COMPARATIVE EFFICACY OF GABAPENTIN A CONVENTIONAL ANTICONVULSANT WITH CONVENTIONAL ANALGESIC TREMADOL IN VISCERAL PAIN MODEL OF RODENTS
Carabmazepine is an established drug for trigeminal neuralgia while gabapentin has been tried in postoperative pain but its effectiveness in visceral pain and when compared to conventional analgesics needs to be evaluated.The present study was planned to study the analgesic effects of gabapentin in animal pain model of visceral nociception like writhing test and to compare it with conventional analgesic tremadol. This study has been carried out for evaluation of role of gabapentin in visceral nociception in mice . In the writhing test, a significant reduction in number of writhes have been observed in pretreated groups of mice reflects antinociceptive efficacy of gabapentin in acetic acid induced visceral nociception
ÂKey Words- writhing test, visceral nociception, tremadol, gabapentin
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