NANOSUSPENSION TECHNOLOGY: A INNOVATIVE SLANT FOR DRUG DELIVERY SYSTEM AND PERMEABILITY ENHANCER FOR POORLY WATER SOLUBLE DRUGS

  • Dhiren P. Shah Principal, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
  • Bhavesh Patel Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
  • Chainesh Shah Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.

Abstract

Nanosuspension contains submicron colloidal dispersion of pharmaceutical active ingredient particles in a liquid phase stabilized by surfactants. The poor water solubility of drugs is major problem for drug formulation. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate, bioavailability as well as improve stability. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Nanosuspension many attempts have been made to deliver poorly water soluble drugs as a nanosuspension prepared by adopting various methods. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspension. Recently, the engineering of nanosuspension employing emulsions and microemulsion as templates. The unique features of nanosuspension have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels, parenteral, peroral, ocular and pulmonary routes.

Keywords: Nanosuspension, Solubility enhancement, Saturation solubility, Homogenization.

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Author Biographies

Dhiren P. Shah, Principal, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
Principal, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
Bhavesh Patel, Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
M. Pharm, Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.
Chainesh Shah, Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.

Assistant Professor, Dept. of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Umrakh- 394345, Bardoli, Gujarat.

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How to Cite
1.
Shah D, Patel B, Shah C. NANOSUSPENSION TECHNOLOGY: A INNOVATIVE SLANT FOR DRUG DELIVERY SYSTEM AND PERMEABILITY ENHANCER FOR POORLY WATER SOLUBLE DRUGS. JDDT [Internet]. 13Jan.2015 [cited 27Nov.2021];5(1):10-3. Available from: http://jddtonline.info/index.php/jddt/article/view/995