vera. Global Journal of Pharmacology. 2017; 11(2): 14-20.
67. Sandeep Kumar Y. Medicinal and Cosmetics Uses of Aloe Vera: A Review. International Advanced Research Journal in Science, Engineering and Technology. 2017; 4(7):226-127.
68. Amin K, Senay O, Zeliha S. Aloe Vera: a miracle plant with its wide-ranging applications. Pharmacy & Pharmacology International Journal. 2018; 6(1):1-2.
69. Yohannes G. review on medicinal value of Aloe vera in veterinary practice. Biomedical Journal of Scientific and Technical Research, 2018; 6(1):1-6.
5529 Views | 2835 Downloads
How to Cite
Lanka S. A REVIEW ON ALOE VERA-THE WONDER MEDICINAL PLANT. JDDT [Internet]. 15Oct.2018 [cited 18May2024];8(5-s):94-9. Available from: https://jddtonline.info/index.php/jddt/article/view/1962