SOLID AS SOLVENT: NOVEL SPECTROPHOTOMETRIC ANALYTICAL TECHNIQUE FOR QUANTITATIVE ESTIMATION OF TINIDAZOLE IN TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND LIGNOCAINE HYDROCHLORIDE) AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)
Abstract
As per the mixed solvency concept, every substance present in this universe has got solubilizing power. The substance may be a gas, liquid or solid. The present research work is an attempt to demonstrate the solubilizing property of solids. Also, the present research work is one of the examples which prove that solids can also be employed for spectrophotometric analysis of poorly soluble drugs in place of organic solvents. Tinidazole has got poor solubility in distilled water, while, significantly high solubility in a eutectic liquid of two solids, namely, phenol and lignocaine hydrochloride. Phenol and lignocaine hydrochloride were employed in 4:1 ratio to give eutectic liquid (PL 41). This eutectic liquid was employed to act as solvent to extract out the drug, tinidazole, from the fine powder of its tablets for spectrophotometric estimation at 318 nm. Necessary dilutions were done using distilled water. The solubility of tinidazole in distilled water is 5.38 mg/ml at room temperature while the approximate solubility in PL 41 is more than 200 mg/ml. Proposed method is novel, accurate, rapid and free from toxicity of organic solvents and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the analytical method employed. Tablet excipients together with phenol and lignocaine hydrochloride did not interfere at 318 nm.
Keywords - Spectrophotometric analysis, mixed-solvency concept, tinidazole, phenol – lignocaine hydrochloride eutectic liquid
DOI
https://doi.org/10.22270/jddt.v7i3.1437References
Maheshwari RK, “Mixed-Solvency Approach”- Boon for Solubilization of Poorly Soluble Drugs, Asian Journal of Pharmaceutics 2010; Jan-March, 60-63.
Maheshwari RK, Solubilization of Ibuprofen by Mixed Solvency Approach, The Indian Pharmacist, 2009; 8(87):81-84.
Maheshwari RK, “Mixed-Solvency” – A Novel Concept for Solubilization of Poorly Water-Soluble Drugs, Delving J. Tech. Eng. Sci., 2009; 1(1):39-43.
Maheshwari RK, “Solid as Solvent”, Novel Spectrophotometric Analysis of Satranidazole Tablets using Phenol as Solvent, The Indian Pharmacist, 2014; vol. XII, 37-40.
Maheshwari RK, Potentiation of Solvent Character by Mixed Solvency Concept: A Novel Concept of Solubilization, Journal of Pharmacy Research, 2010; 3(2):411-413.
Maheshwari RK, “Solid as Solvent”-Novel Spectrophotometric Analysis of Tinidazole, Tablets using Melted Phenol as Solvent, Asian Journal of Pharmaceutical Research, 2015; 5(1):21-24.
Maheshwari RK, Shilpkar R, Formulation Development and Evaluation of Injection of Poorly Soluble Drug using Mixed Solvency Concept, International Journal of Pharma and Biosciences, 2012; 3(1):179-189.
Maheshwari RK, Rajagopalan R, Formulation and Evaluation of Paracetamol Syrup Made by Mixed-Solvency Concept, Der Pharmacia Lettre, 2012; 4(1):170-174.
Soni LK, Solanki SS, Maheshwari RK, Solubilization of Poorly Water Soluble Drug using Mixed Solvency Approach for Aqueous Injection, British Journal of Pharmaceutical Research, 2014; 4(5):549-568
Maheshwari RK, Karawande UV, Application of Novel Concept of Mixed Solvency in the Design and Development of Floating Microspheres of Furosemide, International journal of Pharmacy and Pharmaceutical Sciences, 2013; 15:167-195.
Maheshwari RK, Chaklan N, Singh S, Novel Pharmaceutical Application of Mixed Solvency Concept for Development of Solid Dispersions of Piroxicam, European Journal of Biomedical and Pharmaceutical Sciences, 2015; 1(3):578-591.
Agrawal A, Maheshwari RK, Formulation Development and Evaluation of In-situ Nasal Gel of Poorly Water Soluble Drug using Mixed Solvency Concept, Asian Journal of Pharmaceutics, 2011; 5(3):131-140.
Prashant B, Rawat S, Mahajan YY, Galgatte UC, Maheshwari RK, Formulation Development and Evaluation of Aqueous Injection of Poorly Soluble Drug Made by Novel Application of Mixed Solvency Concept, International Journal of Drug Delivery, 2013; 2:152-166.
Maheshwari Y, Mishra DK, Mahajan SC, Maheshwari P, Maheshwari RK, J. Jain, Novel Pharmaceutical Application of Mixed Solvency in the Formulation Development of Syrups (Liquid Oral Solutions) of Poorly Water-Soluble Drugs, International Journal of Pharmacy, 2013; 3(4):753-758.
