PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE

  • Anup Naha Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Kiran Sai Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Ikya Rai Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Bhavisha Vora Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Apoorva D Reddy Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • P Kartika Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India

Abstract

Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated for its particle size, drug content and in vitro dissolution studies. The above mentioned method showed similar particle size and exhibited an improvement in the drug entrapment efficiency. The ultraviolet spectrophotometric method was used to analyze Glibenclamide at 300 nm in different buffers. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Glibenclamide.

Keywords: Glibenclamide, polymeric nanoparticles, solvent evaporation

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How to Cite
Naha, A., Sai, K., Rai, I., Vora, B., Reddy, A., & Kartika, P. (2014). PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE. Journal of Drug Delivery and Therapeutics, 4(5), 190-192. https://doi.org/10.22270/jddt.v4i5.982