STUDY ON ANTICANCER EFFECT OF SYNTHETIC BIOGENIC SOURCE OF GERMACRENE A
Objective: Based on obtaining germacrene A, which is the analogue of synthetic β-elemene, by means of synthetic biology，this experiment aims to explore the anti-tumor effect of germacrene A.
Results: After administration, the volume of T24 cells was significantly reduced. The shape of the T24 cells gradually changed from wedge-shaped and polygonal to round, and the T24 cells soon fell off, atrophied and disintegrated. After Tet blue staining, a large number of T24 cells after administration were observed to be dead; It was found by means of MTT assay that T24 cells were inhibited to varying degrees by the effects of different concentrations of germacrene A.
Conclusion: The above experimental results show that the synthetic biological source of germacrene A has obvious inhibitory effect on bladder cancer T24 cells, and this effect has obvious time and concentration dependence.
Keywords：Germacrene A; Synthetic drugs; Antitumor; β-elemene
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