Chandna C, Maheshwari RK, Mixed Solvency Concept in Reducing Surfactant Concentration of Self Emulsifying Drug Delivery Systems of Candesartan cilexetil using D-optimal Mixture Design, Asian Journal of Pharmaceutics 2013, April-June issue, 83-91.
Maheshwari RK, Rajagopalan R, Formulation and Evaluation of Tinidazole Syrup Made by Mixed-Solvency Concept, Der Pharmacia Lettre 2011; 3(6):266-271.
Soni LK, Solanki SS, Maheshwari RK, Studies on Mixed Solvency Concept in Formulation Development of Oral Solution (Syrup) of Poorly Water Soluble Drug, Journal of Harmonized Research in Pharmacy 2015; 4(4):305-315.
Maheshwari RK, Fouzdar A, “Solid as Solvent”-Novel Approach for Spectrophotometric Estimation of Solid Dosage Form of Nalidixic Acid using Solids (Eutectic Liquid of Phenol and Niacinamide) as Solubilizing Agents (Mixed Solvency Concept), European Journal of Biomedical and Pharmaceutical Sciences, 2014; 1(3):424-430.
Maheshwari RK, Jain R, George P, Formulation Development and Evaluation of Controlled Release Tablets of Lamotrigine using Mixed Solvency Concept, Bulletin of Pharmaceutical Research, 2015; 5(1):14-19.
Maheshwari RK, “Solid as Solvent”- Novel Spectophotometric Analysis of Norfloxacin Tablets using Phenol as Solvent”, International Journal of Current Pharmaceutical Research, 2014; 6:76-78.
Maheshwari RK, Upadhyay N, Jain J, Patani M, Mathuria KC, New Spectrophotometric Estimation of Naproxen Tablet Formulation Employing Mixed Solvency Concept (at 331 nm), International Journal of Pharmacy and Technology, 2011; 3(4): 3618-3623.
Maheshwari RK, Gupta S, Gharia A, Garg SK, Shilpkar R, Simple Eco-friendly Spectrophotometric Estimation of Tinidazole Tablets by Application of Mixed-Solvency Technique, Bulletin of Pharmaceutical Research, 2011; 1(1):22-25.
Bhawsar N, Maheshwari RK, Ansari A, Saktawat Y, New Spectrophotometric Estimation of Gatifloxacin in the Tablets using Mixed Solvency Approach, International Journal of Pharmaceutical Science, 2011; 2(2):270-274.
Maheshwari RK, Upadhyay N, Jain J, Patani M, Pandey R, New Spectrophotometric Analysis of Gatifloxacin Tablets Utilizing Mixed Solvency Concept (at 288 nm), Der Pharmacia Lettre, 2012; 4(1):1-4.
Sreegiriprasad B, Gupta MV, Devanna N, Ramadevi M, Vishnuvarethanrao G, Mixed Solvency Concept: A Promising Tool to Enhance Solubility of Poorly Soluble Drug Aceclofenac, International Journal of Pharmaceutical Chemical and Biological Sciences, 2012; 3:338-342.
Vijayranga G, Deveswaran R, Bharath S, Basavraj BV, Madhavan V, Development of an Analytical Method for Spectrophotometric Estimation of Ketoprofen using Mixed Solvency Approach, International Journal of Pharmaceutical Sciences and Research, 2012, 4, 1053-1056.
Maheshwari RK, “Solid as Solvent”-Novel Spectrophotometric Analysis of Frusemide Tablets using Phenol as Solvent, Bulletin of Pharmaceutical Research, 2014; 4(2):104-107.
Maheshwari RK, Putliwala M, Padiyar A, Novel Approach for Spectrophotometric Estimation of Naproxen in Tablet Dosage Form using Solids (Eutectic Liquid of Phenol and Niacinamide) as Solubilizing Agent (Mixed Solvency Concept), Asian Journal of Pharmaceutical Research, 2015; 5(1):25-28.
Maheshwari RK, Padiyar A, Putliwala M, Utilization of Mixed Solvency Technique in Spectrophotometric Analysis of Cefixime Trihydrate Tablets, International Journal of Pharmaceutical Research and Analysis, 2015, 5(1), 01-03.
Maheshwari RK, Khan MA, Maheshwari N, “Solid as Solvent”-Novel Spectrophotometric Analytical Method for Metronidazole Tablets using Solids (Eutectic Liquid of Phenol and Niacinamide) as Solubilizing Agents (Mixed Solvency Concept), Research Journal of Pharmacy and Technology, 2016; 9(6):705-708.
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