HISTOPATHOLOGICAL EXAMINATION OF CONJUNCTIVAL SCRAPPING â€“ AN OBJECTIVE METHOD TO KNOW THE EFFICACY OF DRUG IN VERNAL KERATO CONJUNCTIVITIS
The study aims to test the efficiency of FML and Azelastine in the treatment ofÂ vernal kerato conjunctivitisÂ by objective method of doing HPE of conjunctival scrapping before and 4 weeks after treatment with these two drugs.
Material and method:
A double blind randomised study conducted at a tertiary eye care centre in Hyderabad with a study period from July 2004 and July 2005 was done. 100 patients of vernal kerato conjunctivitis were randomly divided in 2 groups of 50 each. Group 1 was given FML eye drops 4 times daily for 4 weeks. Group 2 was given azelastine eye drops 4 times daily for 4 weeks. All patients with VKC were included in the study. Patients with other eye disorders, corneal involvement, glaucoma and patients who received treatment within 1 month were excluded. HPE of conjunctival scrappingâ€™s was done in both groups.
At the end of four weeks HPE was repeated 50 patients in group 1 showed absence of eosinophils and mast cells, whereas in group 2 only 15 cases showed absence of eosinophils and mast cells.
Observation:Statistic chi square test show P value of 0 in group 1 and 0.3 in group 2 which is significant and proves that FML is superior to azelastine in the treatment of VKC.
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