A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS

  • P R Patil
  • M A Chaudhari
  • P V Sapkale
  • Surajj Sarode
  • Rageeb Md. Usman

Abstract

5-HT neurotransmission system is targeted by drugs useful in behavioural disorders, including anxiety, depression, psychosis and eating disorders. 5-HT1A autoreceptors, located on 5-HT neurones of the midbrain raphe nuclei, are coupled to K channels through a pertusis toxin-sensitive G-protein. 5-HT1A receptor agonists inhibit adenylyl cyclase, while 5-HT2C receptor agonists activate two signal transduction pathways coupled with these receptors. 5-HT1A and 5-HT2C receptors have lots potential in treating the disorders with less or no side effects.

Keywords: 5-HT1A, 5-HT2C, Receptor.

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1.
Patil P, Chaudhari M, Sapkale P, Sarode S, Usman R. A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS. JDDT [Internet]. 14Sep.2014 [cited 22Feb.2020];4(5):55-7. Available from: http://jddtonline.info/index.php/jddt/article/view/975