THE HEPATOPROTECTIVE AND ANTIFIBROTIC POTENTIAL OF ROOT EXTRACT OF ALOCASIA INDICA LINN. AGAINST CCL4 INDUCED HEPATIC INJURY AND FIBROSIS IN WISTAR RATS.
AbstractThe hepatoprotective activity of hydro-alcohol extract of roots of Alocasia indica Linn. (AI-E) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The AI-E at dose of 400 mg/kg is administered orally once daily for fourteen days. The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), glutamate pyruvate transaminase (ALT), alkaline phosphatase (ALP), total lipoprotein (TP), total cholesterol (TC), triglyceride (TG), albumin (ALB), hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD), hyaluronic acid (HA) Â and liver index were restored towards normalization significantly by the AI-E at dose of 400 mg/kg. AI-E 400mg/kg dose exhibited significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that roots of Alocasia indica have potent hepatoprotective activity against carbon tetrachloride induced hepatic damage in experimental animals. This study suggests that possible mechanism of this activity may be due to the presence of flavonoids and phenolics compound in the AI-E which may be responsible to hepatoprotective activity.
Download data is not yet available.
176 Views | 232 Downloads
How to Cite
Choudhury A. THE HEPATOPROTECTIVE AND ANTIFIBROTIC POTENTIAL OF ROOT EXTRACT OF ALOCASIA INDICA LINN. AGAINST CCL4 INDUCED HEPATIC INJURY AND FIBROSIS IN WISTAR RATS. JDDT [Internet]. 20Aug.2014 [cited 19May2022];4(4):145-9. Available from: http://jddtonline.info/index.php/jddt/article/view/934
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).