SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM- A NOVALAPPROACH FOR IMPROVING BIOAVAILABILITY

  • Seema Gautam Devsthali vidyapeeth college of pharmacy lalpur.rudrapur ( uttarakhand)
  • Arun Kumar Singh Devsthali vidyapeeth college of pharmacy lalpur.rudrapur ( uttarakhand)

Abstract

The primary object of self-nanoemulsifying drug delivery system (SNEDDS) is to enhance the oral bioavailability of poorly  water soluble drugs.The major problem in oral formulations is low and erratic bioavailability, which mainly results due to poor aqueous solubility of active constituents. Among various approach SNEDDS has gained more attention due to enhanced oral bio-availability enabling reduction in dose. Nano-emulsions can be easily fabricated by low-energy emulsification methods, such as the phase inversion ,temperature method and phase inversion composition method. SNEDDS are anhydrous homogenous liquid mixtures consisting of oil, surfactant, drug and co-emulsifier or solubilizer, which spontaneously form oil-in-water nanoemulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring.

Keywords: Self emulsifying drug delivery system, surfactant, co-surfactant.

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Author Biographies

Seema Gautam, Devsthali vidyapeeth college of pharmacy lalpur.rudrapur ( uttarakhand)
M.pharm Research Scholar.
Arun Kumar Singh, Devsthali vidyapeeth college of pharmacy lalpur.rudrapur ( uttarakhand)
M.pharm Research Scholar.
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How to Cite
1.
Gautam S, Singh A. SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM- A NOVALAPPROACH FOR IMPROVING BIOAVAILABILITY. JDDT [Internet]. 15Nov.2014 [cited 18Feb.2020];4(6):33-8. Available from: http://jddtonline.info/index.php/jddt/article/view/989